Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats

Gai, Yunyun; Liu, Wanhui; Sha, Chunjie; Wang, Yinglin; Sun, Yuanming; Li, Xiao‐Jiao; Fawcett, J. Paul; Gu, Jingkai

doi:10.1016/j.jep.2012.06.031

Cited by 15 publications

(1 citation statement)

References 21 publications

(20 reference statements)

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“…Moreover, cimicifugin was also able to stimulate epithelial cells and initiate the secretion of cytokines such as IFN-β, to clear the viral infection/load [ 281 ]. Furthermore, another in vitro study conducted by Dai et al, 2016 observed the potential of C. foetida in inhibiting the hepatitis B virus transcription and replication by producing pro-inflammatory cytokines [ 222 ]. Due to the capacity of producing strong pro-inflammatory cytokines and immunomodulatory properties, C. foetida can be used to treat COVID-19 disease.…”

Section: Other Medicinal Plants In Use Against Various Viral Infecmentioning

confidence: 99%

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Siddiqui

Danciu

Ashraf

et al. 2020

Plants

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SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroying the world economy and social life, with increased mortality rate each day. To date, there is no specific medicine or vaccine available against this pandemic disease. However, the presence of medicinal plants and their bioactive molecules with antiviral properties might also be a successful strategy in order to develop therapeutic agents against SARS-CoV-2 infection. Thus, this review will summarize the available literature and other information/data sources related to antiviral medicinal plants, with possible ethnobotanical evidence in correlation with coronaviruses. The identification of novel antiviral compounds is of critical significance, and medicinal plant based natural compounds are a good source for such discoveries. In depth search and analysis revealed several medicinal plants with excellent efficacy against SARS-CoV-1 and MERS-CoV, which are well-known to act on ACE-2 receptor, 3CLpro and other viral protein targets. In this review, we have consolidated the data of several medicinal plants and their natural bioactive metabolites, which have promising antiviral activities against coronaviruses with detailed modes of action/mechanism. It is concluded that this review will be useful for researchers worldwide and highly recommended for the development of naturally safe and effective therapeutic drugs/agents against SARS-CoV-2 infection, which might be used in therapeutic protocols alone or in combination with chemically synthetized drugs.

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Section: Other Medicinal Plants In Use Against Various Viral Infecmentioning

confidence: 99%

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Siddiqui

Danciu

Ashraf

et al. 2020

Plants

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Drug Metabolism and Pharmacokinetic Diversity of Ranunculaceae Medicinal Compounds

Hao¹

2019

Ranunculales Medicinal Plants

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In-depth characterization of cycloartane triterpenoids and discovery of species-specific markers from three Cimicifuga species guided by a strategy that integrates in-source fragment elimination, diagnostic ion recognition, and feature-based molecular networking

Yu,

Chen,

Liu

et al. 2024

Journal of Chromatography A

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Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats

Cited by 15 publications

References 21 publications

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Drug Metabolism and Pharmacokinetic Diversity of Ranunculaceae Medicinal Compounds

In-depth characterization of cycloartane triterpenoids and discovery of species-specific markers from three Cimicifuga species guided by a strategy that integrates in-source fragment elimination, diagnostic ion recognition, and feature-based molecular networking

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