Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga : A review

Guo, Yaqing; Yin, Tongming; Wang, Xiaoming; Zhang, Fan; Pan, Guixiang; Lü, Hong; Wang, Xianrui; Orgah, John; Zhu, Yan; Wu, Hong‐Hua

doi:10.1016/j.jep.2017.07.040

Cited by 61 publications

(49 citation statements)

References 122 publications

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“…Actaea racemosa is a well-established medicinal plant, which was investigated for its effectiveness and safety in around 20 clinical studies involving over 6000 patients [6]. Due to its frequent use in the treatment of climacteric complaints, with a daily intake of approximately 1 mg triterpenoids [7], and its thus resulting medicinal and commercial importance, black cohosh was the target of various other pharmacological and toxicological studies [14]. Most of these studies focused on extracts, fractions, or on the main compounds, such as actein (1) or 23-epi-26-deoxyactein.…”

Section: Discussionmentioning

confidence: 99%

“…Cimigenol-type triterpenoids represent one of the major triterpenoid classes in black cohosh and several other Actaea species [8,14]. In Actaea racemosa, cimigenol-3-O-α-l-arabinopyranoside (5) and cimigenol-3-O-β-d-xylopyranoside (6) display two of the most abundant triterpenoids [22], but also a large number of derivatives have been reported to be present in the rootstock [8].…”

Section: Discussionmentioning

confidence: 99%

“…Because of the hormone-like activity of black cohosh preparations, an estrogen-receptor mediated activity was initially assumed, but the alleviating effects are rather the result of GABA(A)-receptor modulation [9,10]. In the same context, black cohosh triterpenoids actein (1) and 23-epi-26-deoxyactein were found to exhibit beneficial effects against postmenopausal osteoporosis promoting cell growth and differentiation of osteoblast as well as osteocalcin production and mineralization [11][12][13], thus confirming the use of black cohosh for climacteric complaints [14].…”

Section: Introductionmentioning

confidence: 86%

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Structure-Guided Identification of Black Cohosh (Actaea racemosa) Triterpenoids with In Vitro Activity against Multiple Myeloma

et al. 2020

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Black cohosh is a well-established medicinal plant and preparations of its rootstock are used for the treatment of mild climacteric complaints. The compounds considered responsible for the therapeutic effect are triterpene glycosides, characterized by a cycloartane scaffold and a pentose moiety. Because some of these triterpenoids were found to exhibit relevant cytotoxic effects against human breast cancer cells, we decided to investigate their activity on multiple myeloma cell lines NCI-H929, OPM-2, and U266. In a systematic approach, we initially tested three known cytotoxic compounds of three different triterpenoid types, revealing the cimigenol-type triterpenoid as the most active constituent. In a second round, seven naturally occurring cimigenol derivatives were compared with respect to their sugar moiety and their substitution pattern at position C-25, leading to 25-O-methylcimigenol-3-O-α-L-arabinopyranoside as the most potent candidate. Interestingly, not only the methyl group at position C-25 increased the cytotoxic effect but also the arabinose moiety at position C-3 had an impact on the activity. The variety of cimigenol derivatives, moreover, allowed a detailed discussion of their structure-activity relationships, not only for their effect on multiple myeloma cells but also with regard to previous studies on the cytotoxicity of black cohosh triterpenoids.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

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Structure-Guided Identification of Black Cohosh (Actaea racemosa) Triterpenoids with In Vitro Activity against Multiple Myeloma

et al. 2020

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“…The genus Cimicifuga has been widely used in China, Europe and North America for its high medicinal value (Guo et al, ). Their dried rhizomes have long been in common usage for the treatment of wind‐heat headache, toothache, aphtha, sore throat, measles, spot poison and uterine prolapse (Guo et al, ). Their health‐promoting and therapeutic values have been corroborated by long‐term use in folk medicine and daily diet (Hao et al, ; Qin et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…For example, the alcoholic extract of C. foetida (brand name Ximingting ® ) was approved for the treatment of perimenopausal symptoms by China State Food and Drug Administration in 2005 (Ye et al, ). Against this background, there is rising concern about the quality control of Cimicifugae Rhizoma, including adopting HPLC and near‐infrared diffuse reflectance spectroscopy methods (Fang et al, ; Guo et al, ; Shen et al, ; Wu et al, ). However, related research is still limited.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of 19 constituents in Cimicifugae Rhizoma by HPLC–DAD and screening for antioxidants through DPPH free radical scavenging assay

Niu

Qin

Zhao

et al. 2019

Biomedical Chromatography

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Cimicifugae Rhizoma (sheng ma) is a well-known traditional Chinese medicine, which has been demonstrated to possess anti-inflammatory, antipyretic and analgesic activities. In the present study, a simple and efficient HPLC-DAD (high-performance liquid chromatography coupled with diode array detection) method was developed and validated for simultaneous quantification of 19 chemical components (including 16 phenolic acids, one coumarin and two alkaloids) in Cimicifugae Rhizoma. The result indicated that this method could effectively evaluate the quality of Cimicifugae Rhizoma and provide a valuable reference for further study. Additionally, the antioxidant activity of Cimicifugae Rhizoma was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl) radical scavenging assay. The results showed that the content of phenolic acids and antioxidant activity exhibited significant correlation coefficients.

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Comparative in vivo pharmacokinetics study of affeic acid, isoferulic acid and ferulic acid in crude and three different prepared Cimicifuga foetida L.

et al. 2020

Biomedical Chromatography

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Our study investigated the differences in pharmacokinetics of three major components of crude Cimicifuga foetida L. and its fried product and honey‐ and liquor‐prepared products. A rapid and sensitive ultra‐high performance liquid chromatography with tandem mass spectrometry approach was established for determing caffeic acid, isoferulic acid and ferulic acid in rat plasma. The approach has good linearity, precision, accuracy, recovery and stability. Phenolic acid was rapidly absorbed. The times to peak concentration were shorter in the processed group than those for the crude product, with their values of <30 min. The peak concentration values of caffeic acid and isoferulic acid were higher in the crude group than in the processed groups (p < 0.05). Area under the curve values of the three phenolics in the crude group were significantly higher than those of the processed groups (p < 0.05).

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Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga : A review

Cited by 61 publications

References 122 publications

Structure-Guided Identification of Black Cohosh (Actaea racemosa) Triterpenoids with In Vitro Activity against Multiple Myeloma

Structure-Guided Identification of Black Cohosh (Actaea racemosa) Triterpenoids with In Vitro Activity against Multiple Myeloma

Simultaneous determination of 19 constituents in Cimicifugae Rhizoma by HPLC–DAD and screening for antioxidants through DPPH free radical scavenging assay

Comparative in vivo pharmacokinetics study of affeic acid, isoferulic acid and ferulic acid in crude and three different prepared Cimicifuga foetida L.

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