A fluorescence ratiometric sensor for hypochlorite based on a novel dual-fluorophore response approach

Long, Lingliang; Zhang, Dongdong; Li, Xiufen; Zhang, Jinfang; Zhang, Chi; Zhou, Liping

doi:10.1016/j.aca.2013.03.016

Cited by 127 publications

(53 citation statements)

References 40 publications

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“…The resultant binding constant of the probe PTI with Al 3+ is 1.23 × 10 6 M −1 , obtained from the fluorescence titration (Figure S5, see Supporting Information) determined by non‐linear fitting analyses of the titration curves following the published reports . Detection limit has been well calculated from the linear relationship between PTI and Al 3+ as 45 nM (Figure S6, see Supporting Information). Job's plot reveals the 1:1 stoichiometric interactions between PTI and Al 3+ (Figure S7, see Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Highly Selective Optical and Fluorescence “Turn On” Signaling of Al³⁺: Cell Imaging and Estimation in Rice Plant

Saha

Sahoo

2019

ChemistrySelect

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A new pyrene based chemosensor (PTI) has been developed for selective estimation of toxic Al3+ ion in the root extract of rice plants (Oryza sativa) in neutral aqueous medium based on signaling through inhibition of intramolecular charge transfer (ICT) and initiation of chelation enhanced fluorescence (CHEF) mechanism. The rapid colorimertic and fluorimetric changes of the probe PTI upon interaction with Al3+ in the nanomolar scale has been well justified by different spectroscopic and theoretical analysis. The potentiality of the “turn on” signaling property of PTI also been demonstrated through cell imaging in the roots and stems of the rice plants efficiently.

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Section: Resultsmentioning

confidence: 99%

Highly Selective Optical and Fluorescence “Turn On” Signaling of Al³⁺: Cell Imaging and Estimation in Rice Plant

Saha

Sahoo

2019

ChemistrySelect

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“…To date, as we have just seen, there have been numerous fluorescence small-molecules that have been developedf or the detection of HOCl;m any famous fluorophores sucha s1 ,8naphthalimide, coumarin, BODIPY,c yanine, rhodamine, and fluorescein have been used to detect HOCl. [70][71][72][73][74][75][76][77][78][79][80] These fluorescent molecules are embedded with receptors such as the phenylc halcogenide group, the oxime group, spiro rings, etc. to help tune the reactivity of the fluorophore.…”

Section: Discussionmentioning

confidence: 99%

“…Zhou andc o-workers reported ar atiometric fluorescent sensorc ontaining at wo fluorophore unit (coumarin and rhodamine) connected directly to each other based on ad iacylhydrazine recognitiong roup (Scheme 61). [70] Initially,t he sensor Scheme57. Rhodamine based probe for the selective detection of HOCl.…”

Section: Sensors Based On Lactone/ring Openingmentioning

confidence: 99%

“…Zhou and co‐workers reported a ratiometric fluorescent sensor containing a two fluorophore unit (coumarin and rhodamine) connected directly to each other based on a diacylhydrazine recognition group (Scheme ) . Initially, the sensor shows an emission intensity of coumarin moiety at 501 nm; upon treatment with NaOCl, both fluorophores show their emission intensity at two different windows: coumarin at 464 nm and the rhodamine at 578 nm.…”

Section: Introductionmentioning

confidence: 99%

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Imaging of Hypochlorous Acid by Fluorescence and Applications in Biological Systems

Yudhistira

Mulay

Kim

et al. 2019

Chemistry An Asian Journal

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In recent decades, HOCl research has attracted a lot of scientists from around the world. This chemical species is well known as an important player in the biological systems of eukaryotic organisms including humans. In the human body, HOCl is produced by the myeloperoxidase enzyme from superoxide in very low concentrations (20 to 400 μm); this species is secreted by neutrophils and monocytes to help fight pathogens. However, in the condition called “oxidative stress”, HOCl has the capability to attack many important biomolecules such as amino acids, proteins, nucleotides, nucleic acids, carbohydrates, and lipids; these reactions could ultimately contribute to a number of diseases such as neurodegenerative diseases (AD, PD, and ALS), cardiovascular diseases, and diabetes. In this review, we discuss recent efforts by scientists to synthesize various fluorophores which are attached to receptors to detect HOCl such as: chalcogen‐based oxidation, oxidation of 4‐methoxyphenol, oxime/imine, lactone ring opening, and hydrazine. These synthetic molecules, involving rational synthetic pathways, allow us to chemoselectively target HOCl and to study the level of HOCl selectivity through emission responses. Virtually all the reports here deal with well‐defined and small synthetic molecular systems. A large number of published compounds have been reported over the past years; this growing field has given scientists new insights regarding the design of the chemosensors. Reversibility, for example is considered important from the stand point of chemosensor reuse within the biological system; facile regenerability using secondary analytes to obtain the initial probe is a very promising avenue. Another aspect which is also important is the energy of the emission wavelength of the sensor; near‐infrared (NIR) emission is favorable to prevent autofluorescence and harmful irradiation of tissue; thus, extended applicability of such sensors can be made to the mouse model or animal model to help image internal organs. In this review, we describe several well‐known types of receptors that are covalently attached to the fluorophore to detect HOCl. We also discuss the common fluorophores which are used by chemist to detect HOCl, Apart from the chemical aspects, we also discuss the capabilities of the compounds to detect HOCl in living cells as measured through confocal imaging. The growing insight from HOCl probing suggests that there is still much room for improvement regarding the available molecular designs, knowledge of interplay between analytes, biological applicability, biological targeting, and chemical switching, which can also serve to further sensor and theurapeutic agent development alike.

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“…Upon oxidation with hypochlorite, aldoxime gives the corresponding aldehyde [19][20][21]24], carboxylic acid [17], or nitrile oxide [18,23]. Many probes for detecting hypochlorite have been developed based on the mechanism of the oxidization-hydrolysis of hydrazide [39][40][41][42][43][44]. Inspired by the two strategies mentioned above, a novel probe for hypochlorite was designed by modifying the aldehyde with hydrazine group.…”

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confidence: 99%

A highly specific fluorescent probe for hypochlorite based on fluorescein derivative and its endogenous imaging in living cells

et al. 2015

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A fluorescence ratiometric sensor for hypochlorite based on a novel dual-fluorophore response approach

Cited by 127 publications

References 40 publications

Highly Selective Optical and Fluorescence “Turn On” Signaling of Al³⁺: Cell Imaging and Estimation in Rice Plant

Highly Selective Optical and Fluorescence “Turn On” Signaling of Al³⁺: Cell Imaging and Estimation in Rice Plant

Imaging of Hypochlorous Acid by Fluorescence and Applications in Biological Systems

A highly specific fluorescent probe for hypochlorite based on fluorescein derivative and its endogenous imaging in living cells

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A fluorescence ratiometric sensor for hypochlorite based on a novel dual-fluorophore response approach

Cited by 127 publications

References 40 publications

Highly Selective Optical and Fluorescence “Turn On” Signaling of Al3+: Cell Imaging and Estimation in Rice Plant

Highly Selective Optical and Fluorescence “Turn On” Signaling of Al3+: Cell Imaging and Estimation in Rice Plant

Imaging of Hypochlorous Acid by Fluorescence and Applications in Biological Systems

A highly specific fluorescent probe for hypochlorite based on fluorescein derivative and its endogenous imaging in living cells

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Highly Selective Optical and Fluorescence “Turn On” Signaling of Al³⁺: Cell Imaging and Estimation in Rice Plant

Highly Selective Optical and Fluorescence “Turn On” Signaling of Al³⁺: Cell Imaging and Estimation in Rice Plant