Silver Nanoparticles Anchored 5-methoxy benzimidazol thiomethanol (MBITM): Modulate, Characterization and Comparative Studies on MBITM and Ag-MBITM Antibacterial Activities

Abstract

This research highlights the synthesis of novel organic molecule that is 5-methoxybenzimidazolthiomethanol (MBITM). This molecule is synthesized via the reaction of 5-Methoxy-2-mercaptobenzimidazole with formaldehyde in ethanol. This resulting molecule was characterized via Fourier-transform infrared spectroscopy (FTIR), proton-nuclear magnetic resonance (1H-NMR) and elemental analysis (CHN). Furthermore, MBITM is used as a base compound for preparation of one novel nano material by mixing it with silver nanoparticles (Ag NPs) that prepared by green method using Zizyphus spina christi L (Seder) leaf, via a simple chemical reaction. The resulting Ag anchored MBITM (Ag-MBITM) was characterized by FTIR, X-ray diffraction (XRD) and Energy-dispersive X-ray spectroscopy (EDX) measurements. All these characterization measurements establish that a stable MBITM can be electrostatically retained on the surfaces of the Ag NPs. MBITM, Ag NPs and their nano derivative were screened for their antibacterial activity against both types of bacteria Gram-positive (S. aureus) and Gram-negative (E. Coli). In general, E-Coli and S. aureus were exposed to be significantly inhibited by all these three compounds but with different inhibition levels. Besides, the study of the biological activity was adopted for the purpose of conducting a comparative study between the raw materials (Ag NPs, MBITM) and the nanomaterial (Ag-MBITM) resulting from their reaction. The results showed that nanosilver-organic hybrid had effectively developed the antibacterial ability for both starting compounds. It has also been observed that this hybrid has been particularly effective with respect to the gram-positive bacteria.

The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action

“…Evaluation of silver nanoparticles (AgNPs) involves various types of analytical techniques which includes X-ray diffractometry (XRD) at wavelength (λ) = 1.54056 Å, X-ray photoelectron spectroscopy (XPS) usually between 300-400 eV, Fourier transform infrared spectroscopy (FTIR) in wavelength range of 400-4000 cm −1 , ultraviolet visible spectroscopy (UV-vis spectroscopy) at the range of 400-500 nm, transmission electron microscopy (TEM), scanning electron microscopy (SEM), dynamic light scattering (DLS) at scattering angle of 173 • , and localized surface plasma resonance (LSPR) at wavelength of 300 nm to 1100 nm [4]. These analyses are important to assess the behavior, bio-distribution, and reactivity of these fabricated nanoparticles.…”

Morphological Properties of Nanocrystalline Silicon from p‐Type Bulk Silicon

“…[12][13][14] Figure 3 shows the layer thickness of porous silicon as a function of etching time, from this figure one can recognize the formations layer thickness and after that can see the polishing of that layer the short time between these two states may be because the high concentration of the acid HF/ethanol (2:1), which make strong reaction between the acid and bulk silicon which make the layer thickness of porous silicon and gradually decreases because of the polishing occurs, after that the reaction between the acid and bulk silicon become slow because the depletion in the reaction charge and this cause increased in the new layer thickness bigger than the first, the layer thickness and this result can be shown in many types of research. [15][16][17] Due to the importance of the SEM images in the determination of the morphology, [18][19][20][21][22][23][24][25][26][27] therefore the SEM for the samples can be seen in Figure 4a-c, these figures show the porous silicon as preparation with etching time 2, 6, and 10 min, respectively, from Figure 4a one can see the porous silicon formation which can show the air pores and nanocrystalline silicon that is in the beginning, (Figure 4b) sample under etching time 6 min shows the removing porous silicon layer and the shot down on the reaction charges, which affect on the etching rate and layer thickness and then on the porosity, after removing layer thickness the layer thickness makes a new porous silicon layer but with new reaction, which makes new energy levels between the acid and bulk silicon due to quantum confinement effect, this results can be shown in many papers. [28][29][30]…”

Synthesis, Characterization, and Bacterial Activity of Co(II), Ni(II), and Pd(II) Complexes with Ligands of Thymine, Uracil Thiuram Disulfur, and Cyclic Amines

“…Such increased activity of the metal complexes can also be explained on the basis of chelation theory. [ 26–30 ] According to this, the chelation reduces the polarity of the metal ion mainly because of the partial sharing of its positive charge with donor group and possible‐electron delocalization over the whole ring. This increases the lipophilic character of the metal chelate system, which favors its permeation through lipid layer of the cell membranes (see Figure ).…”