Leptin in skin disease modulation

X, Su; Zhang, Guoming; Cheng, Yufeng; Wang, Bin

doi:10.1016/j.cca.2021.01.013

Cited by 10 publications

(9 citation statements)

References 81 publications

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“…Leptin increases the synthesis of pro-inflammatory mediators that play an important role in the development of psoriasis, such as TNF-α and CXCL8 [ 17 , 18 ]. These mediators can induce the activation of immune cells involved in the development of inflammation in the skin and psoriatic lesions [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Adiponectin, Leptin and Resistin in Patients with Psoriasis

Słuczanowska-Głąbowska

Staniszewska

Marchlewicz

et al. 2023

JCM

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Psoriasis is a common chronic, inflammatory skin disease characterised by keratinocyte hyperproliferation, parakeratosis, and T-cell infiltration. Adipose tissue has an endocrine function, producing an abundance of cytokines and adipokines. It has also been described that the major adipokines, leptin, resistin, and adiponectin, may be involved in the pathogenesis of psoriasis. The aim of the study was to examine the plasma levels of adiponectin, leptin, and resistin in patients with psoriasis and their correlations with disease activity parameters: Psoriasis Activity Severity Index (PASI), Dermatology Life Quality Index (DLQI), and Body Surface Area (BSA) index, as well as selected clinical parameters. The study included 53 patients with the plaque type and 31 healthy controls. The plasma concentrations of adiponectin were significantly lower in patients with psoriasis (p < 0.001) than in the control group. The plasma concentrations of leptin were higher in patients with psoriasis, however, due to high intra-patient variability of leptin plasma concentrations these differences did not reach statistical significance (p = 0.2). The plasma concentrations of resistin were significantly increased in patients with psoriasis compared to healthy controls (p = 0.02). There were no statistically significant correlations between adiponectin and leptin plasma concentrations and values of PASI, DLQI, and BSA. The resistin plasma concentrations correlated significantly with DLQI values. Additionally, we examined the correlations between adiponectin, leptin, and resistin plasma concentrations, and selected clinical parameters. Plasma concentrations of adiponectin correlated significantly with CRP values and ALT values. Leptin plasma concentrations correlated significantly with creatinine values. The results of our study confirm the role of adiponectin, leptin, and resistin in the pathogenesis of psoriasis.

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Section: Discussionmentioning

confidence: 99%

Adiponectin, Leptin and Resistin in Patients with Psoriasis

Słuczanowska-Głąbowska

Staniszewska

Marchlewicz

et al. 2023

JCM

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“…Stimulating them, leptin can activate JAK2 kinase which induces the tyrosine phosphorylation of the STAT3, SHP2, and PI3K proteins. Activated and dimerized STAT3 migrates to the nucleus, where it causes the expression of genes such as the suppressor of cytokine signaling 3 (SOCS3) [ 144 , 145 ]. All these pathways lead to mitochondrial metabolic activation and the efficiency of energy utilization.…”

Section: Leptinmentioning

confidence: 99%

The Role of Adipokines in the Pathogenesis of Psoriasis

Kiełbowski

Bakinowska

Ostrowski

et al. 2023

IJMS

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Psoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL-17 pathway enhances the disease progression. Human adipose tissue is an endocrine organ, which secretes multiple proteins, known as adipokines, such as adiponectin, leptin, visfatin, or resistin. Current evidence highlights the immunomodulatory roles of adipokines, which may contribute to the progression or suppression of psoriasis. A better understanding of the complexity of psoriasis pathophysiology linked with adipokines could result in developing novel diagnostic or therapeutic strategies. This review aims to present the pathogenesis of psoriasis and the roles of adipokines in this process.

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“…The current treatment of psoriasis in patients with obesity is directed towards a multidisciplinary approach [ 149 , 150 ] that contemplates a lifestyle change [ 151 , 152 ] through progressive weight loss, the combination of a diet rich in soluble fibre and physical exercise [ 153 ]. These changes modify the behaviour of adipocytokines that act on the immune-inflammatory state of psoriasis in patients with obesity [ 152 ], minimising the expression of the clinical manifestations of psoriasis that cause physical and psychological damage in this disease [ 150 ].…”

Section: The Link Between Psoriasis and Obesitymentioning

confidence: 99%

Exploring the Links between Obesity and Psoriasis: A Comprehensive Review

Barros

Durán

Vera

et al. 2022

IJMS

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Obesity is a major public health issue worldwide since it is associated with the development of chronic comorbidities such as type 2 diabetes, dyslipidemias, atherosclerosis, some cancer forms and skin diseases, including psoriasis. Scientific evidence has indicated that the possible link between obesity and psoriasis may be multifactorial, highlighting dietary habits, lifestyle, certain genetic factors and the microbiome as leading factors in the progress of both pathologies because they are associated with a chronic pro-inflammatory state. Thus, inflammation management in obesity is a plausible target for psoriasis, not only because of the sick adipose tissue secretome profile but also due to the relationship of obesity with the rest of the immune derangements associated with psoriasis initiation and maintenance. Hence, this review will provide a general and molecular overview of the relationship between both pathologies and present recent therapeutic advances in treating this problem.

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Leptin in skin disease modulation

Cited by 10 publications

References 81 publications

Adiponectin, Leptin and Resistin in Patients with Psoriasis

Adiponectin, Leptin and Resistin in Patients with Psoriasis

The Role of Adipokines in the Pathogenesis of Psoriasis

Exploring the Links between Obesity and Psoriasis: A Comprehensive Review

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