Diabetes mellitus and Skin Diseases in Childhood

Montagnani, A; Tosti, Antonella; Patrizi, A; Salardi, S; Cacciari, E

doi:10.1159/000249500

Cited by 9 publications

(4 citation statements)

References 9 publications

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“…There are conflicting opinions about the relationship between NLD and the presence of microvascular complications (3,6,7). Very few studies have been conducted in children (8,9).…”

mentioning

confidence: 99%

Necrobiosis Lipoidica Diabeticorum in Children and Adolescents: A Clue for Underlying Renal and Retinal Disease

Verrotti

Chiarelli

Amerio

et al. 1995

Pediatric Dermatology

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The prevalence of persistent microalbuminuria, retinopathy, and peripheral and autonomic neuropathy was assessed in 18 children and adolescents with type 1 (insulin-dependent) diabetes mellitus (IDDM) who suffered from necrobiosis lipoidica diabeticorum (NLD) and in 40 diabetics without NLD, matched for sex, age, duration of disease, and metabolic control. The mean +/- SD age of the patients was 15.1 +/- 8.6 years (range 7.9-23.9 yrs) and their duration of IDDM was 10.9 +/- 8.1 years (range 7.1-21.0 yrs). Their mean glycosylated hemoglobin level was 9.9 +/- 5.0% (7.3-16.6%) and their fructosamine level was 274 +/- 180 mumol/L (199-466 mumol/L). Patients with NLD had a higher frequency of persistent microalbuminuria (p < 0.001) and retinopathy (p < 0.001) than those without NLD. Our study suggests that children as well as adult diabetics with NLD can be at high risk for nephropathy and retinopathy; NLD can be a clue for diabetic nephropathy and retinopathy.

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“…There are conflicting opinions about the relationship between NLD and the presence of microvascular complications (3,6,7). Very few studies have been conducted in children (8,9).…”

mentioning

confidence: 99%

Necrobiosis Lipoidica Diabeticorum in Children and Adolescents: A Clue for Underlying Renal and Retinal Disease

Verrotti

Chiarelli

Amerio

et al. 1995

Pediatric Dermatology

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“…This is comparable with the studies by Haider et al and Jaisankar et al where none of the study children had similar diseases. Dawber R 12 and Montagnani et al 13 provided further evidence supporting the association between vitiligo and diabetes mellitus.…”

Section: Discussionmentioning

confidence: 93%

Clinical Study of Vitiligo in Paediatric Population

Chekuri¹,

Pinjala²,

Thakur³

et al. 2016

jebmh

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Vitiligo is an acquired pigmentary anomaly of the skin manifested by depigmented white patches surrounded by a normal or a hyperpigmented border. We studied the clinical profile of vitiligo in paediatric population in Osmania General Hospital over a period of one year from February 2011 to January 2012. METHODS A total of fifty cases of children attending the vitiligo clinic of DVL Department at OGH, Hyderabad were studied. All the children attending the clinic were screened and the sample obtained on fulfilment of the selection criteria. Thirty consecutive adult patients attending the same clinic were taken as controls. This study attempts to identify and understand the features of vitiligo in the paediatric population like clinical spectrum of the disease, demographic features, associated diseases, familial predisposition and to compare all the above to the same features in adult vitiligo patients. RESULTS Out of 50 cases the mean age of the children in the study group was 9.71 yrs. while that of adults in control group was 30.26 yrs. The male female ratio in children was 2.1:2.9 and 7:9 in adults. The predominant site was the extremities mainly the lower limbs followed by face. 60 % of the cases were stable. Trauma was commonest predisposing event associated with 20% of children. CONCLUSIONS In our study the mean age of children at presentation was higher than other studies. Sex distribution was not significant. Course of the disease was found to be stable. The incidence of predisposing factors was found to be higher in children like trauma, febrile illness and contact with colours/paints, etc. The most common clinical variety was generalised and high incidence of dental caries was noted in the study group.

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“…If so, degenerative diseases which result from the impaired expression of tissuespecific functions could result from the repression of tissuespecific gene expression by mechanisms analogous to those described here for Ela and the insulin gene. Indeed, both herpes simplex virus type 1 and cytomegalovirus, another herpesvirus, have been isolated from the pancreas of patients suffering from insulin-dependent diabetes mellitus and have been suggested as pathogenic factors for the disease (27,36,56). The herpes simplex virus type 1 and cytomegalovirus immediate early proteins share certain properties with Ela in transcription assays (14,17,25,26,30,47,48).…”

Section: Discussionmentioning

confidence: 99%

Repression of insulin gene expression by adenovirus type 5 E1a proteins.

Stein¹,

Ziff²

1987

Mol. Cell. Biol.

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Insulin gene transcription relies on enhancer and promoter elements which are active in pancreatic beta cells. We showed that adenovirus type 5 infection of HIT T-15 cells, a transformed hamster beta cell line, represses insulin gene transcription and mRNA levels. Using expression plasmids transiently introduced into HIT T-15 cells, we showed that adenovirus type 5 E1a transcription regulatory proteins repress insulin enhancer-promoter element activity as assayed with a surrogate xanthine-guanine phosphoribosyltransferase gene. We relate E1a repression of the insulin gene to other examples of repression of enhancer-dependent genes by E1a and discuss the possible relationship of this repression to insulin gene regulation.

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Diabetes mellitus and Skin Diseases in Childhood

Cited by 9 publications

References 9 publications

Necrobiosis Lipoidica Diabeticorum in Children and Adolescents: A Clue for Underlying Renal and Retinal Disease

Necrobiosis Lipoidica Diabeticorum in Children and Adolescents: A Clue for Underlying Renal and Retinal Disease

Clinical Study of Vitiligo in Paediatric Population

Repression of insulin gene expression by adenovirus type 5 E1a proteins.

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