Skin prick test reactivity in atopic children and their number of siblings

Siregar, Beatrix; Irsa, Lily; Supriatmo, Supriatmo; Loebis, Sjabaroeddin; Evalina, Rita

doi:10.14238/pi55.4.2015.189-93

Cited by 2 publications

(1 citation statement)

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“…), ash tree (0.9%), fungi (0.9%), latex (0.7%) [12] . A cross sectional study by Beatrix Siregar et al, on 192 subjects found skin prick test positive for pet ownership (52.6%), history excessive breast feeding (32.3%) and cigarette smoke exposure (37.5%) [13] . A study by P Cullinan et al, included 552 children and followed from birth to 5.5 years of age found positive skin prick test for dust mites (9.6%), cat fur (8.5%), grass pollens (8.9%) and other allergens (16.7%) [14] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of skin prick test reactivity in children with allergic diseases: A cross sectional study

Kumar¹,

Srikrishna²,

Pavan³

et al. 2021

Int. J. Paediatrics Geriatrics

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Allergic diseases are developed through complex interaction between exposure to environmental substances and genetic susceptibility. The prevalence of allergic diseases has increased during last decade globally. The present cross sectional study was designed to evaluate the skin prick test reactivity in children with allergic diseases. A total of 400 children between age group 1-12 years were recruited. The Skin prick tests (SPT) using 14 standardized allergen extracts were conducted in the volar surface of forearm. Majority children had asthma (52.5%), followed by atopic dermatitis (22.75%) and allergic rhinitis (15.75%). Food habits triggering allergic conditions in 76% children, environmental factors in 4.75% children, pets in 8.25% and indoor conditions in 11% children. Skin prick test was positive to egg (13.5%), milk (22%), wheat (9.75%), apple (4.5%), cereals (6.5%), cat (18%), dog (6%), blatella (9.5%), aspergillus fumigatus (9.5%), fungi (12.75%), Dermatophytes farina (24.75%), Dermatophytes pteromyssinus (23.75%), Blomia tropicalis (9.5%) and Bermuda grass (13.75%). Determination of allergen sensitization patterns in children with atopic disease is crucial for selecting proper preventive and therapeutic strategies which helps to improve quality of life of in children.

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Section: Discussionmentioning

confidence: 99%

Evaluation of skin prick test reactivity in children with allergic diseases: A cross sectional study

Kumar¹,

Srikrishna²,

Pavan³

et al. 2021

Int. J. Paediatrics Geriatrics

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Factors associated with secretory IgA levels in colostrum and breastmilk

Mulyani

Winarto

Karyadini

2023

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Background Secretory IgA (sIgA) content of breastmilk in the first postpartum month is a reflection of the pregnant woman's immune response to environmental antigen exposure. The role of secretory IgA in breastmilk is to protect and support the development of the neonatal immune response in early life. Objective To examine possible factors associated with sIgA levels in breastmilk and colostrum, including environmental exposure, food consumed, maternal history of atopy, and the appearance of allergic symptoms in infants. As a secondary objective, we determined the association between infant factors (IgE, exposure to cigarette smoke) and maternal factors (sIgA, maternal allergies) with infant allergies. Methods This prospective cohort study of 80 postpartum mothers and their infants was conducted at Sultan Agung Islamic Hospital, Semarang. We collected maternal colostrum on the second or third postpartum day and mature milk between the 22nd to 25th postpartum day. Exposure factors to mothers and infants in the final trimester of pregnancy up to one month postpartum was recorded through a questionnaire and home visits. The infant’s IgE level was measured at 4 months of age. Results Mean colostrum sIgA was 108.9 (SD 16.5) mg/dL (95%CI 97.9 to 121.1 mg/dL) and mean mature milk sIgA was 94.1 (SD 23.9) mg/dL (95%CI 89.1 to 99.2 mg/dL). Mean colostrum sIgA levels were higher in mothers exposed to cigarette smoke [119.1 (SD 1.7) vs. 92.9 (SD 1.5) mg/dL; P=0.026] and frequent infections [128.2 (SD 1.7) vs. 95.9 (SD 1.6) mg/dL; P=0.007] compared to that in unexposed mothers. Mean colostrum sIgA was also higher in mothers with atopic allergy than in those without (136.8 mg/dL vs. 99.3 mg/dL; p=0.017) and in mothers of infants with IgE levels >29 IU/ml than in mothers of infants with IgE levels <29 IU/mL (136.8 vs. 101.2 mg/mg/dL; P=0.045). Elevated colostrum sIgA (>136.8 mg/dL) was not associated with allergies in the infants (P=0.269). Conclusions Maternal atopic allergy and frequent infections are associated with increased colostrum sIgA levels. Breastmilk sIgA levels are not associated with allergies in the infant. Maternal exposure to antigens may stimulate the production of specific breastmilk sIgA.

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Skin prick test reactivity in atopic children and their number of siblings

Cited by 2 publications

References 1 publication

Evaluation of skin prick test reactivity in children with allergic diseases: A cross sectional study

Evaluation of skin prick test reactivity in children with allergic diseases: A cross sectional study

Factors associated with secretory IgA levels in colostrum and breastmilk

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