Significance of Hematological Scoring System (HSS) in Early Diagnosis of Neonatal Sepsis

Narasimha, Aparna; Kumar, M. Sunil

doi:10.1007/s12288-010-0050-2

Cited by 55 publications

(66 citation statements)

References 8 publications

(9 reference statements)

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“…Elevated I:T ratio was found to be the most reliable indicator of sepsis in Makkar et al [18] study, and also in various other studies like those done by Ghosh et al [14] and Narasimha et al [22] Image 1: Band cell with toxic granulation (10x100)…”

Section: Performance Of Individual Haematological Findingsmentioning

confidence: 57%

“…SENSITIVITY (%) SPECIFICITY (%) Present study 38.0 62.5 Ghosh et al [14] 93 89 Narasimhaet al [22] 93.75 94.44…”

Section: Performance Of Individual Haematological Findingsmentioning

confidence: 78%

“…Total band forms: Ghosh et al [14] and Narasimha [22] et al reported that Immature PMN count is sensitive indicator of neonatal sepsis. In our study 78.9% of neonates with culture positive sepsis and 83.9% of neonates of the probable sepsis had elevated band cell counts.…”

Section: Performance Of Individual Haematological Findingsmentioning

confidence: 99%

“…2. I/T ratio: Ghosh et al [14] and Narasimha [22] et al reported that immature PMN count and I:T PMN ratio is sensitive indicator of neonatal sepsis.…”

Section: Performance Of Individual Haematological Findingsmentioning

confidence: 99%

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Role of Sepsis Screening in Early Diagnosis of Neonatal Sepsis

Bhardwaj¹

2018

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Section: Performance Of Individual Haematological Findingsmentioning

confidence: 57%

“…SENSITIVITY (%) SPECIFICITY (%) Present study 38.0 62.5 Ghosh et al [14] 93 89 Narasimhaet al [22] 93.75 94.44…”

Section: Performance Of Individual Haematological Findingsmentioning

confidence: 78%

Section: Performance Of Individual Haematological Findingsmentioning

confidence: 99%

“…2. I/T ratio: Ghosh et al [14] and Narasimha [22] et al reported that immature PMN count and I:T PMN ratio is sensitive indicator of neonatal sepsis.…”

Section: Performance Of Individual Haematological Findingsmentioning

confidence: 99%

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Role of Sepsis Screening in Early Diagnosis of Neonatal Sepsis

Bhardwaj¹

2018

jmscr

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“…Namun, deteksi adanya bakteriemia masih sulit karena waktu analisis mikrobiologi cukup lama (48-72 jam) dan tidak semua bakteri dapat diidentifikasi, di samping fasilitas kesehatan tidak menunjang. [8][9] Pemeriksaan rutin laboratorium hematologi bisa dilakukan hampir di setiap rumah sakit, sederhana, mudah dilakukan, biaya relatif murah, dan tidak membutuhkan waktu lama. Pemeriksaan hematologi dan sediaan hapus darah tepi dapat menggambarkan secara mikroskopik morfologi sel darah yang dapat digunakan untuk evaluasi diagnostik infeksi sistemik pada neonatus.…”

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Peran Sistem Skoring Hematologi dalam Diagnosis Awal Sepsis Neonatorum Awitan Dini

Adriani

Yantri

Mariko

2018

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*Departemen Ilmu Kesehatan Anak Fakultas kedokteran Universitas Andalas/RSUP dr. M. Djamil, Padang Latar belakang. Sepsis neonatorum awitan dini (SNAD) merupakan penyebab utama kesakitan dan kematian pada neonatus. Adanya gejala klinis yang tidak spesifik dan keterbatasan sarana pemeriksaan penunjang masih merupakan masalah dalam diagnosis sepsis. Sistem skoring hematologi (SSH) dapat digunakan sebagai metode deteksi awal SNAD. Tujuan. Mengetahui apakah sistem skoring hematologi (SSH) dapat digunakan dalam diagnosis awal SNAD. Metode. Penelitian ini merupakan penelitian cross sectional dan uji diagnostik pada bayi dengan risiko dan diduga sepsis neonatorum awitan dini yang dirawat di NICU/Perinatologi RSUP Dr. M Djamil Padang dari bulan Oktober 2016 hingga Juni 2017. Diagnosis sepsis ditegakkan berdasarkan pemeriksaan klinis dan biakan darah. Sistem skoring hematologi terdiri delapan parameter hematologis. Hasil. Subjek penelitian 78 pasien, terdiri dari tidak sepsis 30 orang (38%) sepsis klinis 28 orang (36%) dan terbukti sepsis 20 orang (26%). Nilai SSH tidak sepsis lebih rendah dari kelompok sepsis klinis dan terbukti sepsis. Tidak terdapat perbedaan yang bermakna nilai SSH kelompok terbukti sepsis dan sepsis klinis. Nilai SSH ≥2 memiliki nilai sensitifitas 100%, spesifitas 25,8 % dalam mendiagnosis sepsis (bakteremia ) pada bayi dengan dugaan SNAD. Kesimpulan. Sistem skoring hematologi ini dapat digunakan sebagai metode deteksi awal sepsis neonatorum awitan dini, terutama di rumah sakit dengan sarana pemeriksaan penunjang terbatas. Sari Pediatri 2018;20(1):17-23Kata kunci: sepsis neonatorum, sistem skoring hematologi, diagnosis awal The Role of A Hematology Scoring System in Early Onset Neonatal Sepsis DiagnosisRanti Adriani,* Eny Yantri,* Rinang Mariko* Background. Early onset neonatal sepsis (EONS) is a major cause of neonatal morbidity and mortality. Non-specific clinical symptoms and limited investigation facilities are some of the problems in the management of sepsis. The hematological scoring system can be used as an early detection tool for EONS. Objective. The purpose of the study is to evaluate whether a hematological scoring system can be useful in early diagnosis of EONS Method. This study is a cross-sectional study and diagnostic test in infants with risk and suspected EONS treated at NICU/Neonatology Department Perinatology Dr. M. Djamil Hospital in Padang, from October 2016 through June 2017. The diagnosis of sepsis is based on clinical examination and blood culture results. Results. Subjects were 78 patients, consisting of 30 (38%) as nonsepsis, 28 (36%) as clinical sepsis and 20 (26%)were proven to have sepsis. Hematologic scores in non-sepsis were lower compared to the clinical sepsis and proven sepsis groups. There were no significant differences in hematologic score of proven sepsis and clinical sepsis. The score of ≥2 on hematologic scoring system had 100% sensitivity, 25,8 % specificity for diagnosis of bacteremia in infants at risk and suspected EONS. Conclusion. This hematological scor...

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Platelet Indices and Their Kinetics Predict Mortality in Patients of Sepsis

Mangalesh¹,

Dudani

Malik

2021

Indian J Hematol Blood Transfus

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Platelet indices are inexpensive, easily accessible parameters and potentially useful prognostic indicators in sepsis. In this study we explore the differences in platelet indices and their kinetics between sepsis survivors and non-survivors. A retrospective cohort-study of 97 cases of culture-positive sepsis at a tertiary-care center in North India. Demographics, clinical and laboratory parameters at admission were assessed. Platelet count (PLT), mean-platelet-volume (MPV), platelet-distribution-width (PDW) and plateletcrit (PCT) on admission, and third, fifth and last days of hospitalization were analyzed. Fractional change in platelet indices (ΔMPV 72h, ΔPDW 72h , ΔPCT 72h , and ΔPLT 72h ) by day-3 were calculated. Unpaired and paired t-tests were used to compare survivors with non-survivors, and to study the change in platelet indices with time. Logistic regression was used for multivariate analysis. ROC-curves and optimum cut-offs to predict mortality were obtained. There were 64 survivors. Non-survivors had significantly higher ΔMPV 72h, ΔPDW 72h, day-1 MPV and PDW, and lower ΔPLT 72h . MPV and PDW increased, and PLT decreased with time among non-survivors. Trends were reversed in survivors. Only MPV and PDW showed significant change by day-3. Both were independent predictors of mortality on multivariate analysis, alongside ΔMPV 72h and ΔPLT 72h . On ROC analysis, MPV, PDW, ΔMPV 72h, ΔPDW 72h and ΔPLT 72h effectively predicted mortality. Cut-off for MPV was 10.25 fL (sensitivity = 93.9%, specificity = 60.9%), and PDW, 12.6% (sensitivity = 84.8%, specificity = 51.6%). A rise in MPV and a fall in PLT was associated with mortality in this study. MPV and PDW values at admission are effective predictors of mortality and may be used in conjunction with traditional parameters.

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Significance of Hematological Scoring System (HSS) in Early Diagnosis of Neonatal Sepsis

Cited by 55 publications

References 8 publications

Role of Sepsis Screening in Early Diagnosis of Neonatal Sepsis

Role of Sepsis Screening in Early Diagnosis of Neonatal Sepsis

Peran Sistem Skoring Hematologi dalam Diagnosis Awal Sepsis Neonatorum Awitan Dini

Platelet Indices and Their Kinetics Predict Mortality in Patients of Sepsis

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