Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.

Wu, Jiann-Jiu; Lark, Michael W.; Chun, Lawrence; Eyre, David R.

doi:10.1016/s0021-9258(19)67640-4

Cited by 228 publications

(30 citation statements)

References 27 publications

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“…MMP-3 and MMP-13 are important for degrading collagens, proteoglycans and other ECM macromolecules in chondrocytes. MMP-3 may aggravate inflammation via the activation of various pro-MMPs and cleaves extracellular components (24). MMP-13 may also degrade the ECM, including the cartilage-specific component type II collagen during the progression of OA (25).…”

Section: Discussionmentioning

confidence: 99%

Paeoniflorin inhibits IL‑1β‑induced expression of inflammatory mediators in human osteoarthritic chondrocyte

et al. 2017

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Interleukin (IL)-1β serves an important role in the promotion of the growth of osteoarthritis (OA) lesions. Paeoniflorin (PF) has been identified to exert anti‑inflammatory and anti‑arthritic effects. However, it is uncertain whether PF may affect the expression levels of inflammatory mediators in OA chondrocytes. Therefore, the objective of the present study was to determine the effects of PF on the expression levels of inflammatory mediators in IL‑1β‑stimulated human OA chondrocytes. The results of the present study determined that PF inhibited the production of nitric oxide and prostaglandin E2 induced by IL‑1β, and the expression of inducible nitric oxide synthase and cyclooxygenase‑2 in chondrocytes. Additionally, PF significantly inhibited the IL‑1β‑stimulated production of metalloproteinase‑3 (MMP‑3) and MMP‑13 in chondrocytes. PF inhibited the expression of nuclear factor‑κB (NF‑κB), p65 and NF‑κB inhibitor α degradation was induced by IL‑1β in chondrocytes. The results of the present study suggest that PF may inhibit IL‑1β‑induced expression of inflammatory mediators in human OA chondrocytes by suppressing the activation of the NF‑κB signaling pathway. Therefore, PF may be a potential agent in the future treatment of OA.

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Section: Discussionmentioning

confidence: 99%

Paeoniflorin inhibits IL‑1β‑induced expression of inflammatory mediators in human osteoarthritic chondrocyte

et al. 2017

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“…The collagenases are distinguished from the other MMPs by their ability to cleave triple helical regions of cartilage type II collagen. Stromelysin-1 (MMP-3) degrades several ECM molecules, including aggrecan and type II collagen [9][10][11] . In addition, MMP-3 is known to be essential for the full activation of proMMP-1 12 .…”

Section: Introductionmentioning

confidence: 99%

The in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes

Park

Kim

et al. 2003

Osteoarthritis and Cartilage

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“…MMP-3 (also termed stromelysin-1) is a 57/45 kDa (latent/active) enzyme 22 that hydrolyzes a number of extracellular matrix components, including aggrecan, fibronectin, lamnin, collagens III, IV, IX and X [23][24][25] . Moreover, MMP-3 may contribute indirectly to collagen II breakdown by activating other MMPs 26 .…”

Section: Discussionmentioning

confidence: 99%

Is pro-matrix metalloproteinase-3 a marker for posttraumatic cartilage degradation?

Bobacz

Maier²,

Fialka

et al. 2003

Osteoarthritis and Cartilage

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Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.

Cited by 228 publications

References 27 publications

Paeoniflorin inhibits IL‑1β‑induced expression of inflammatory mediators in human osteoarthritic chondrocyte

Paeoniflorin inhibits IL‑1β‑induced expression of inflammatory mediators in human osteoarthritic chondrocyte

The in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes

Is pro-matrix metalloproteinase-3 a marker for posttraumatic cartilage degradation?

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