Prevalence of Cutaneous Manifestations of Diabetes Mellitus

Verma, Girish Chandra

doi:10.9790/0853-1164147

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…Infections were the most common dermatoses observed in 67% cases, of which fungal infections were most prevalent in 50% cases, followed by bacterial infections in 13% cases and viral infections in 4% cases. This is in accordance with other studies where infections were more common, as observed by Mahajan et al, Chatterjee et al, Verma et al and Pande et al6,8,10,11 This may be because most of our patients belonged to lower socio economic group residing in slum areas where hot and humid conditions, overcrowding and decreased resistance of the body predisposes the individuals for such infections.…”

supporting

confidence: 93%

A study of cutaneous manifestations in diabetes mellitus patients in tertiary care centre

2019

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Background: Diabetes is the most common metabolic disorder with increased prevalence in developing countries like India. It affects almost all organs among which skin is affected by the acute metabolic derangments as well as by chronic degenerative complications. The aims were to study the pattern of cutaneous lesions in patients with diabetes mellitus and to determine the incidence of skin manifestations specific to and associated with diabetics. Methods: Hundred cases of diabetes mellitus with cutaneous manifestations attending skin outpatient department and other patients admitted in medical wards were included in the study. Results: The common skin disorders were cutaneous manifestations (67%), dermatosis more commonly associated with diabetes (36%), neuropathic and ischemic diabetic skin disease (11%). Conclusions: Most common cutaneous manifestation was cutaneous infections followed by dermatosis more commonly associated with diabetes. Among cutaneous infections fungal infections were more common followed by bacterial infections. Cutaneous infections were more common in patients with poor glycaemic control and the association was found to be statistically significant.

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supporting

confidence: 93%

A study of cutaneous manifestations in diabetes mellitus patients in tertiary care centre

2019

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“…This may lead to an underestimation of the prevalence. In studies that screened specifically on AAID, cutaneous manifestations or vitiligo (16,81,82,83,84) in diabetes patients estimated prevalence was higher, 4.3 vs 1.4%, compared to studies that were not actively screening. Vitiligo therefore, may be a common missed diagnosis in many patients with type 1 diabetes as it has limited clinical consequences and therefore active screening is frequently absent.…”

Section: Vitiligomentioning

confidence: 84%

“…Associated antibodies are also frequently found among these patients, sometimes coinciding with overt, but often subclinical disease (7,8). Moreover, it was shown that type 1 diabetes patients have more gastric autoimmunity, vitiligo and adrenal gland insufficiency (9,10,11,12,13,14,15,16,17). It was shown that the pathogenesis of these diseases share common genetic factors and immunologic processes, key to the etiology of the disease (18,19,20,21,22).…”

Section: Introductionmentioning

confidence: 99%

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis

Nederstigt

Uitbeijerse

Janssen³

et al. 2019

European Journal of Endocrinology

102

105

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Introduction:The association between type 1 diabetes (T1D) and other auto-immune diseases is well known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking. Methods: We searched PubMed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo and adrenal gland insufficiency. A meta-analysis was performed to estimate pooled prevalence using a random-effects model. Furthermore, randomeffects meta-regression analysis was performed to assess the association between prevalence and mean age or diabetes duration. Results: One hundred eighty articles were eligible including a total of 293 889 type 1 diabetes patients. Hypothyroidism (65 studies) was prevalent in 9.8% (95% CI: 7.5-12.3) of patients. Meta-regression showed that for every 10-year age increase, hypothyroidism prevalence increased 4.6% (95% CI: 2.6-6.6, P < 0.000, 54 studies). Weighted prevalence of celiac disease was 4.5% (95% CI: 4.0-5.5, 87 studies). Gastric autoimmunity was found in 4.3% of patients (95% CI: 1.6-8.2, 8 studies) and vitiligo in 2.4% (95% CI: 1.2-3.9, 14 studies) of patients. The prevalence of adrenal insufficiency was 0.2% (95% CI: 0.0-0.4, 14 studies) and hyperthyroidism was found in 1.3 percent (95% CI: 0.9-1.8, 45 studies) of type 1 diabetes patients. For all analyses, statistical heterogeneity between studies was moderate to high. Conclusions: The prevalence of antibody-mediated auto-immune disease is high among type 1 diabetes patients. Especially hypothyroidism and celiac disease are frequently found.

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“…Ayrıca kserozis mikroanjiyopati ile ilişkili görünmektedir [14] . Literatürde bazı çalışmalarda %12 gibi düşük oranlarda bildirilirken, bazı çalışmalarda %44-74 gibi yüksek oranlarda ve en sık saptanan dermatolojik belirti olduğu gösterilmiştir [15][16][17] .…”

Section: Discussionunclassified

“…Bu nedenle mikotik infeksiyonların erken tedavisi gerekir [21,23] . Yapılan çalışmalarda fungal infeksiyon sıklığı farklı oranlarda bildirilmiştir [11,15,24] . Diyabetik ayak sendromu gelişmiş hastalarımızın, diğer çalışmalara yakın ve bazı çalışmalara göre ise diyabette mantar infeksiyonlarının sıklığının giderek artmasıyla uyumlu olarak; %28.2'sinde klinik olarak tinea unguium ve tinea pedis saptanmıştır.…”

Section: Discussionunclassified