Smoking Impairs Endothelial Function in Human Saphenous Vein in an Ex Vivo Model

Sharif, Muhammad; Bayraktutan, Ulvi; Arya, Nityanand; O'Donnell, M.E.; Badger, Stephen A.; Soong, Chee V.

doi:10.1016/j.avsg.2008.04.006

Cited by 10 publications

(11 citation statements)

References 29 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One Swedish study including 292 patients with T1DM, aged 18-59 years, found that self-reported depression, obesity and smoking were independently associated with inadequate glycaemic control of diabetes [24]. Smoking may bring about endothelial dysfunction and vasoconstriction that affects the insulin absorption thus disturbs blood glucose [25][26][27]. Although diabetes guidelines advise all patients not to smoke [15], our study showed that 15.2% were current smokers.…”

Section: Discussionmentioning

confidence: 79%

Glycaemic control and its associated factors in Chinese adults with type 1 diabetes mellitus

Liu

Yang

Zhang

et al. 2015

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 79%

Glycaemic control and its associated factors in Chinese adults with type 1 diabetes mellitus

Liu

Yang

Zhang

et al. 2015

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

“…[6][7][8] Risk factors associated with early failure of venous bypasses are associated with a reduced endothelial function of saphenous vein grafts. 4,9,10 In addition, elevated pressures of distension of saphenous veins during venous graft preparation are associated with endothelial damage and endothelial dysfunction, which can favor the early failure of the graft. 7,35 Rac1 may be involved in all these conditions.…”

Section: Discussionmentioning

confidence: 99%

“…However, endothelial dysfunction also appears to contribute significantly to the development of vein‐related diseases . Venous endothelial function is significantly affected by cardiovascular risk factors such as diabetes mellitus and a smoking habit, which are known to impair arterial function and to promote cardiovascular diseases . Endothelial dysfunction appears to be involved in the development of deep vein thrombosis and vein insufficiency .…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7][8] Venous endothelial function is significantly affected by cardiovascular risk factors such as diabetes mellitus and a smoking habit, which are known to impair arterial function and to promote cardiovascular diseases. 4,[9][10][11] Endothelial dysfunction appears to be involved in the development of deep vein thrombosis 3 and vein insufficiency. 5 In addition, an impairment of endothelial function could be implicated in the development of venous graft remodeling, atherosclerosis, and failure in subjects undergoing myocardial surgical revascularization through bypass implantation.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction

Carrizzo

Vecchione

Damato

et al. 2017

JAHA

View full text Add to dashboard Cite

BackgroundEndothelial dysfunction contributes significantly to the development of vascular diseases. However, a therapy able to reduce this derangement still needs to be identified. We evaluated the effects of pharmacological inhibition of Rac1, a small GTPase protein promoting oxidative stress, in human endothelial dysfunction.Methods and ResultsWe performed vascular reactivity studies to test the effects of NSC23766, a Rac1 inhibitor, on endothelium‐dependent vasorelaxation of saphenous vein segments collected from 85 subjects who had undergone surgery for venous insufficiency and from 11 patients who had undergone peripheral vascular surgery. The endothelium‐dependent vasorelaxation of the varicose segments of saphenous veins collected from patients with venous insufficiency was markedly impaired and was also significantly lower than that observed in control nonvaricose vein tracts from the same veins. Rac1 activity, reactive oxygen species levels, and reduced nicotine adenine dinucleotide phosphate (NADPH) oxidase activity were significantly increased in varicose veins, and NSC23766 was able to significantly improve endothelium‐dependent vasorelaxation of dysfunctional saphenous vein portions in a nitric oxide–dependent manner. These effects were paralleled by a significant reduction of NADPH oxidase activity and activation of endothelial nitric oxide synthase. Finally, we further corroborated this data by demonstrating that Rac1 inhibition significantly improves venous endothelial function and reduces NADPH oxidase activity in saphenous vein grafts harvested from patients with vascular diseases undergoing peripheral bypass surgery.ConclusionsRac1 pharmacological inhibition rescues endothelial function and reduces oxidative stress in dysfunctional veins. Rac1 inhibition may represent a potential therapeutic intervention to reduce human endothelial dysfunction and subsequently vascular diseases in various clinical settings.

show abstract

“…The degree of FMD and PAT values reduction in response to ischemia was proportional to the number of risk factors present in the studied groups of patients and predicted the occurrence of cardiovascular incidents [6,14,15,17,33] including even venous thrombosis [34]. Smoking cessation [33,[35][36][37], hypertension [32,37,38], treatment of hyperlipidemia [39][40][41][42], diabetes control [43], body mass reduction [44], improvement of physical activity [31,45,46] as well as peripheral revascularization involving lower extremities [16,[21][22][23]26] and renal arteries [24,25] were shown to improve the markers of endothelial function not only in the culprit lesion, but also in other vascular beds. In this context it is logical to hypothesize that control of individual risk factors of atherosclerosis may modify the course of changes of global endothelial function after percutaneous revascularization of the lower extremities.…”

Section: Introductionmentioning

confidence: 99%

The effect of superficial femoral artery stenting and some atherosclerosis risk factors on changes in selected global endothelial function tests in patients with chronic lower limb ischemia. A pilot study

Budzyński¹,

Wı́sniewska²,

Wasielewski³

et al. 2012

pwki

View full text Add to dashboard Cite

A b s t r a c tIntroduction: Endothelial dysfunction is the main pathomechanism of atherosclerotic processes and their complications. Revascularization and control of atherosclerosis risk factors may improve the global endothelial function.Aim: Assessment of the relationships between the level of selected atherosclerosis risk factors and changes in noninvasive endothelial function parameters during one year long follow-up after superficial femoral artery (SFA) stenting.Material and methods: Seventeen male patients after SFA stenting were studied. Before the endovascular procedure, one day after it, and after 1, 3, 6, and 12 months after SFA stenting the values of global endothelial function parameters were evaluated, as follows: ankle-brachial index (ABI), flow-mediated brachial artery dilatation, distensibility coefficient, and Doppler parameters of blood flow in brachial and common carotid arteries in response to brachial ischemia and nitroglycerin sublingual application as well as intima-media complex thickness.Results: Of the studied parameters only ABI improved significantly after SFA stenting. The changes in values of investigated endothelial function parameters were related to presence of atherosclerotic risk factors, such as age above 62 years, hypercholesterolemia, diabetes, and hypertension. Generally, global endothelial function tests were worse in patients with these conditions before the endovascular procedure, then they improved to reach the level observed in individuals without cardiovascular risk factors already after 3 to 6 months after SFA stenting.Conclusions: The SFA stenting together with adequate pharmacotherapy may reduce the negative effect of comorbidities on the global endothelial function and vasodilatation reserve of brachial and carotid arteries.Key words: endothelium, atherosclerosis, superficial femoral artery stenting S t r e s z c z e n i e Wstęp: Zaburzenie funkcji śródbłonka jest podstawowym mechanizmem patogenetycznym rozwoju i powikłań miażdżycy naczyń. Wiadomo, że zabieg rewaskularyzacyjny i kontrola czynników ryzyka rozwoju miażdżycy mogą poprawiać globalną funkcję śródbłonka.Cel: Ocena związku wybranych czynników ryzyka wystąpienia miażdżycy ze zmianami wartości nieinwazyjnych wskaźników funkcji śródbłonka w ciągu rocznej obserwacji pacjentów po stentowaniu tętnicy udowej powierzchownej (TUP).Materiał i metody: Analizie poddano wartości wskaźników zaburzenia funkcji śródbłonka u 17 mężczyzn leczonych metodą stentowania TUP z powodu chromania przestankowego. Przed zabiegiem, w dobę po stentowaniu TUP, oraz po 1, 3, 6 i 12 miesiącach od wykonania procedury wewnątrznaczyniowej zbadano: wskaźnik kostka-ramię (WKR), dylatację tętnicy ramiennej oraz wskaźnik rozszerzalności tętnicy ramiennej i szyjnej w odpowiedzi na niedokrwienie i podanie nitrogliceryny, a także parametry dopplerowskie przepływu w tętnicy ramiennej i grubość kompleksu intima-media tętnicy szyjnej wspólnej.

show abstract

Smoking Impairs Endothelial Function in Human Saphenous Vein in an Ex Vivo Model

Cited by 10 publications

References 29 publications

Glycaemic control and its associated factors in Chinese adults with type 1 diabetes mellitus

Glycaemic control and its associated factors in Chinese adults with type 1 diabetes mellitus

Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction

The effect of superficial femoral artery stenting and some atherosclerosis risk factors on changes in selected global endothelial function tests in patients with chronic lower limb ischemia. A pilot study

Contact Info

Product

Resources

About