Smad7 in psoriasis vulgaris patients: A clinical and immunohistochemical study

Abstract

Background Psoriasis is an inflammatory disease that is mostly immune‐derived. It causes proliferation of skin cells, forming plaques. Psoriasis etiology is unknown. It might be multifactorial. Aims This work aimed to study Smad7 expression in psoriasis vulgaris patients in comparison with normal skin. Patients/Methods Thirty patients with psoriasis vulgaris in comparison with 20 age‐ and sex‐matched seemingly healthy individuals were selected. We used psoriasis area and severity index (PASI) to evaluate psoriasis severity. Skin biopsies were prepared from skin lesions (30), perilesions (30) and control (20) groups for histopathological and immunostaining evaluation of Smad7. Results Smad7 was progressively upregulated in proliferating keratinocytes from controls (58.18 ± 30.93) to perilesional (106 ± 38.93) and lesional (156.33 ± 62.01) skin (P < .001). Also, dermal inflammatory cells showed upregulation of Smad7 expression from control skin (40 ± 28.28) to skin lesions (137.33 ± 73.86) (P < .010). Smad7 expression showed a positive significant correlation with psoriasis severity (r = .452; P < .012). Conclusion Smad7 may be involved in increased keratinocyte proliferation as well as skin inflammation in psoriasis vulgaris patients.

Role of CYR61 in psoriatic lesional and perilesional skin: A clinical and immunohistochemical study

“…In the studied cases, perilesional psoriatic skin exhibited significantly higher mean values of H‐score of CYR61 than those of control skin. Our results were in line with other studies which stated that psoriatic perilesional skin is likely to develop psoriasis 11,23 . This suggests that CYR61 may have a role in triggering Koebner's phenomenon which is critical in inducing secondary psoriatic lesions in healthy areas after injury leading to more spread and relapse of psoriasis 23 …”

“…PASI score ranged from 0 to 72: less than 7, mild disease; 7‐12, moderate psoriasis; more than 12, severe psoriasis 3,11 …”

“…Then, the staining intensity was categorized as mild, moderate, or strong. H‐score (histo‐score) was estimated using the following formula: H score = 1 × percent of mildly stained cells + 2 × percent moderately stained cells + 3 × percent of strongly stained cells 11,15 . Besides, the expressions of CYR61 in dermal inflammatory cells and vascular endothelial cells were similarly assessed, and H‐scores were estimated.…”

Stigmatization in Patients With Psoriasis: A Mini Review

“…Psoriasis is a chronic and recurrent inflammatory skin disease characterized by clearly demarcated, scaly, erythematous plaques (1)(2)(3)(4). Beyond the conventional definition of a skin disorder, psoriasis is now considered a systemic disease (5).…”

Circulating long noncoding RNA growth arrest‐specific transcript 5 as a diagnostic marker and indicator of degree of severity in plaque psoriasis

“…The full history of the subjects was taken, and they were subjected to clinical examination. Assessment of psoriasis severity was done using the PASI score, and a PASI score below 7 was defined as mild, between 7 and 12 as moderate, and above 12 as severe 12 …”