Role of DNA Repair-related Gene Polymorphisms in Susceptibility to Risk of Prostate Cancer

Yang, Bo; Wen, Xiaofei; Liu, Hui; Liu, Feng

doi:10.7314/apjcp.2013.14.10.5839

Cited by 18 publications

(14 citation statements)

References 25 publications

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“…Wang et al found that rs751402 C>T was protective against breast cancer in Chinese Han women [47]. Additionally, the T allele of rs2296147 was associated with an increased risk of prostate cancer [35]. However, the results of previous studies have been inconsistent, possibly due to variations in the study populations and limited sample sizes.…”

Section: Discussionmentioning

confidence: 99%

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

et al. 2017

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Xeroderma pigmentosum group G (XPG) is a single-strand-specific DNA endonuclease that functions in the nucleotide excision repair pathway. Genetic variations in XPG gene can alter the DNA repair capacity of this enzyme. We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk. Forty-seven studies were identified in searches of the PubMed, Scopus, Web of Science, China National Knowledge Infrastructure, and WanFang databases. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model. We found that rs873601 G>A was associated with an increased overall cancer risk (AA vs. GG: OR = 1.14, 95% CI = 1.06–1.24; GA/AA vs. GG: OR = 1.08, 95% CI = 1.02–1.15; A vs. G: OR = 1.06, 95% CI = 1.02–1.10). In a stratified analysis, rs1047768 T>C was associated with an increased risk of lung cancer, rs2227869 G>C was associated with a decreased risk of cancer in population-based studies, and rs751402 C>T and rs873601 G>A were associated with the risk of gastric cancer. Our data indicate that rs873601 G>A is associated with cancer susceptibility.

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Section: Discussionmentioning

confidence: 99%

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

et al. 2017

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“…The relation of DNA repair gene polymorphism and cancer risk has been widely studies (Li et al, 2013;Yang et al, 2013). Previous studies concerning the association between ERCC4 rs1800067 A/G polymorphism and risk of cancer were controversial.…”

Section: Discussionmentioning

confidence: 99%

Associations of ERCC4 rs1800067 Polymorphism with Cancer Risk: an Updated Meta-analysis

Yuan

Liu²,

Xing³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In the present study, we selected eight potentially functional SNPs in four NER genes (e.g., XPC , XPD , XPF , and XPG ) to examine their associations with risk of PCa in a relatively large hospital-based case-control study of 1,004 PCa patients and 1,055 cancer-free controls of an Eastern Chinese Han population. Of these eight SNPs we selected, only rs2228001 and rs1318 have been studied in a previous Chinese study, in which the rs13181 G allele was found to be associated with a marginally increased risk of prostate cancer [28]. Other SNPs were not included in previously published pre-GWAS studies, nor in GWAS studies of Chinese populations or other populations.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Wang

et al. 2016

Oncotarget

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Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64–1.91, P = 0.003). Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities. These findings suggested that XPC SNPs may contribute to risk of PCa in Eastern Chinese men.

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Role of DNA Repair-related Gene Polymorphisms in Susceptibility to Risk of Prostate Cancer

Cited by 18 publications

References 25 publications

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

Associations of ERCC4 rs1800067 Polymorphism with Cancer Risk: an Updated Meta-analysis

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

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