2022
DOI: 10.34172/hpp.2022.16
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Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies

Abstract: Background: Oxidative stress has a significant role in the commencement and development of hyperglycemia. Vanadium, as a transitional metal with redox properties, enters the redox process, produces free radicals, and distracts the pro-antioxidant balance. The present animal systematic review aimed to assess the effect of vanadium supplementation on inflammation and oxidative stress biomarkers in diabetes-induced animals. Methods: A systematic search was conducted using the PubMed, Scopus, and web of science da… Show more

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Cited by 6 publications
(3 citation statements)
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References 64 publications
(220 reference statements)
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“…Since the 1970s, several oxidovanadium complexes have been discussed as insulin-enhancer agents with beneficial effects on glucose and lipid metabolism, in vitro and in vivo [ 1 , 2 , 3 , 4 , 5 , 6 , 28 , 29 , 30 , 31 ]. Among the various animal models of diabetes, the most widely used for vanadium compounds is streptozotocin (STZ) induced [ 32 , 33 , 34 , 35 , 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…Since the 1970s, several oxidovanadium complexes have been discussed as insulin-enhancer agents with beneficial effects on glucose and lipid metabolism, in vitro and in vivo [ 1 , 2 , 3 , 4 , 5 , 6 , 28 , 29 , 30 , 31 ]. Among the various animal models of diabetes, the most widely used for vanadium compounds is streptozotocin (STZ) induced [ 32 , 33 , 34 , 35 , 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…In a different study, a 4-week V supplementation reduced malondialdehyde (MDA) and inhibited endoplasmic reticulum stress and inflammatory response in addition to controlling body weight gain in HFD mice (30). In the majority of diabetes-induced animal studies, V administration was able to regulate oxidative stress biomarkers by restoring enzyme production at normal levels, such as raising catalase or glutathione peroxidase (31).…”
Section: Discussionmentioning
confidence: 99%
“…The ability of vanadium compounds to impact oxidative stress and the formation of LPO products is well documented [ 237 ]. Since vanadium remains a comparatively underexplored metal [ 238 ], new compounds are being assayed to determine their potential for alleviating oxidative stress [ 239 , 240 ]. Novel compounds are being designed which affect LPO but lack cellular toxicity.…”
Section: Vanadium Effects On Lipid Peroxidation and Disease Processesmentioning
confidence: 99%