Role of CYR61 in psoriatic lesional and perilesional skin: A clinical and immunohistochemical study

Abstract

Background Psoriasis is considered as an immune‐mediated disorder with significant epidermal hyperplasia and inflammation. Cysteine‐rich angiogenic inducer 61 (CYR61), known as CCN family member 1 (CCN1), plays an important role in cell proliferation and neovascularization which may trigger psoriasis development. Aims This study aimed to assess the immunostaining of CYR61 in psoriatic skin (lesional and perilesional) compared to control skin. Patients/Methods This is a case‐control study. The Psoriasis Area and Severity Index (PASI) was used to evaluate disease severity. A punch biopsy was taken from psoriatic skin lesions (30), perilesional (30) skin, and matched site of controls (20). The pathological and immunostaining assessments of CYR61 were conducted. Results There was a significant gradual progressive overexpression of CYR61 in keratinocytes from control skin to perilesional and lesional psoriatic skin (P = .00). Moreover, lesional psoriatic skin showed overexpression of CYR61 in inflammatory cells in the dermis than controls. CYR61 expression (lesional epidermis) revealed a significant positive correlation with the PASI score (r = .63; P = .00). There was a significant relationship between intensity and H‐core of CYR61 in the lesional psoriatic epidermis with joint affection. Conclusion CYR61 may trigger epidermal hyperplasia and potentiate inflammatory infiltration in psoriasis vulgaris patients, and therapies targeting CYR61 may be effective in the management of psoriasis vulgaris.

CD93 has a crucial role in pathogenesis of psoriasis

“…A detailed history was taken from every patient, complete general examination, thorough dermatological examination with determination for the site of the lesion, the course of psoriasis was evaluated as stationary or progressive during history taking, and the onset of psoriasis was either early onset which arises at or before the age of 40 years old and late‐onset psoriasis which occurs after the age of 40 years old 14 …”

“…Then, the sum of the severity scores for the clinical signs for each skin region was determined and then multiplied by the score for that affected area and by the weight of this portion. (0.1 for the head; 0.2 for upper extremities; 0.3 for the trunk; 0.4 for lower extremities) 14 …”

“…(0.1 for the head; 0.2 for upper extremities; 0.3 for the trunk; 0.4 for lower extremities). 14 As a final point, evaluation of PASI score was done using the following calculation step: PASI score = 0.…”

Uncoupling protein 2 and dynamin‐related protein 1 mRNA expressions as genetic markers for plaque psoriasis

“…Data were taken from every case followed by full general and detailed dermatological examinations. Assessment of the course of psoriasis was assessed either early stationary or progressive, while the course of psoriasis was either early (before the age of 40 years old) or late (after the age of 40 years old) 4 …”

“…Psorasis area and severity index (PASI) score was used to assess the severity of psoriasis in the studied cases. The severity of the disease was evaluated as follows: PASI ranged from 0 to 72: less than 7 indicates mild psoriasis; 7–12 means moderate psoriasis; more than 12 is severe psoriasis 4 …”