“…Some chromatographic methods have been proposed for its determination at trace levels (Argekar, Sawant, 1999;Argekar, Sawant, 2005), mass spectrometry (Hansen et al, 1985), capillary electrophoresis (Tang et al, 2000), UV spectrometry in a micellar medium (Monferrer-Pons et al, 1996) and Fourier transform infrared spectroscopy (FTIR) (Ventura-Gayete et al, 2006) have also been used. Simultaneous determination of DOX in combination with carbinoxamine maleate by spectrophotometry (MonferrerPons at al., 1996), in combination with dextromethorphan hydrobromide by HPTLC (Indrayanto, 1996), in combination with pseudoephedrine hydrochloride and dextromethorphan hydrobromide by HPLC (Fong, Eickhoff, 1989), and in combination with pyridoxine hydrochloride by HPLC (Argekar, Sawant, 2005) have been reported in the literature. Simultaneous determination of DOX in combination with other antihistamines in pharmaceutical preparations by liquid chromatography with a micelar mobile phase of sodium dodecyl sulfate and pentanol (Paciolla et al, 2001;Gil-Augusti et al, 2001A), of DOX in combination with phenethylamine-antihistamine using C8, C18 or cyano columns with a micellar sodium dodecyl sulfate-pentanol mobile phase (Gil-Augusti et al, 2001B), and of DOX in combination with phenylpropanolamine hydrochloride, chlorpheniramine maleate, dextromethorphan hydrobromide, paracetamol and gaifenesin using ion pair reversed-phase by HPLC, have also been reported.…”