2002
DOI: 10.1007/bf02491792
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Simultaneous determination of hydrocortisone, oxytetracycline and nystatin by liquid chromatography

Abstract: SummaryA reverse phase high performance liquid chromatographic (HPLC) method to determine Hydrocortisone (HYD), Oxytetracycline (OXY) and Nystatin (NYS) has been developed. The separation was made on a LichrCART | C18 column using methanol-NaH2PO4/Na2HPO4 gradient elution and a diode-array detector measuring at the maximum absorption wavelength for each compound. Quantification limits ranging from 0.19 to 0.85 gg L 1. were obtained. The method was applied to synthetic mixtures and pharmaceutical formulations. … Show more

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Cited by 7 publications
(3 citation statements)
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“…Simultaneous determination of cyclic glycopeptide antibiotics, Zn-bacitracin, corticosteroid prednisolone, and decongestant phenylephrine in local pharmaceutical preparations has been performed by CMEKC in BGE composed of 5 mM phosphate/5 mM borate buffer, pH 8.2, and micellar pseudophase of 40 mM SDS [250]. The LOQ of this simple and rapid (runtime 6.6 min) method was about 1.0 mg/L for each component.…”
Section: Quality Control and Determination Of Puritymentioning
confidence: 99%
“…Simultaneous determination of cyclic glycopeptide antibiotics, Zn-bacitracin, corticosteroid prednisolone, and decongestant phenylephrine in local pharmaceutical preparations has been performed by CMEKC in BGE composed of 5 mM phosphate/5 mM borate buffer, pH 8.2, and micellar pseudophase of 40 mM SDS [250]. The LOQ of this simple and rapid (runtime 6.6 min) method was about 1.0 mg/L for each component.…”
Section: Quality Control and Determination Of Puritymentioning
confidence: 99%
“…Allylestrenol-α-tocopherol tablets, 102 beclomethasone dipropionate inhalers 103 and other formulations (St), 104 betamethasone, its acetate and other corticosteroids in ointments, 105,106 betamethasone and dexamethasone (delicate separation problem! ), 107,108 betamethasone-diclofenac sodium-cyanocobalamine tablet, 109 ethinylestradiol-norgestrel tablet, 114 ethinylestradiollevonorgestrel and ethinylestradiol-gestodene tablets, 117 finasteride tablet (St), 118 fluocortolone pivalate and hexanoate suppositories, 119 hydrocortisone-oxytetracycline-nystatin in pharmaceutical preparations, 120 hydrocortisone acetate and hemisuccinate-lidocaine in pharmaceutical preparations, 121 hydrocortisone acetate-methyl-and propylparaben topical cream (St), 122 hydrocortisone sodium phosphate gel (St), 123 nestorone implants (St), 124 pancuronium bromide injection (St), 125 prednisolone acetate-tetrahydrozoline hydrochlorideofloxacin ophthalmic preparations, 126 prednisolone sodium phosphate implantable infusion pump (St), 127 progesterone in micellar systems and other formulations, 128 triamcinolone, its acetate and acetonide and several other corticosteroids (St), 129 triamcinolone acetonide dermatological patches, 130 triamcinolone acetonide, methyl-and propylparaben topical cream (St). 131 Carefully validated stability-indicating HPLC methods were used for the determination of impurities and degradants in bulk pipecuronium bromide, 132 budesonide, 133 aqueous spironolactone-β-cyclodextrin solutions, 134 and for the photodegradation kinetic study of danazol.…”
Section: ·4 High-performance Liquid Chromatography (Hplc) Andmentioning
confidence: 99%
“…Most of the analytical methods used to study the determination of nystatin are based on electrochemical electrodes [2]; spectrophotometry [3]; densitometry [4]; micellar electrokinetic capillary chromatography [5] and liquid chromatography [6]. Recent research works have been evaluate the effect of nystatin nanoparticles on the physicochemical and antifugal properties [7]; migraine [8] or to improve the oral antifugal properties [9].…”
mentioning
confidence: 99%