Silver nanoparticles: Evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells

Toxicity, bioaccumulation and biomagnification of silver nanoparticles in green algae (Chlorellasp.), water flea (Moina macrocopa), blood worm (Chironomusspp.) and silver barb (Barbonymus gonionotus)

“…Particle characteristic of most silver nanoparticles were spherical in shape as well as being elongated (Hackenberg et al, 2011). Particle size distribution analysis showed that the particle size of AgNPs in this study was less than 100 nm.…”

Silver nanoparticles: cytotoxic, apoptotic, and necrotic effects on MCF-7 cells

“…It is well known that ROS are highly reactive and cause oxidative harm to DNA and cell enzymes (Turrens, 2003;Boonstra and Post, 2004). Generation of excessive intracellular ROS leads to apoptosis and necrosis Hackenberg et al, 2011), evidenced by the fact that an increase in ROS levels is correlated with massive DNA breakage and high levels of apoptosis and necrosis (Foldbjerg et al, 2009;Singh and Ramarao, 2012). However, the cytotoxic effects may be partially due to direct action of Ag + ions released from AgNPs.…”

Micromorphological cellular responses of MC3T3-E1 and RAW264.7 after exposure to water-dispersible silver nanoparticles stabilized by metal-carbon σ-bonds

“…Hackenberg et al 33) have shown, using TEM, that Ag-NPs translocate into the nuclei of human mesenchymal stem cells. Another TEM study showed the presence of Ag-NPs in nuclei and nucleoli of human lung fibroblasts and human glioblastoma cells 34) .…”