Glycaemic control and its associated factors in Chinese adults with type 1 diabetes mellitus

Liu, Li; Yang, Daizhi; Zhang, Yan; Lin, Shuo; Zheng, Xueying; Lin, Shaoda; Chen, Li-Shu; Zhang, Xiuwei; Li, Lü; Liang, Ganxiong; Yao, Bin; Yan, Jinhua; Weng, Jianping

doi:10.1002/dmrr.2716

Cited by 25 publications

(30 citation statements)

References 37 publications

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“…Other studies vary in the numerical value of the HbA1c that they use to determine good control. However comparisons are able to be made between the average HbA1c of the participants in the present study (8.4%; 68 mmol mol −1 ) and the average disease duration of 16.8 years with other studies in Australia, China and USA, where HbA1c ranged from 8.4% to 8.6% (68–70 mmol mol −1 ) and disease duration was comparable . This emphasises that the difficulty in achieving good glycaemic control was not unique to the participants in the present study.…”

Section: Discussionsupporting

confidence: 53%

“…The present study was also limited in that it did not measure factors that were investigated in other studies, such as total daily insulin dose, the presence of diabetic autoantibodies and low fasting C‐peptide . Childhood environment, socio‐economic status and engagement in work or study were also not investigated.…”

Section: Discussionmentioning

confidence: 96%

“…An awareness of the factors that influence glycaemic control is important for clinicians who are providing care for individuals with type 1 diabetes. Previous studies have identified factors that are associated with good glycaemic control, such as an increased frequency of blood glucose monitoring , consistency in taking insulin , an increased frequency of diabetes visits and a reduced presence of diabetes autoantibodies . A shorter duration of diabetes, being male and engagement in work or study have also been identified as having an association with good glycaemic control .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Carbohydrate knowledge, lifestyle and insulin: an observational study of their association with glycaemic control in adults with type 1 diabetes

Smythe

Saw

Mak

et al. 2018

J Human Nutrition Diet

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Carbohydrate knowledge, lifestyle and insulin: an observational study of their association with glycaemic control in adults with type 1 diabetes

Smythe

Saw

Mak

et al. 2018

J Human Nutrition Diet

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show abstract

“…A study from Brazil investigating poor metabolic control and endothelial dysfunction in patients with T1DM determined a positive relationship between age, smoking and dyslipidemia and hypertension [44]. Smoking and dyslipidemia are major risk factors for chronic complications of T1DM [44][45][46][47][48][49]. Another study emphasizes that smoking is one of the most influential factors for atherosclerosis [50].…”

Section: Discussionmentioning

confidence: 99%

The prevalence of dyslipidemia and associated factors in children and adolescents with type 1 diabetes

Bulut

Demirel

Metìn

2017

Journal of Pediatric Endocrinology and Metabolism

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Background: Dyslipidemia increases the frequency and severity of micro and macrovascular complications of type 1 diabetes (T1D). The present study aims to determine the prevalence of dyslipidemia and its association with clinical and laboratory findings in diabetic children and adolescents. Methods: The study included 202 children and adolescents with T1D. Demographic data and laboratory findings were obtained from patients files. Results: Dyslipidemia prevalence was found to be 26.2%. Hypercholesterolemia (15.8%) and hyperglyceridemia (12.9%) were most common findings. Age, body mass index (BMI), hemoglobin A 1c (A 1C ) and poor metabolic control were significantly higher in cases with dyslipidemia. Smoking rate was 14.1% in the pubertal group. Poor metabolic control and dyslipidemia was found higher among smokers (p < 0.05).Conclusions: Blood lipid levels should be monitored regularly and nutrition education should be repeated periodically to prevent and control dyslipidemia in patients with T1D. Smoking-related risks should be a part of patient education in the pubertal period.

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“…Serum levels of autoantibodies against GAD 65, IA‐2, and ZnT8 were detected by radioimmunoassay confirmed by the Islet autoantibody Standardization Program as previously described . The cut‐off for positivity for GADA, IA2A, and ZnT8A was defined as a value above 0.05, 0.02, and 0.011, respectively.…”

Section: Methodsmentioning

confidence: 99%

A pilot study of preproinsulin peptides reactivity in Chinese patients with type 1 diabetes

Xian

Gao

et al. 2019

Diabetes Metabolism Res

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Background:The aim of our study is to investigate whether preproinsulin (PPI) could trigger a proinflammatory CD4 + T cell response in Chinese patients with type 1 diabetes (T1D). Methods:Peripheral blood mononuclear cells were stimulated by a pool of 13 PPI peptides. Additional five PPI peptides previously proved to be antigenic in other cohorts of patients with T1D were also used. PPI reactive T cell responses were measured by interferon (IFN)-γ ELISPOT assay.Results: Fifty-one Chinese patients with T1D were enrolled in this study and 72.34% of them were positive for at least one islet autoantibody. The stimulation index (SI) value of IFN-γ response to PPI peptide pool or peptides with dominant epitopes was below 3 in patients when SI≥3 was used as the positive cut-off value. Two peptides (B9-23 and C19-A3) restricted to DQ8 or DR4 molecule failed to induce positive IFN-γ response in patients with high-risk HLA-DQ8 or HLA-DR4/DR9 alleles. RNA-seq analysis of PPI specific CD4 + T cell lines further showed that most of the IFN-γ associated genes remained unchanged.Conclusions: This is the first report of CD4 + T cell epitope mapping of PPI in Chinese T1D. The lack of positive IFN-γ response to PPI peptides indicates that PPI might not be the principal antigenic candidate for autoreactive CD4 + T cells in Chinese T1D. Therefore, the efficacy of PPI-based immunotherapies in attenuating proinflammatory CD4 + T cell response requires further investigation.

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Glycaemic control and its associated factors in Chinese adults with type 1 diabetes mellitus

Abstract: Most adult patients with T1DM did not achieve the HbA1c target. Identifying determinants for glycaemic control provides us valuable information to improve glycaemic control in these patients. Copyright © 2015 John Wiley & Sons, Ltd.

Cited by 25 publications

References 37 publications

Carbohydrate knowledge, lifestyle and insulin: an observational study of their association with glycaemic control in adults with type 1 diabetes

Carbohydrate knowledge, lifestyle and insulin: an observational study of their association with glycaemic control in adults with type 1 diabetes

The prevalence of dyslipidemia and associated factors in children and adolescents with type 1 diabetes

A pilot study of preproinsulin peptides reactivity in Chinese patients with type 1 diabetes

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