Skin Diabetes: Hyperglycodermia Without Hyperglycemia

Urbach, Erich

doi:10.1001/jama.1945.02860400022007

Cited by 26 publications

(9 citation statements)

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“…These data agree with the opinion that skin infections are not related to diabetes [11,13], although some authors report a higher inci dence of skin infections in diabetics [12]. Viral infections were very frequent in dia betics and we were impressed by the high in cidence of herpes simplex virus infections in the children examinated.…”

Section: Commentsupporting

confidence: 87%

“…In the last few years, the pathogenesis of IDD has been par tially explained; the pathogenetic factors which are considered in this condition are genetic susceptibility, viral insults and auto immune factors [1 ]. The association between diabetes and skin diseases has been the sub ject of many studies [2,5,6,8,[11][12][13]; these studies, however, have been carried out mostly on adult patients without considera tion of the type of diabetes involved [2,3,6,11,13]. For these reasons, we planned to in vestigate the skin diseases that are associated with type-1 diabetes in childhood.…”

Section: Introductionmentioning

confidence: 99%

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Diabetes mellitus and Skin Diseases in Childhood

et al. 1985

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Section: Commentsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Diabetes mellitus and Skin Diseases in Childhood

et al. 1985

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“…Blood fructose determinations showed a diminished tolerance to this sugar in acute hepatitis (151). An abnormally high sugar content of the skin in relation to the blood sugar has been ob served in some skin diseases (152). Britton & Kline (153) reported that administration of glucose prolonged the survival of rats exposed to low barometric pressure.…”

Section: Experiments On Intact Animals and Changes In Blood Constituentsmentioning

confidence: 99%

Carbohydrate Metabolism

Cori

1946

Annu. Rev. Biochem.

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A complete survey of papers published in 1945 was made difficult by the inaccessibility of many European journals. With few excep tions, a review. of the carbohydrate metabolism of microorganisms could not be included because of the limitation of space.The increasing importance of isotopes as a tool in biochemistry is reflected in the rapid advances which have been made in inter mediary carbohydrate metabolism with this technique. Isotopes have also been used to great advantage in demonstrating reversibility of enzymatic reactions, particularly those involving carbon. dioxide fixa tion or phosphate transfer. The common metabolic pool for carbon fragments derived from the three principal foodstuffs and their com mon oxidative pathway has made it impossible to discuss the inter mediary metabolism of carbohydrates without some reference to that • of the other foodstuffs.The gap which often exists between results obtained in experi ments on the whole animal and on isolated enzyme systems is being bridged to some extent. Here again the use of isotopes plays a lead ing role, but a unified picture will not emerge until the mechanism of the regulatory effect of hormones on enzyme systems is more clearly understood.The usual abbreviations have been used: ATP and ADP for adenosinetriphosphate and adenosinediphosphate ; TPN and DPN for tri-and diphosphopyridine nucleotide; and P for phosphate.

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“…Abnormal carbohydrate metabolism, atherosclerosis, microangiopathy, neuron degeneration and impaired host mechanism all play roles in the pathogenesis of cutaneous complications. Urbach [4] showed that skin sugar levels run parallel to the blood sugar levels. Cutaneous signs of diabetes mellitus are extremely valuable to the clinician as some of them can alert the physician to the diagnosis of diabetes and also reflect the status of glycemic control and lipid metabolism [5].…”

Section: Introductionmentioning

confidence: 99%