SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 70% BIJI KALANGKALA (Litsea angulata Bl.) TERHADAP BAKTERI PENYEBAB JERAWATPropionibacterium acnes

Ramadhan, Hafiz; Arsyad, Muhammad; Sayakti, Putri Indah

doi:10.51817/bjp.v4i1.283

Cited by 5 publications

(8 citation statements)

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“…Extraction is the first step in purification and isolation of bioactive compounds in plant material (Ćujić et al 2016) Extraction of red ginger and secang wood using maceration method with ethanol 96%. The advantages of maceration method is easy and does not require high temperatures which are likely to damage chemical compounds that have several bioactivities (Ramadhan et al 2020). Ethanol is a solvent that is effective for extracting secondary metabolites and has good penetration ability on the hydrophilic and lipophilic site so that it penetrates the cell membranes and enters the cell to interact with secondary metabolites (Andriani & Murtiswi 2018).…”

Section: Results and Discussion Extraction Of Red Ginger And Secang Woodmentioning

confidence: 99%

Phytochemical Screening and Total Phenolic Compounds of Red Ginger (Zingiber officinale) and Secang Wood (Caesalpinia sappan) As Preliminary Test of Antiarthritis

2021

cna

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Rheumatoid arthritis is an auto-immune disease that causes chronic inflammation occurs of the joints. Rheumatoid arthritis is characterized by the the overproduction of proinflammation cytokines such as TNF-α and IL-1. The phenolic compounds mainly anthocyanin and elagitanin have TNF-α inhibition activity that induces cyclooxygenase-2 expressions that cause inflammation. Phytochemical screening showed that ethanol extract of red ginger contains alkaloids, phenolics, flavonoids, tannins, terpenoid, and steroids while ethanol extract of secang wood contains alkaloids, phenolics, flavonoids, tannins, and terpenoid. This research aims to identify the secondary metabolite qualitatively and total phenolic compunds on red ginger and secang wood with Folin-Ciocalteu method. Total phenolic compounds are defined as the Gallic Acid Equivalent (GAE). The results showed that the total phenolic compunds of red ginger and sappan wood were 21.90 mg GAE/g extract and 27.65 mg GAE/g extract, respectively. The phenolic compounds in red ginger and secang wood have the potential as antiarthritic.

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Section: Results and Discussion Extraction Of Red Ginger And Secang Woodmentioning

confidence: 99%

Phytochemical Screening and Total Phenolic Compounds of Red Ginger (Zingiber officinale) and Secang Wood (Caesalpinia sappan) As Preliminary Test of Antiarthritis

2021

cna

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“…pereaksi Mayer terbentuk endapan kuning, dan penambahan pereaksi Wagner terbentuk endapan coklat kemerahan (15) .…”

Section: Pendahuluanunclassified

“…Uji Tanin. Sampel sebanyak 1 mL ditambahkan gelatin 1% yang mengandung NaCl, jika terbentuk sedimen putih, maka menunjukkan kandungan tanin (15) .…”

Section: Pendahuluanunclassified

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Uji Aktivitas Antioksidan Fraksi N-Heksan dari Ekstrak Metanol Daun Binjai Mangifera caesia Jack. Ex. Wall Menggunakan Metode DPPH

Ramadhan¹,

Purnama²,

Sayakti³

2022

jifi

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Senyawa antioksidan alami dapat ditemukan pada tumbuhan dari genus Mangifera, salah satunya yaitu Mangifera caesia Jack. ex. Wall atau yang lebih dikenal dengan binjai. Penelitian ini bertujuan untuk mengetahui golongan senyawa dan aktivitas antioksidan fraksi n-heksan dari ekstrak metanol daun binjai terhadap radikal 2,2-diphenyl-1-picrylhydrazyl (DPPH). Ekstraksi serbuk daun binjai dilakukan menggunakan alat soxlet dengan metanol dan difraksinasi cair-cair menggunakan air dan n-heksan. Skrining fitokimia dilakukan dengan penambahan pereaksi spesifik. Uji aktivitas antioksidan secara kualitatif pada plat KLT yang disemprot dengan DPPH dan pengujian secara kuantitatif dengan mengukur absorbansi peredaman fraksi terhadap radikal DPPH menggunakan Spektrofotometer UV-Vis. Hasil skrining fitokimia menunjukkan bahwa fraksi n-heksan mengandung fenolik, flavonoid dan steroid. Hasil uji kualitatif menunjukkan terdapat senyawa yang memiliki aktivitas antioksidan dengan berubahnya warna bercak noda menjadi kuning dengan latar ungu pada plat KLT setelah disemprot dengan larutan DPPH. Fraksi n-heksan memiliki nilai IC50 sebesar 34,0668 ppm dengan IC50 kuersetin sebesar 2,4469 ppm. Berdasarkan hasil tersebut, dapat disimpulkan bahwa fraksi n-heksan dari ekstrak metanol daun binjai mengandung senyawa golongan fenolik dan flavonoid yang berperan dalam menghasilkan aktivitas antioksidan yang sangat kuat.

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“…The antibacterial activity of plant extracts and liquid crystal nanoparticles based gel of Binjai was evaluated by cup plate technique. Propionibacterium acnes suspension that was made according to Ramadhan et al [20] was inoculated and spread exactly 100 µl on six plates of Mueller Hinton Agar (MHA) media which were Binjai leaves methanol extract, LCNPs of extract, gel of extract, gel of extract LCNPs, negative control used gel base, and positive control using clindamycin. Each plate is given one hole, which will be filled with samples test, positive control, and control negative.…”

Section: Antibacterial Activity Assaymentioning

confidence: 99%

Antibacterial Activity of Liquid Crystal Nanoparticles Gel of Binjai Leaves Methanol Extract (Mangifera Caesia Jack. Ex. Wall.) Against Propionibacterium Acnes

et al. 2022

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Objective: This study aims to compare the anti-Propionibacterium acnes activity between the optimum formula of gel liquid crystal nanoparticles of Binjai leaves methanol extract and the gel of extract without the liquid crystal nanoparticles system. Methods: Preparation of liquid crystal nanoparticles using top-down methods with 6% Capmul-GMO 90 and 5% Plantacare 818. Preparation of the optimum gel formula using 7% Viscolam Mac 10 as a gelling agent. The antibacterial activity was evaluated by cup plate technique and clindamycin was used as a positive control. Results: The results obtained are liquid crystal nanoparticles based gel of methanol extract of Binjai leaves produces a strong category as anti-Propionibacterium acnes with an average inhibition of 15.33±1.2413 mm and the gel of extract without the liquid crystal nanoparticles system only produces 13.53±1.241 mm. Conclusion: The gel of Binjai leaves extract with a liquid crystal nanoparticles system has a higher antibacterial effect on Propionibacterium acnes than the gel of extract without the liquid crystal nanoparticles system.

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SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 70% BIJI KALANGKALA (Litsea angulata Bl.) TERHADAP BAKTERI PENYEBAB JERAWATPropionibacterium acnes

Cited by 5 publications

References 0 publications

Phytochemical Screening and Total Phenolic Compounds of Red Ginger (Zingiber officinale) and Secang Wood (Caesalpinia sappan) As Preliminary Test of Antiarthritis

Phytochemical Screening and Total Phenolic Compounds of Red Ginger (Zingiber officinale) and Secang Wood (Caesalpinia sappan) As Preliminary Test of Antiarthritis

Uji Aktivitas Antioksidan Fraksi N-Heksan dari Ekstrak Metanol Daun Binjai Mangifera caesia Jack. Ex. Wall Menggunakan Metode DPPH

Antibacterial Activity of Liquid Crystal Nanoparticles Gel of Binjai Leaves Methanol Extract (Mangifera Caesia Jack. Ex. Wall.) Against Propionibacterium Acnes

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