Gating Hysteresis as an Indicator for Silicon Nanowire FET Biosensors

Ibarlucea, Bergoi; Römhildt, Lotta; Zörgiebel, F.; Pregl, Sebastian; Vahdatzadeh, Maryam; Weber, Walter M.; Mikolajick, Thomas; Opitz, Jörg; Baraban, Larysa; Cuniberti, Gianaurelio

doi:10.3390/app8060950

Cited by 21 publications

(28 citation statements)

References 63 publications

(77 reference statements)

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“…[14,37] This distance becomes shorter with the increase in the ionic strength. Particularly in FETs, the response depends on the charge sign of the analyte molecule and the transistor type (n or p).…”

Section: Sensing Biomolecules: Toward Miniaturized Point-of-care Diagmentioning

confidence: 94%

Section: Alternative Measurement Modesmentioning

confidence: 99%

“…[171] Copyright 2013, ACS Publications. [55] single virus (Influenza A), [48] single proteins (Influenza A Virus Hemagglutinin) [158] Aptamer 10 × 10 −12 m (dopamine), [171] 200 × 10 −12 m (α-thrombin) [37] DNA 1 × 10 −15 m (25-mer DNA), [159] 40 × 10 −12 m (18-mer DNA) [92] PNA 10 × 10 −15 m (31-mer DNA) [44] γ-pyrone 50 × 10 −15 m Fe 3+ [126] Thiamine 40 × 10 −12 m (human prion protein PrP c ) [176] Glycan 50 × 10 −18 m (Influenza A Virus Hemagglutinin) [177] Ni 2+ quelated on AB-NTA Single His-tag F1-ATPase motor protein [156] AB-NTA: Nα,Nα-bis(carboxymethyl)-l-lysine. The increase in the mobility of the receptor due to low density improves the probability of falling inside the Debye limit.…”

Section: Alternative Measurement Modesmentioning

confidence: 99%

“…Finally, Si/ SiO x offers the chemistry possibilities for easy integration of biological receptors and more specific detection. [35][36][37] Many of them, including alternative fabrication [38][39][40] and measuring [37,41,42] methods, will be reviewed here. [31] In a classical metal-oxide-semiconductor field-effect transistor (MOSFET), the gate terminal is in direct contact with a thin dielectric layer that surrounds the semiconductor channel.…”

Section: Introductionmentioning

confidence: 99%

“…[10,26,32,[46][47][48][49][50][51] As a first application, [43] Lieber's group modified the surface using 3-aminopropyltriethoxysilane (APTES), obtaining a double surface functionality with the amino groups from APTES and the hydroxyl groups from the silicon dioxide surface. [45] Inspired by these works, myriads of publications have exploited the broad range of possibilities in SiNW sensorics (Figure 1), from detection of biomolecules for diagnostic purposes [36,37,[52][53][54][55] to recording of cell activity, [46,[56][57][58][59][60][61] intracellular signal control, [49,62,63] tissue monitoring, [4,25] food safety, [64] and gas [65,66] and explosive sensing. They also functionalized the surface with biotin for specific detection of streptavidin, obtaining detection capabilities down to 10 × 10 −12 m. Only 3 and 4 years later, they could demonstrate large arrays of individually addressable sensors for multiplexed detection of single viruses [48] and protein markers at femtomolar concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Hybrid Silicon Nanowire Devices and Their Functional Diversity

et al. 2019

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In the pool of nanostructured materials, silicon nanostructures are known as conventionally used building blocks of commercially available electronic devices. Their application areas span from miniaturized elements of devices and circuits to ultrasensitive biosensors for diagnostics. In this Review, the current trends in the developments of silicon nanowire‐based devices are summarized, and their functionalities, novel architectures, and applications are discussed from the point of view of analog electronics, arisen from the ability of (bio)chemical gating of the carrier channel. Hybrid nanowire‐based devices are introduced and described as systems decorated by, e.g., organic complexes (biomolecules, polymers, and organic films), aimed to substantially extend their functionality, compared to traditional systems. Their functional diversity is explored considering their architecture as well as areas of their applications, outlining several groups of devices that benefit from the coatings. The first group is the biosensors that are able to represent label‐free assays thanks to the attached biological receptors. The second group is represented by devices for optoelectronics that acquire higher optical sensitivity or efficiency due to the specific photosensitive decoration of the nanowires. Finally, the so‐called new bioinspired neuromorphic devices are shown, which are aimed to mimic the functions of the biological cells, e.g., neurons and synapses.

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Section: Sensing Biomolecules: Toward Miniaturized Point-of-care Diagmentioning

confidence: 94%

Section: Alternative Measurement Modesmentioning

confidence: 99%

Section: Alternative Measurement Modesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hybrid Silicon Nanowire Devices and Their Functional Diversity

et al. 2019

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Hydrogel‐Gated Silicon Nanotransistors for SARS‐CoV‐2 Antigen Detection in Physiological Ionic Strength

Parichenko

Choi

Shin

et al. 2023

Adv Materials Inter

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The recent Coronavirus Disease 2019 (COVID‐19) outbreak strongly propels advancements in biosensor technology, leading to the emergence of novel methods for virus detection. Among them, those using nanostructured field‐effect transistors (FETs) provide an ultrasensitive approach toward point‐of‐care diagnostics. However, the application of these biosensors in analyzing biofluids has been limited by their reduced screening length in high ionic strength liquids. To address this challenge, a solution is presented involving the surface modification of FETs with a hydrogel based on star‐shaped polyethylene glycol. This hydrogel is loaded with specific antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein. By incorporating the hydrogel, the effective Debye length is effectively increased, thereby preserving the sensitivity in biofluids. The efficacy of this approach is demonstrated by employing silicon nanonet‐based FETs for the detection of viral antigens in both buffer and saliva, as well as cultured viral particle dispersions. Moreover, positive and negative patient samples are successfully differentiated, showcasing the practical application of this method. Finally, a theoretical frame is proposed to elucidate the underlying mechanism behind the preservation of sensitivity.

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Aptamer‐functionalized field‐effect transistor biosensors for disease diagnosis and environmental monitoring

et al. 2023

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Nano-biosensors that are composed of recognition molecules and nanomaterials have been extensively utilized in disease diagnosis, health management, and environmental monitoring. As a type of nano-biosensors, molecular specificity field-effect transistor (FET) biosensors with signal amplification capability exhibit prominent advantages including fast response speed, ease of miniaturization, and integration, promising their high sensitivity for molecules detection and identification. With intrinsic characteristics of high stability and structural tunability, aptamer has become one of the most commonly applied biological recognition units in the FET sensing fields. This review summarizes the recent progress of FET biosensors based on aptamer functionalized nanomaterials in medical diagnosis and environmental monitoring. The structure, sensing principles, preparation methods, and functionalization strategies of aptamer modified FET biosensors were comprehensively summarized. The relationship between structure and sensing performance of FET biosensors was reviewed. Furthermore, the challenges and future perspectives of FET biosensors were also discussed, so as to provide support for the future development of efficient healthcare management and environmental monitoring devices.

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Gating Hysteresis as an Indicator for Silicon Nanowire FET Biosensors

Cited by 21 publications

References 63 publications

Hybrid Silicon Nanowire Devices and Their Functional Diversity

Hybrid Silicon Nanowire Devices and Their Functional Diversity

Hydrogel‐Gated Silicon Nanotransistors for SARS‐CoV‐2 Antigen Detection in Physiological Ionic Strength

Aptamer‐functionalized field‐effect transistor biosensors for disease diagnosis and environmental monitoring

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