Skin tags, leptin, metabolic syndrome and change of the life style

Safoury, Omar Soliman El; Hay, Rania Abdel; Fawzy, Marwa M.; Kadry, Dina; Amin, Iman M.; Zeid, Ola M. Abu; Rashed, Laila Ahmed

doi:10.4103/0378-6323.84061

Cited by 15 publications

(15 citation statements)

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“…This is an agreement with El Safoury et al ., (2011) who measured the association of the METs in patients with STs and found a significant association, 26/40 (65%) compared to the control group 2/40 (5%) ( P < 0.001)[23] and in agreement with Shaheen et al ., (2011) who found that 71% of patient with STs fulfilled the criteria of METs. [24]…”

Section: Discussionsupporting

confidence: 80%

“…A higher statistical significant difference in BMI was found in the cardiac-STs and non-cardiac-STs groups than in the control group ( P < 0.001). This is an agreement with Sari et al ., (2010)[21] who found that mean BMI was (29.9 ± 5.3) in the STs group and (21.5 ± 3.5) in the control group ( P < 0.001), with El Safoury et al .,[23] who found that BMI mean was 35.2 ± 7.05 in the STs group and 28.03 ± 4.29 in the control group ( P < 0.001), with Shaheen et al .,[24] who found that the number and extent of STs increased with the increase in obesity, with the results of Puneet and Deepak.,[27] who reported an association between STs, impaired glucose tolerance, and obesity, and finally with the results of Garcia-Hidalgo et al .,[28] who studied 156 obese patients and found that percentage of those with STs increased with severity of obesity.…”

Section: Discussionmentioning

confidence: 99%

“…(2011). [23] Although HDL level was low in the cardiac-STs group, moderate in the non-cardiac-ST group and high in the control, yet HDL level was statistically different only in the cardiac group-STs relative to controls. This is in agreement with Sari et al ., (2010)[21] who found a significant difference in HDL level between STs cases, 50.0 mg/dl ± 12.3 and control, 61.8 mg/dl ± 14.5.…”

Section: Discussionmentioning

confidence: 99%

“…[2] The association between STs and metabolic syndrome (METs) has been investigated. [3] However, the literature is short of comprehensive and controlled clinical studies evaluating the atherogenic risk factors in patients with STs. [4]…”

Section: Introductionmentioning

confidence: 99%

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The evaluation of the impact of age, skin tags, metabolic syndrome, body mass index, and smoking on homocysteine, endothelin-1, high-sensitive C-reactive protein, and on the heart

et al. 2013

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Background:Skin tags (STs) are small, pedunculated skin-colored or brown papules that occur around any site where skin folds occur. The literature is short of comprehensive and controlled clinical studies aimed to evaluate the atherogenic risk factors in patients with STs.Aim of Work:The aim of this study is to evaluate the impact of age, STs, metabolic syndrome (METs), body mass index (BMI), and smoking on homocysteine (Hcy), endothelin-1 (ET-1), high-sensitive C-reactive protein (Hs-CRP), and on cardiovascular diseases.Materials and Methods:This study included 30 cardiac patients with STs, 30 non-cardiac patients with STs, and 30 healthy controls with neither heart disease nor STs. History of smoking, measurement of height, weight, BMI, waist circumference (WC), blood pressure, STs number, color, acanthosis nigricans, estimation of serum level of fasting glucose, triglycerides (TGs), cholesterol, high-dense lipoproteins (HDL), Hcy, ET-1, Hs-CRP, and the presence of the METs were elicited in the three groups.Results:Regarding the Hcy, ET-1, and Hs-CRP, the cardiac-STs group showed the highest levels and the control group showed the least (P < 0.001). The percents of patients with METs were 56.7% in the cardiac-STs, 40% in the non-cardiac-STs, and 0% in the control group (P < 0.001). Mean BMI exceeded the limit of obesity in the cardiac-STs group (30.9 ± 3.9) and the non-cardiac-STs group (32.6 ± 6) and was normal in the control group (24.7 ± 2.8). Hyperpigmented STs were present in 66.7% of the cardiac-STs group. Multivariate regression analysis for the independent effectors on Hcy level were the presence of STs (P < 0.001), METs (P = 0.001), and BMI (P = 0.024). Regarding ET-1, the effectors were the presence of STs and METs (P = 0.032). For Hs-CRP, effectors were the presence of STs (P < 0.001) and smoking (P = 0.040). Multivariate logistic regression of the predictors of cardiac disease showed that the independent predictors of the occurrence of cardiac disease were BMI (P < 0.001), STs (P = 0.002), and METs (P = 0.037).Conclusion:STs may act as a physical sign of underlying raised cardiac atherogenic factors. This may indicates an ongoing risk on coronary circulation which may indicate further corrective action, hopefully early enough. The association of ST with obesity and METs represents a Bermuda Triangle that act against the heart.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The evaluation of the impact of age, skin tags, metabolic syndrome, body mass index, and smoking on homocysteine, endothelin-1, high-sensitive C-reactive protein, and on the heart

et al. 2013

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“…Additional evidence was provided by El Safoury et al, [29], who showed that the presence of both ST and hyperleptinemia may be associated with high levels of triglycerides and low levels of HDL-C.…”

Section: Discussionmentioning

confidence: 88%

Leptin and c-reactive protein are implicated in the pathogenesis of skin tags

Hegazy¹,

El-Ashmawy²

2013

J Diab Res Clin Met

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Background: Skin tags (ST) are the most common benign skin lesions. In obesity, production of inflammatory cytokines by visceral adipose tissue (VAT) macrophages increases significantly. This situation creates a general subclinical inflammatory state that will ultimately lead to altered insulin responsiveness. The aim of the study is to investigate the possible involvement of leptin and some inflammatory markers in the development of skin tags. Patients and Methods: Twenty obese patients seeking advice for their STs, and 10 healthy volunteers serving as controls. Venous blood samples were collected after overnight fast. Laboratory measurements included determination of fasting blood glucose (FBG), glycated hemoglobin, insulin, leptin, high sensitive c-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), cholesterol, and triglycerides (TG). Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. Results: ST patients were insulin-resistant with elevated HOMA-IR. They showed higher levels of plasma cholesterol, triglycerides, LDL-cholesterol, hs-CRP and TNF-α than the control group. There was a positive correlation between leptin level and each of plasma TG, cholesterol, and insulin. Moreover, there was a positive correlation between the number of ST and each of hs-CRP, TNF-α, leptin and HOMA-IR. Conclusion:The subclinical higher levels of leptin, hs-CRP and TNF-α in ST patients may be implicated in the development of skin tags. Association between skin tags and insulin resistance is already known, however this article showed that leptin, hs-CRP and TNF-α in ST patients may be implicated in the development of skin tags.

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