Short CommunicationPlatelet parameters in subjects infected with hookworm

Abstract

Hookworm is an important intestinal parasite infection with high prevalence in tropical countries. In addition to iron deficiency anaemia, the human hookworm appears to have evolved a number of complementary strategies to overcome the host's haemostatic processes. These include the inhibition of blood coagulation, platelet aggregation and mediator release, and the secretion of fibrinogenolytic enzymes. In this work, we studied the platelets in the subjects with detection of hookworm infection from screening stool examination comparing to those without. One hundred subjects were included, studied for stool parasite and platelet parameters. Of our 100 subjects, hookworms were identified in stools of six cases, giving an infection rate equal to 6%. The platelet parameters of the subjects showed a statistically significant lowering of mean platelet volume (MPV) in the subjects with hookworm infection. Also, we detected a non-significant lower platelet count in subjects with hookworm infections. Of interest, the alteration in platelet size, identified by platelet parameters, has never been documented in the literature. This observation might be a pathological process or might be an accidental finding in our study.

Respiratory syncytial virus infection is strongly correlated with decreased mean platelet volume

“…32 Increased MPVs are also seen with lower platelet counts in patients with Crimean-Congo hemorrhagic fever. 33 Decreases in MPV have also been associated with some infections, including sepsis, 34 hookworm, 35 and Trichinella. 36 Recently, we noticed that some patients with infection with respiratory syncytial virus (RSV) had relatively low MPVs.…”

Evaluation of Platelet Parameters in Patients With Pulmonary Hydatid Cyst

“…The increase in platelet volume in malaria may be caused by peripheral platelet destruction with early release of large immature platelets from the bone marrow. Wiwanitkit et al reported that a statistically significant decrease of MPV values was detected in the patients with hookworm infection 13. No significant difference in platelet count was found between the subjects with or without hookworm infection in the study.…”

Correlation between hematological parameters and ancylostomiasis: A retrospective study

“…Studies by Veraldi et al showed that neutrophils and lymphocytes were involved in the development of the ancylostome infection and that these cells were found in some tissue fluids . Wiwanitkit et al revealed that platelets were associated with ancylostomiasis. We observed elevated neutrophils and platelets and decreased lymphocytes in the patient group in comparison with the healthy controls.…”

“…Studies by Veraldi et al showed that neutrophils and lymphocytes were involved in the development of the ancylostome infection and that these cells were found in some tissue fluids [16][17][18]. Wiwanitkit et al19 revealed that platelets wereF I G U R E 1 Comparison of NLR (A), PLR (B), ELR (C) in ancylostomiasis patients and healthy controls. ELR, eosinophilto-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio associated with ancylostomiasis.…”