Significant association of XRCC4 single nucleotide polymorphisms with prostate cancer susceptibility in Taiwanese males

Chang, Chao Hsiang; Chiu, Chang Fang; Wu, Hsi Chin; Tseng, Hsien Chang; Wang, Chung Hsing; Lin, Cheng Chieh; Tsai, Chia Wen; Liang, Shiu Yun; Wang, Cheng Li; Bau, Da Tian

doi:10.3892/mmr.1.4.525

Cited by 41 publications

(52 citation statements)

References 14 publications

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“…Previous studies indicated that polymorphism of CSB rs2228526 was associated with susceptibility and prognosis of various cancer, such as skin cancer, bladder cancer and bone malignant tumor as well as glioblastoma (Chang et al, 2009;Grunda et al, 2010;Wheless et al, 2012;Sun et al, 2013). Another experimental study indicated that chronic exposure to arsenic causes DNA damage and increased cell survival that may ultimately result in neoplastic transformation of human prostate epithelial cells (Singh et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Role of DNA Repair-related Gene Polymorphisms in Susceptibility to Risk of Prostate Cancer

Yang¹,

Wen²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Role of DNA Repair-related Gene Polymorphisms in Susceptibility to Risk of Prostate Cancer

Yang¹,

Wen²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…However, further studies are still required to confirm this predicted biological significance. By reviewing the currently available literatures on ERCC6 polymorphisms, we noted that associations of another frequently-reported SNP rs2228528 with different cancers have been described including oral cancer (Chiu et al, 2008), lung cancer (Ma et al, 2009) and bladder cancer (Chang et al, 2009). The rs2228528 polymorphism located in the exon 5 of ERCC6 gene is in highly linkage disequilibrium with the currently-investigated SNP rs1917799 (r 2 =0.95, derived from CHB genotype data of HapMap Project).…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, disruption of this gene was related to the development of age-related macular degeneration (Tuo et al, 2006). Quite recently, genetic variations of ERCC6 have been linked to the susceptibility to various cancers, including lung cancer (Lin et al, 2008;Ma et al, 2009), breast cancer (Mechanic et al, 2006;Rajaraman et al, 2008), prostate cancer (Hooker et al, 2008), bladder cancer (Chen et al, 2007;Chang et al, 2009) and colorectal cancer Huang et al, 2006). However, the relation of ERCC6 polymorphism with gastric cancer risk is still unclear, which deserves to be further clarified.…”

Section: Research Articlementioning

confidence: 99%

The DNA Repair Gene ERCC6 rs1917799 Polymorphism is Associated with Gastric Cancer Risk in Chinese

Liu

He²,

Sun³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: Excision repair cross-complementing group 6 (ERCC6) is a major component of the nucleotide excision repair pathway that plays an important role in maintaining genomic stability and integrity. Several recent studies suggested a link of ERCC6 polymorphisms with susceptibility to various cancers. However, the relation of ERCC6 polymorphism with gastric cancer (GC) risk remains elusive. In this sex-and age-matched case-control study including 402 GC cases and 804 cancer-free controls, we aimed to investigate the association between a potentially functional polymorphism (rs1917799 T>G) in the ERCC6 regulatory region and GC risk. Methods: The genotypes of rs1917799 were determined by Sequenom MassARRAY platform and the status of Helicobacter pylori infection was detected by enzyme-linked immunosorbent assay. Odd ratios (ORs) and 95% confidential interval (CI) were calculated by logistic regression analysis. Results: Compared with the common TT genotype, the ERCC6 rs1917799 GG genotype was associated with increased GC risk (adjusted OR=1.46, 95%CI: 1.03-2.08, P=0.035). When compared with (GT+TT) genotypes, the GG genotype also demonstrated a statistical association with increased GC risk (adjusted OR=1.38, 95%CI: 1.01-1.89, P=0.044). This was also observed for the male subpopulation (GG vs. TT: adjusted OR=1.71, 95%CI: 1.12-2.62, P=0.013; G allele vs. T allele: adjusted OR=1.32, 95%CI: 1.07-1.62, P=0.009). Genetic effects on increased GC risk tended to be enhanced by H. pylori infection, smoking and drinking, but their interaction effects on GC risk did not reach statistical significance. Conclusions: ERCC6 rs1917799 GG genotype might be associated with increased GC risk in Chinese, especially in males.

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“…So, risky genotypes have an effect on cancer susceptibility [20]. Wu et al [32] reported 12 missense single nucleotide polymorphisms in the EXO1 gene including K589E in exon11 [21][22][23][24][25][26][27][28][29][30][31][32]. An exonic SNP doesn't necessarily cause a dysfunctional protein.…”

Section: Introductionmentioning

confidence: 99%

“…Genetic polymorphisms in DNA repair genes such as EXO1 are thought to modulate DNA repair capacity and consequently are suggested to be associated with colorectal cancer [22]. Singlenucleotide polymorphism (SNP) is a DNA sequence variation and has a great potential application to determine association with susceptibility to several cancers such as oral, breast, prostate, gastric and colorectal cancer [23][24][25][26][27][28][29][30][31]. These indicate that substitution in these SNPs may effect on genes' functions or expression levels.…”

Section: Introductionmentioning

confidence: 99%

Single Nucleotide Polymorphism (K589E) of the EXO1 Gene: Association with Colorectal Cancer Susceptibility and Clinicopathological Features

Aghdaei¹

2014

GHOA

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Background and aim: Exonuclease1 (EXO1) is a member of the RAD2 nuclease family which is involved in mismatch repair (MMR) system and contributes to the maintenance of genomic stability, modulation of DNA recombination and cell cycle arrest mediation. K589E (rs1047840) as a potentially functional polymorphism in EXO1 gene may alter cancer risk by influencing its repair activity. Method:We designed a case-control study consisting of 319 subjects with colorectal cancer (CRC) and 310 healthy controls to investigate the effect of K589E polymorphism on CRC susceptibility and clinicopathological features in an Iranian population. Genotype determination was performed by PCR-RFLP method. Results:We provided the first evidence that there is not any significant association between EXO1 K589E alleles and genotypes and risk of CRC, even after adjustment for sex, age and smoking status (OR=1.033; 95% CI 0.814-1.312). Also analysis of clinicopathological characteristics and genotype distribution did not show any significant correlation. Conclusion:Despite the well-known role of EXO1, our results revealed that EXO1 K589E polymorphism could not be a potential predisposing risk factor in genetic susceptibility to CRC, at least in the studied population. A large scale case-control study will need to be carried out to further validate this polymorphism as a noncontributor to the risk of CRC in Iranian population.

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Significant association of XRCC4 single nucleotide polymorphisms with prostate cancer susceptibility in Taiwanese males

Cited by 41 publications

References 14 publications

Role of DNA Repair-related Gene Polymorphisms in Susceptibility to Risk of Prostate Cancer

Role of DNA Repair-related Gene Polymorphisms in Susceptibility to Risk of Prostate Cancer

The DNA Repair Gene ERCC6 rs1917799 Polymorphism is Associated with Gastric Cancer Risk in Chinese

Single Nucleotide Polymorphism (K589E) of the EXO1 Gene: Association with Colorectal Cancer Susceptibility and Clinicopathological Features

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