This research highlights the synthesis of novel organic molecule that is 5-methoxybenzimidazolthiomethanol (MBITM). This molecule is synthesized via the reaction of 5-Methoxy-2-mercaptobenzimidazole with formaldehyde in ethanol. This resulting molecule was characterized via Fourier-transform infrared spectroscopy (FTIR), proton-nuclear magnetic resonance (1H-NMR) and elemental analysis (CHN). Furthermore, MBITM is used as a base compound for preparation of one novel nano material by mixing it with silver nanoparticles (Ag NPs) that prepared by green method using Zizyphus spina christi L (Seder) leaf, via a simple chemical reaction. The resulting Ag anchored MBITM (Ag-MBITM) was characterized by FTIR, X-ray diffraction (XRD) and Energy-dispersive X-ray spectroscopy (EDX) measurements. All these characterization measurements establish that a stable MBITM can be electrostatically retained on the surfaces of the Ag NPs. MBITM, Ag NPs and their nano derivative were screened for their antibacterial activity against both types of bacteria Gram-positive (S. aureus) and Gram-negative (E. Coli). In general, E-Coli and S. aureus were exposed to be significantly inhibited by all these three compounds but with different inhibition levels. Besides, the study of the biological activity was adopted for the purpose of conducting a comparative study between the raw materials (Ag NPs, MBITM) and the nanomaterial (Ag-MBITM) resulting from their reaction. The results showed that nanosilver-organic hybrid had effectively developed the antibacterial ability for both starting compounds. It has also been observed that this hybrid has been particularly effective with respect to the gram-positive bacteria.

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This research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution. The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2). A number of hydrazones (N3-N5) were prepared through the reaction of N2 with different benzaldehydes. The compound (N6) was also prepared whereby the ring closing of hydrazone (N3) using chloroacetylchloride, while the compound (N7) was prepared by treating 2-hydrazino benzoxazole with acetylacetone. When the compound (N1) was treated with formaldehyde, it afforded the compound (N8). Also, the N9 was obtained from the reaction of N1 with chloroacetic acid in the presence of alcoholic potassium hydroxide. The prepared compounds were characterized using physico-chemical and spectroscopic methods such as melting point, infrared spectroscopy (IR) and the proton nuclear magnetic resonance (1H-NMR). Thereafter, some of the compounds were selected for in vitro antibacterial activity and one of these compounds showed an inhibition effect against gram positive only which is very important because it is considered as specific antibacterial drug.

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