Signaling of hypochlorous acid by selective deprotection of dithiolane

Abstract

The selective signaling of hypochlorous acid by dithiane-protected [corrected] pyrene-aldehyde was investigated. Dithiolane derivative of pyrene-aldehyde was efficiently deprotected by hypochlorous acid to its corresponding aldehyde, which resulted in a prominent UV-vis and turn-on type fluorescence signaling. The signaling was not affected by the presence of other common alkali, alkaline earth metal ions, and anions. Interference from Hg(2+) ions could be successfully circumvented by using Chelex-100 resin. Dithiane [corrected] also provided selectivity toward hypochlorous acid over other commonly used oxidant of hydrogen peroxide.

Bioanalytical methods for hypochlorous acid detection: Recent advances and challenges

“…Due to the PET from Se to coumarin, CM1 showed fluorescence "OFF" in PBS buffer. In the presence of HOCl, the fluorescence of CM1 was switched "ON" within seconds, making it a good candidate for real-time By employing other fluorophores [105,123,[193][194][195][196][197][198][199][200], such as pyrene [87,88,201], phenanthroline [94,202], phenothiazine [100,[203][204][205], carbazole [93], NBD [206][207][208], MB [209], TPE [210], benzothiazole [211,212], phenanthroimidazole [96,213], and cyanine (Cy) [119,214]…”

Reversible and selective luminescent determination of ClO−/H2S redox cycle in vitro and in vivo based on a ruthenium trisbipyridyl probe

“…2) between the maximum luminescence intensity and the logarithmic concentration of [ClO À ] can be established for ClO À over the concentration range of 1 Â 10 À9 to 1 Â 10 À4 mol L À1 , which is much lower than that of other uorescence probe detection methods. [17][18][19][20][21][22][23] The regression equation was…”

A fluorescence ratiometric sensor for hypochlorite based on a novel dual-fluorophore response approach

“…Numerous fluorescence sensors for specific detection of OCl − have been reported [15][16][17][18][19][20][21][22][23][24][25]. However, most of the currently available OCl − sensors only utilized the changes in emission intensity as detecting signal.…”