P‐Dimethyl Amino Benzaldehyde as a New Chromogenic Reagent for the Determination of Nonsteroidal Anti‐Inflammatory Drug by First‐Order Derivative Spectrophotometry

Abstract

Mefenamic acid reacts with P-dimethylamino benzaldehyde to give a bluishgreen complex in acidic media after heating for 90 s at 908C, having maximum absorbance at 597.5 nm. The reaction is selective for mefenamic acid with 0.02 mg/10 mL as visual limit of quantitation and provides a basis for a new spectrophotometric determination. The reaction obeys Beer's Law from 0.02 mg to 2.5 mg/10 mL of mefenamic acid and the relative standard deviation is 0.50%. The quantitative assessment of tolerable amounts of other drugs not interfering has also been studied. First-order derivative spectrophotometric procedure was applied for the determination of mefenamic acid in pharmaceutical preparations.

Indirect Spectrophotometric Method for the Determination of Mefenamic Acid in Pharmaceutical Formulations*

“…The most widely used methods for the determination of mefenamic acid are spectrophotometric methods (Idown et al, 2002;Sastry and Rao,1989;Rao, 1987, Dinc et al, 2002;Gangwal et al,1996;Sastry and Rao,1989;Aman et al, 2005, Zommer et al,1986and Alarfaj et al, 2009. However, all of these methods suffer from one or more disadvantage such as insufficient sensitivity, selectivity, tedious and use of complex solvent extraction procedures.…”

Electroanalysis of Mefenamic Acid in Pharmaceutical Formulation and Spiked Biological Fluids on Modified Carbon Nanotube Electrode

“…Due to the vital importance of mefenamic acid, it is essential to develop a simple, rapid and reliable technique for the determination of mefenamic acid. Spectrophotometric [5], solid phase extraction [6], atomic absorption spectrometry [7], NMR [8], chromatography [9][10][11][12][13] and flow injection spectrophotometry [14,15] are several analytical methods developed for the determination of mefenamic acid. Electrochemical techniques are extensively applied due to their sensitive properties and usually they do not require sample pretreatment that is time consuming and difficult [16,17].…”