AbstrakRumput fatimah (Anastatica Hierochuntica) mengandung senyawa fitokimia seperti alkaloid, tanin, dan flavonoid yang merupakan bagian fitoestrogen. Tujuan Penelitian ini adalah menganalisis pengaruh pemberian air rendaman rumput fatimah (Anastatica Hierochuntica) terhadap hormon oksitosin dan hormon prolaktin pada tikus putih (Rattus Norvegicus) menyusui. Jenis penelitian ini adalah eksperimental dengan desain post-tes only control group.Jumlah sampel 32 tikus menyusui yang dibagi menjadi 4 kelompok, yaitu kelompok kontrol dan 3 kelompok perlakukan P1, P2 dan P3 yang masing-masing diberi 10gr, 20gr dan 40gr rendaman Anastatica Hierochuntica. Penelitian dilakukan di Laboratorium Farmasi dan Biomedik Universitas Andalas. Hormon oksitosin dan hormon prolaktin diukur dengan mengunakan metode ELISA. Uji statistik menggunakan One Way Anova dan untuk mengetahui perbedaan pada kelompok digunakan uji Multiple Comparisons (post hoc test) jenis Bonferroni. Hasil penelitian ini menunjukkan terdapat perbedaan signifikan (p<0,05) kadar hormon oksitosin antara kelompok kontrol (56,604±10,907) dengan kelompok P2 (44,095±6,117). Pada hormon prolaktin juga berbeda secara bermakna (p<0,05) antara kelompok kontrol (11,794±1,633) dengan kelompok P3 (16,991±3,735). Terdapat perbedaan yang bermakna terhadap pemberian air rendaman rumput fatimah (Anastatica Hierochuntica) terhadap hormon oksitosin dan hormon prolaktin pada tikus putih (Rattus Norvegicus) menyusui. Kata kunci: rumput fatimah, oksitosin, prolaktin Abstract Fatimah grass (Anastatica Hierochuntica) contains phytochemical compounds such as alkaloids, tannins, and flavonoids which are part of phytoestrogens. The objective of this study was to analyze the effect of immersion of immature fatimah grass (Anastatica Hierochuntica) on the hormone oxytocin and prolactin hormone in breastfeeding albino rats (Rattus Norvegicus). This type of research was the experimental with post-tes only control group design.The samples of thirty-two mice were divided into four groups, namely control group and three treatment groups P1, P2, P3 each given 10gr, 20gr, and 40 gr immersion Anastatica Hierochuntica. The research was conducted at Andalas University's Pharmaceutical and Biomedical Laboratory. The hormone prolactin and oxytocin are measured by using ELISA method. Test Shapiro Wilk, to know the data normality continued One Way ANOVA and to know the difference in the group used the test Multiple Comparisons (pos hoc test) type Bonferroni. The results of this study showed a significant difference (p<0.05) of the hormone oxytocin level between the control groups (56.604 ± 10.907) with the P2 group (44.095 ± 6.117). The prolactin hormone also differed significantly (p<0.05) between the control group (11.7794 ± 1.633) with the P3 group (16.991 ± 3.735). There was a significant effect of immersion of fatimah grass (Anastatica Hierochuntica) to the oxytocin hormone and prolactin hormone in breastfeeding albino rats (Rattus Norvegicus).

*Departemen Ilmu Kesehatan Anak Fakultas kedokteran Universitas Andalas/RSUP dr. M. Djamil, Padang Latar belakang. Sepsis neonatorum awitan dini (SNAD) merupakan penyebab utama kesakitan dan kematian pada neonatus. Adanya gejala klinis yang tidak spesifik dan keterbatasan sarana pemeriksaan penunjang masih merupakan masalah dalam diagnosis sepsis. Sistem skoring hematologi (SSH) dapat digunakan sebagai metode deteksi awal SNAD. Tujuan. Mengetahui apakah sistem skoring hematologi (SSH) dapat digunakan dalam diagnosis awal SNAD. Metode. Penelitian ini merupakan penelitian cross sectional dan uji diagnostik pada bayi dengan risiko dan diduga sepsis neonatorum awitan dini yang dirawat di NICU/Perinatologi RSUP Dr. M Djamil Padang dari bulan Oktober 2016 hingga Juni 2017. Diagnosis sepsis ditegakkan berdasarkan pemeriksaan klinis dan biakan darah. Sistem skoring hematologi terdiri delapan parameter hematologis. Hasil. Subjek penelitian 78 pasien, terdiri dari tidak sepsis 30 orang (38%) sepsis klinis 28 orang (36%) dan terbukti sepsis 20 orang (26%). Nilai SSH tidak sepsis lebih rendah dari kelompok sepsis klinis dan terbukti sepsis. Tidak terdapat perbedaan yang bermakna nilai SSH kelompok terbukti sepsis dan sepsis klinis. Nilai SSH ≥2 memiliki nilai sensitifitas 100%, spesifitas 25,8 % dalam mendiagnosis sepsis (bakteremia ) pada bayi dengan dugaan SNAD. Kesimpulan. Sistem skoring hematologi ini dapat digunakan sebagai metode deteksi awal sepsis neonatorum awitan dini, terutama di rumah sakit dengan sarana pemeriksaan penunjang terbatas. Sari Pediatri 2018;20(1):17-23Kata kunci: sepsis neonatorum, sistem skoring hematologi, diagnosis awal The Role of A Hematology Scoring System in Early Onset Neonatal Sepsis DiagnosisRanti Adriani,* Eny Yantri,* Rinang Mariko* Background. Early onset neonatal sepsis (EONS) is a major cause of neonatal morbidity and mortality. Non-specific clinical symptoms and limited investigation facilities are some of the problems in the management of sepsis. The hematological scoring system can be used as an early detection tool for EONS. Objective. The purpose of the study is to evaluate whether a hematological scoring system can be useful in early diagnosis of EONS Method. This study is a cross-sectional study and diagnostic test in infants with risk and suspected EONS treated at NICU/Neonatology Department Perinatology Dr. M. Djamil Hospital in Padang, from October 2016 through June 2017. The diagnosis of sepsis is based on clinical examination and blood culture results. Results. Subjects were 78 patients, consisting of 30 (38%) as nonsepsis, 28 (36%) as clinical sepsis and 20 (26%)were proven to have sepsis. Hematologic scores in non-sepsis were lower compared to the clinical sepsis and proven sepsis groups. There were no significant differences in hematologic score of proven sepsis and clinical sepsis. The score of ≥2 on hematologic scoring system had 100% sensitivity, 25,8 % specificity for diagnosis of bacteremia in infants at risk and suspected EONS. Conclusion. This hematological scor...

AbstrakAda anyak penelitian yang membuktikan transfer kolesterol dari ibu ke janin melalui lapisan trofoblas yang membawa partikel LDL (Low Density Lipoprotein) dan HDL (High Density Lipoprotein). Pengambilan dan pemanfaatan LDL oleh plasenta merupakan mekanisme alternatif oleh janin untuk memperoleh asam lemak dan asam amino esensial. Tujuan penelitian ini untuk mengetahui hubungan kadar LDL dan HDL serum ibu hamil aterm dengan berat lahir bayi. Penelitian ini merupakan studi observasional dengan rancangan cross sectional. Dilakukan pemeriksaan kadar LDL dan HDL serum terhadap 31 sampel ibu hamil aterm yang dipilih secara consecutive sampling, kemudiaan saat bayi dari sampel lahir dilakukan penimbangan berat lahir bayi dalam 1 jam setelah lahir dengan keadaan tanpa pakaian. Data dianalisis menggunakan uji korelasi Pearson dilanjutkan dengan uji regresi linier sederhana, nilai p<0.05 dianggap bermakna secara statistik. Rerata kadar LDL serum ibu hamil aterm 138,52±37,86 mg/dl dengan 7 sampel (22,60%) kadar LDL <101 mg/dl. Rerata kadar HDL serum ibu hamil aterm 53,32±17,39 mg/dl dengan 13 sampel (41,90%) kadar HDL <48 mg/dl. Rerata berat lahir bayi 3150,00±489,89 gram dengan 2 sampel (6,50%) memiliki bayi dengan berat<2500 gram. Terdapat hubungan positif antara kadar LDL serum ibu hamil aterm dengan berat lahir bayi, kekuatan hubungan lemah (r=0,258), secara statistik tidak bermakna (p=0,161). Terdapat hubungan positif antara kadar HDL serum ibu hamil aterm, kekuatan hubungan sangat lemah (r=0,035), secara statistik tidak bermakna (p=0,850). Kesimpulan penelitian tidak terdapat hubungan kadar LDL dan HDL serum ibu hamil dengan berat lahir bayi. AbstractMany studies proved that the transferring of cholesterol from mother to fetus through the trophoblastic layer carried LDL (Low Density Lipoprotein) and HDL (High Density Lipoprotein) particles. Uptake and usage of LDL by placenta to the fetus is an alternative mechanism to obtain fatty acids and essential amino acids. The objective of this study was to determine whether there is a relationship between LDL and HDL serum level of pregnant women at term with infant birth weight. This study was an observational study with cross sectional design. Examination of LDL and HDL serum level to 31 term pregnancy sample choose by consecutive sampling, and then infant's birth weight was counted within 1 hour after birth without clothes. The data analyzed with Pearson correlation statistical test followed by simple linier regression statistical test. The mean of LDL serum level term pregnancy was 138,52±37,86mg/dlwith7 samples(22.60%) in LDL levels<101 mg/dl. The mean of HDL serum level at term pregnancy was 53,32±17,39 mg/dlwith 13 samples (41,90%) in HDL levels<48 mg/dl. The mean of infant birth weight was 3150,00±489,89 grams with 2 samples (6,50%) had infants weighing < 2500 grams. There is a positive relationship between LDL serum levels term pregnancy with birth weight infants, the strength of the relationship is weak (r =0,258), were not significant statistically (p=0...

Staphylococcal scalded skin syndrome (SSSS) describes a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus that originates from a focus of infection that may be a purulent conjunctivitis, otitis media, or occult nasopharyngeal infection. It usually begins with fever, irritability, and a generalized, paint, orange-red, macular erythema with cutaneous tenderness, and the rash progress from scarlatiniform to a blistering eruption in 24 to 48 hours. A diagnosis must distinguish SSSS from other skin diseases, such as toxic epidermal necrolysis, epidermolysis bullosa, bullous erythema multiforme, Streptococcal impetigo or listeriosis and thermal or chemical burns, all of which can manifest with similar symptoms. The prognosis of SSSS in children who are appropriately treated is good, with a mortality of less than 5%. A case was a three moths old boy hospitalized in Pediatric ward M. Djamil hospital with chief complain redness and peeling of the skin since 2 days before hospitalized. Culture of the skin, eyes and nose was Staphylococcus aureus, and patients was given ampicillin and gentamycin for seven days.

Staphylococcal scalded skin syndrome (SSSS) describes a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus that originates from a focus of infection that may be a purulent conjunctivitis, otitis media, or occult nasopharyngeal infection. It usually begins with fever, irritability, and a generalized, paint, orange-red, macular erythema with cutaneous tenderness, and the rash progress from scarlatiniform to a blistering eruption in 24 to 48 hours. A diagnosis must distinguish SSSS from other skin diseases, such as toxic epidermal necrolysis, epidermolysis bullosa, bullous erythema multiforme, Streptococcal impetigo or listeriosis and thermal or chemical burns, all of which can manifest with similar symptoms. The prognosis of SSSS in children who are appropriately treated is good, with a mortality of less than 5%. A case was a three moths old boy hospitalized in Pediatric ward M. Djamil hospital with chief complain redness and peeling of the skin since 2 days before hospitalized. Culture of the skin, eyes and nose was Staphylococcus aureus, and patients was given ampicillin and gentamycin for seven days.

Spontaneous Intestinal Perforation (SIP) terjadi pada 8,4 persen bayi dengan berat badan lahir sangat rendah. SIP ditandai dengan onset mendadak dan tidak ditemukannya tanda infeksi. Presentasi klinis SIP pada bayi bervariasi, dan etiologinya belum diketahui secara pasti. Konsekuensi klinis SIP dapat menimbulkan komplikasi yang cukup parah sehingga dokter harus menyadari kemungkinan penyebab dan gejala. Terapi utama SIP yaitu: drainase peritoneum dan laparotomi dengan reseksi. Dilaporkan kasus SIP pada by perempuan usia 2 hari, yang didiagnosis berdasarkan gejala klinis dan rontgen abdomen. Pasien dilakukan pemasangan drainase di abdomen dan mengamai perbaikan klinis.

AbstrakNutrisi ASI penting bagi pertumbuhan dan perkembangan bayi. Kesibukan pekerjaan menyebabkan ibu harus memerah dan menyimpan ASI untuk diberikan kepada bayi saat ibu jauh dari bayinya. Penelitian ini bertujuan mengetahui pengaruh suhu dan lama penyimpanan ASI terhadap kadar laktoferin dan lisozim yang terkandung di dalam ASI. Penelitian ini eksperimental murni dengan one group pretest-posttest design. Dilakukan di Puskesmas Seberang Padang, BPM Nurhaida, Klinik Meri Medika, BPM Rika Hardi dan laboratorium Pusat Diagnostik dan Riset Penyakit Infeksi Bagian Mikrobiologi Fakultas Kedokteran Universitas Andalas pada bulan Juni 2017 -Juli 2018. Sampel berjumlah 20 ASI ibu menyusui 4-10 hari postpartum. Kadar laktoferin dan lisozim diperiksa dengan ELISA. Uji normalitas data menggunakan Kolmogorov-smirnov. Uji bivariat menggunakan One-way Anova dan Kruskal-wallis. Uji multivariat menggunakan regresi linier berganda. Hasil penelitian menunjukkan terdapat perbedaan kadar laktoferin yang bermakna antara ASI segar, suhu 4⁰C dan -20⁰C (p=0,000), serta antara ASI Segar, penyimpanan 5 hari dan 28 hari (p=0,000). Terdapat perbedaan lisozim yang bermakna antara ASI segar, suhu 4⁰C dengan -20⁰C (p=0,000), serta antara ASI segar, penyimpanan 5 hari dan 28 hari (p=0,000). Uji multivariat menunjukkan lama penyimpanan berpengaruh lebih besar terhadap kadar laktoferin. Kesimpulan penelitian ini adalah kadar laktoferin ASI stabil dengan penyimpanan pada suhu -20°C selama 5 hari. Kadar lisozim ASI meningkat dengan penyimpanan pada suhu -20°C selama 5 hari. AbstractASI nutrition is important for baby's growth and development. Busy work causes the mother to be reddened and store breast milk to give to the baby when the mother is far from the baby. This study aims to determine the effect of temperature and duration of ASI storage on levels of lactoferrin and lysozyme contained in ASI. This research is pure experimental with one group pretest-posttest design. It was conducted at the Seberang Padang . The sample consisted of 20 breast milk mothers breastfeeding 4-10 days postpartum. Lactoferrin and lysozyme levels were examined by ELISA. Test the normality of the data using Kolmogorov-smirnov. Bivariate test using One-way Anova and Kruskal-wallis. Multivariate test uses multiple linear regression. The results showed that there were significant differences in lactoferrin levels between fresh breast milk, 4⁰C and -20⁰C (p = 0.000), and between Fresh ASI, storage 5 days and 28 days (p = 0.000). There was a significant difference in lysozyme between fresh breast milk, 4⁰C with -20⁰C (p = 0,000), and between fresh breast milk, storage 5 days and 28 days (p = 0,000). Multivariate tests show that storage time has a greater effect on lactoferrin levels. The conclusion of this study is that the levels of breast milk lactoferrin are stable with storage at -20°C for 5 days. ASI lysozyme levels increase with storage at -20° C for 5 days.

Spontaneous Intestinal Perforation (SIP) terjadi pada 8,4 persen bayi dengan berat badan lahir sangat rendah. SIP ditandai dengan onset mendadak dan tidak ditemukannya tanda infeksi. Presentasi klinis SIP pada bayi bervariasi, dan etiologinya belum diketahui secara pasti. Konsekuensi klinis SIP dapat menimbulkan komplikasi yang cukup parah sehingga dokter harus menyadari kemungkinan penyebab dan gejala. Terapi utama SIP yaitu: drainase peritoneum dan laparotomi dengan reseksi. Dilaporkan kasus SIP pada by perempuan usia 2 hari, yang didiagnosis berdasarkan gejala klinis dan rontgen abdomen. Pasien dilakukan pemasangan drainase di abdomen dan mengamai perbaikan klinis.