Simultaneous first derivative UV spectrophotometric estimation of ramipril and olmesartan

Karajgi, Santosh; Simpi, C C; Kalyane, NV

doi:10.5530/rjps.2012.1.11

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Simultaneous UV Spectrophotometric Method for Estimation of Losartan Potassium and Amlodipine Besylate in Tablet Dosage Form has also been reported (Patil, et al, 2009). Simultaneous first derivative UV Spectrophotometric estimation of Ramipril and Olmesartan has also been reported (Karajgi et al, 2012). Simultaneous determination of Atenolol and amlodipine in tablets by high-performance thin-layer chromatography has also been reported (Argekar et al, 2000).…”

Section: Introductionmentioning

confidence: 97%

Simultaneous Estimation of Ramipril and Amlodipine in Bulk and tablet Dosage form by RP-HPLC Method

Rajput¹

2012

J. App. Pharm. Sci.

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A Simple and precise HPLC method was developed for the simultaneous estimation of Ramipril and Amlodipine in pure drug and pharmaceutical dosage forms. The separation was carried out using C18 Column (250 × 4.6 mm i.d. 5 μm particle size), with mobile phase compressing of Acetonitrile, Sodium phosphate buffer and Methanol in the ratio of 50: 20:25 v/v/v, pH= 6.8 (pH adjusted with OPA). The flow rate was 0.8 ml/min and the detection was carried out using PDA detector at 210 nm. The retention times were 2.64 and 7.45 mins for Ramipril and Amlodipine respectively. Calibration curves were linear with correlation coefficient 0.998 and 0.996 over concentration range of 1 -16 µg/ml for Ramipril and 0.2 -3.2 µg/ml for Amlodipine respectively. Recovery was found in between 100.21% and 100.82% for Ramipril and Amlodipine respectively. Method was found to be reproducible with relative standard deviation (R.S.D) for intra and inter day precision less than 2%. The method was validated by evaluation of different parameters such as accuracy, linearity, precision, LOD and LOQ.

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Section: Introductionmentioning

confidence: 97%

Simultaneous Estimation of Ramipril and Amlodipine in Bulk and tablet Dosage form by RP-HPLC Method

Rajput¹

2012

J. App. Pharm. Sci.

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“…The drug is officially listed in the British Pharmacopoeia (), which describes a potentiometric titration procedure for its assay in bulk and dosage form. Several analytical methods have been reported for the assay of ramipril, including spectrophotometric methods (Abdellatef et al ., ; Ayad et al ., , Blaih et al ., ; Karajgi, ; Patil and Rakesh, ; Rahman et al ., ; Salama et al ., ), HPLC (Belal et al ., ; Hogan et al ., ; Patil et al ., , Praveen et al ., ) and HPTLC (Lakshmi et al ., ; Patel et al ., ; Rajput et al ., ; Shah et al ., ). In recent years, FLD and RMP have been successfully used in combination in the treatment of hypertension, and pharmaceutical preparations containing both drugs have been marketed, permitting once‐a‐day administration.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of TLC–densitometric method for simultaneous determination of two binary antihypertensive mixtures containing felodipine in fixed dose combinations

Mohamed

Omar

Hammad

et al. 2015

Biomedical Chromatography

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A new densitometric thin-layer chromatographic method has been developed for simultaneous determination of two binary mixtures containing felodipine in combination with either metoprolol (mixture I) or ramipril (mixture II). The two mixtures were quantitatively separated on 60 F254 silica gel plates using toluene-ethyl acetate-methanol-ammonia as mobile phase with UV detection at 233 and 229 nm for mixtures I and II, respectively. The studied drugs were satisfactorily resolved with retention factor (Rf ) values of 0.34 ± 0.03 and 0.65 ± 0.03 for metoprolol and felodipine, respectively, in mixture I and 0.35 ± 0.03 and 0.74 ± 0.03 for ramipril and felodipine, respectively, in mixture II. Linearity ranges were 2000-7000 and 200-700 ng/band for metoprolol and felodipine, respectively, in mixture I and 1500-4000 ng/band for both ramipril and felodipine in mixture II. Correlation coefficient (r) values were 0.9968 for both metoprolol and felodipine in mixture I and 0.9993 for ramipril and 0.9989 for felodipine in mixture II. The method has been validated according to International Conference on Harmonization guidelines and has been successfully applied for determination of the studied drugs in their dosage forms without interference from commonly encountered excipients.

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Novel Validated UV Spectroscopic Method for the Analysis of Ramipril and Olmesartan medoxomil in Drug Substance as Fixed Dosage Form

Manikandan

2023

RJPT

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The current study focuses on the development and analytical validation of a unique, precise, and accurate UV-Visible Spectrophotometric method for estimating Ramipril and Olmesartan medoxomil simultaneously. The regression strength of Ramipril and Olmesartan medoxomil over its absorbances were obtained as y=0.0378x-0.05347 and y=0.0397x-0.0042 respectively with a correlation coefficient (r2) of 0.9917 for Ramipril and 0.9999 for Olmesartan medoxomil. The intra-day precision in addition inter-day precision for Ramipril and its % RSD were obtained as 1.46% and 1.40% respectively. The intra-day precision in addition inter-day precision for Olmesartan medoxomil and % RSD were obtained as 2.28% and 1.46% respectively.

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Simultaneous first derivative UV spectrophotometric estimation of ramipril and olmesartan

Cited by 3 publications

References 16 publications

Simultaneous Estimation of Ramipril and Amlodipine in Bulk and tablet Dosage form by RP-HPLC Method

Simultaneous Estimation of Ramipril and Amlodipine in Bulk and tablet Dosage form by RP-HPLC Method

Development and validation of TLC–densitometric method for simultaneous determination of two binary antihypertensive mixtures containing felodipine in fixed dose combinations

Novel Validated UV Spectroscopic Method for the Analysis of Ramipril and Olmesartan medoxomil in Drug Substance as Fixed Dosage Form

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