Silicon multi-nanochannel FETs to improve device uniformity/stability and femtomolar detection of insulin in serum

Regonda, Suresh; Tian, Ruhai; Gao, Jinming; Greene, Serena; Ding, Jindong; Hu, Walter

doi:10.1016/j.bios.2013.01.027

Cited by 67 publications

(54 citation statements)

References 40 publications

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“…When chemically modified in a multiplexed mode, by the surface immobilization of multiple non-specific small chemical receptors, nanowire-based fieldeffect-transistor arrays (NW-FETs) enable the supersensitive discriminative detection, fingerprinting, of multiple explosive molecules, down to the parts-per-quadrillion concentration range 19 . The differential identification between explosives is achieved by pattern recognizing the naturally inherent interaction, both kinetically and thermodynamically [20][21][22][23][24][25][26][27] , between the chemically modified nanosensors array and the chemical analytes under test.…”

mentioning

confidence: 99%

Supersensitive fingerprinting of explosives by chemically modified nanosensors arrays

Lichtenstein¹,

Havivi²,

Shacham³

et al. 2014

Nat Commun

175

128

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The capability to detect traces of explosives sensitively, selectively and rapidly could be of great benefit for applications relating to civilian national security and military needs. Here, we show that, when chemically modified in a multiplexed mode, nanoelectrical devices arrays enable the supersensitive discriminative detection of explosive species. The fingerprinting of explosives is achieved by pattern recognizing the inherent kinetics, and thermodynamics, of interaction between the chemically modified nanosensors array and the molecular analytes under test. This platform allows for the rapid detection of explosives, from air collected samples, down to the parts-per-quadrillion concentration range, and represents the first nanotechnology-inspired demonstration on the selective supersensitive detection of explosives, including the nitro-and peroxide-derivatives, on a single electronic platform. Furthermore, the ultrahigh sensitivity displayed by our platform may allow the remote detection of various explosives, a task unachieved by existing detection technologies.

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mentioning

confidence: 99%

Supersensitive fingerprinting of explosives by chemically modified nanosensors arrays

Lichtenstein¹,

Havivi²,

Shacham³

et al. 2014

Nat Commun

175

128

View full text Add to dashboard Cite

show abstract

“…Detection of tumor biomarkers for breast cancer [52,53], hepatic carcinoma [54], oral squamous cell carcinoma [55], pancreatic cancer [56], and bladder cancer [57] have also been reported. Moreover, other disease biomarkers related to cardiovascular diseases [58][59][60], thyroid hormone [61], venous thromboembolism [62], Alzheimer [63], and diabetes [64,65] have been detected with very low detection limits. Table 2 evidences the ultrasensitive detection of pathogenic microorganisms associated with human health and food safety, such as Salmonella [66,67] and Escherichia coli [68][69][70][71] bacteria, rotavirus [72] and bacteriophage [69] viruses, and parasitic protozoan [73].…”

Section: Trends In Fet-based Immunosensors Using Nanomaterials As Senmentioning

confidence: 99%

“…An alternative to these drawbacks was demonstrated by using silicon nanogratings (SiNG) rather than SiNW [64]. The SiNG devices were fabricated using p-doped silicon-on-insulator substrates that were subjected to etching steps, thermal surface oxidation, and annealing.…”

Section: Other Nanomaterials/other Reports Of Interestmentioning

confidence: 99%

Recent Trends in Field-Effect Transistors-Based Immunosensors

Moraes

Kubota

2016

Chemosensors

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Abstract:Immunosensors are analytical platforms that detect specific antigen-antibody interactions and play an important role in a wide range of applications in biomedical clinical diagnosis, food safety, and monitoring contaminants in the environment. Field-effect transistors (FET) immunosensors have been developed as promising alternatives to conventional immunoassays, which require complicated processes and long-time data acquisition. The electrical signal of FET-based immunosensors is generated as a result of the antigen-antibody conjugation. FET biosensors present real-time and rapid response, require small sample volume, and exhibit higher sensitivity and selectivity. This review brings an overview on the recent literature of FET-based immunosensors, highlighting a diversity of nanomaterials modified with specific receptors as immunosensing platforms for the ultrasensitive detection of various biomolecules.

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“…As demonstrated recently [8,[32][33][34][35], such multi-wire devices, assembled using a thin-film-transistor (TFT) format, reveal remarkably high output currents (up to~mA) preserving the high on-to-off current ratio (in average up to~10 6 ), which greatly outperform the single wire FET, mostly employed for biosensor measurements [33]. Thus, devices connected by NW arrays are able to deliver a broader dynamic range for the measurements and lower device-to-device variation in current and sensitivity due to the averaging of the different signals coming from the individual wires [36,37]. These aspects are critically important for ISFET devices in general and are considered to be typical drawbacks of sensors encompassing individual nanowire channels, in particular.…”

Section: Introductionmentioning

confidence: 99%

Gating Hysteresis as an Indicator for Silicon Nanowire FET Biosensors

et al. 2018

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Abstract:We present a biosensor chip with integrated large area silicon nanowire-based field effect transistors (FET) for human α-thrombin detection and propose to implement the hysteresis width of the FET transfer curve as a reliable parameter to quantify the concentration of biomolecules in the solution. We further compare our results to conventional surface potential based measurements and demonstrate that both parameters distinctly respond at a different analyte concentration range. A combination of the two approaches would provide broader possibilities for detecting biomolecules that are present in a sample with highly variable concentrations, or distinct biomolecules that can be found at very different levels. Finally, we qualitatively discuss the physical and chemical origin of the hysteresis signal and associate it with the polarization of thrombin molecules upon binding to the receptor at the nanowire surface.

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Silicon multi-nanochannel FETs to improve device uniformity/stability and femtomolar detection of insulin in serum

Cited by 67 publications

References 40 publications

Supersensitive fingerprinting of explosives by chemically modified nanosensors arrays

Supersensitive fingerprinting of explosives by chemically modified nanosensors arrays

Recent Trends in Field-Effect Transistors-Based Immunosensors

Gating Hysteresis as an Indicator for Silicon Nanowire FET Biosensors

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