Simultaneous determination of cimicifugoside H-2, cimicifugoside H-1, 23-epi-26-deoxyactein, cimigenol xyloside and 25-O-acetylcimigenoside in beagle dog plasma by LC–MS/MS

Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats

“…The low F of Cim A is probably the result of its poor membrane permeability leading to poor intestinal absorption but further studies are needed to verify this. A similar trend was observed for cimicifugosides in dog (Wang et al, 2012). The terminal half-life (t 1/2 ) for Cims A, B and C after oral administration was 5.19 h, which was longer than reported (0.91, 2.67 and 15.5 h) in dog, and the t 1/2 value for Cim D was shorter than that that reported in dog (6.13 h).…”

Simultaneous Determination of Seven Neuroactive Steroids Associated with Depression in Rat Plasma and Brain by High Performance Liquid Chromatography?Tandem Mass Spectrometry

“…[32][33][34] In the present context, matrix effects present a common problem while analyzing compounds in biological samples using LC-MS/MS and may be a major cause of ion suppression. 31,32 These matrix effects can be difficult to eliminate and may negatively affect several analytical parameters such as detection capability, precision, and accuracy.…”