Respiratory syncytial virus infection is strongly correlated with decreased mean platelet volume

Renshaw, Andrew A.; Drago, Barbara; Toraya, Norma; Gould, Edwin W.

doi:10.1016/j.ijid.2013.01.012

Cited by 31 publications

(43 citation statements)

References 29 publications

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“…In another study of 58 cirrhotic patients with acute ascitic fluid infection also found that they had elevated MPV compared to non-infected patients [12]. However, in a study of 196 children with community-acquired pneumonia, a lower MPV was found compared to healthy controls [13], a finding later replicated in children with respiratory syncytial virus infection [14].…”

Section: Discussionmentioning

confidence: 98%

Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis

Cámara-Lemarroy

Delgado‐García

Cruz-Gonzalez

et al. 2017

J Infect Dev Ctries

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Introduction: Mean platelet volume (MPV) has been shown to reflect the inflammatory burden in different inflammatory and autoimmune diseases. Our objective was to analyze the MPV in patients with tuberculous (TBM) and bacterial meningitis (BM). Methodology: The demographic and clinical data of 73 consecutive patients that presented with either BM (n = 35) or TBM (n = 38) were retrospectively analyzed, as well as that of 28 age-and sex-matched controls. Results: MPV was 8.78 ± 1.58 fL in patients with BM and 6.42 ± 1.39 fL in the TBM group (p < 0.05). In the control group, MPV was 7.4 ± 0.66 fL, significantly higher and lower when compared with TBM and BM, respectively. MPV was significantly associated with diagnosis (adjusted OR: 5.15, 95% CI: 1.090-23.7; p = 0.03). With the optimal cut-off value of 7.62 fL, MPV had 82% sensibility and 78% specificity for the differential diagnosis of TBM versus BM. Lower platelet counts, higher serum creatinine, higher white blood cell counts, and higher blood-cerebrospinal fluid glucose ratio were also predictive of BM. Conclusions: Platelet counts were lower and MPV was higher in patients with BM compared to patients with TBM. Platelet indices, available in routine bloodwork, could be useful in the early differential diagnosis of these entities.

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Section: Discussionmentioning

confidence: 98%

Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis

Cámara-Lemarroy

Delgado‐García

Cruz-Gonzalez

et al. 2017

J Infect Dev Ctries

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“…In our study, MPV was found to be lower in the patients who had acute bronchiolitis compared to healthy children. Renshow et al (15) found MPV to be lower in patients hospitalized because of infection with respiratory sinsitial virus which is a common virus which causes to bronchiolitis compared to the control group. An increase in the number of young platelets and in MPV is expected with activation of platelets in case of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Reduction in mean platelet volume in children with acute bronchiolitis

et al. 2016

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Aim: Platelets which are known to play a role in inflamation change their shapes when they are activated and this change is reflected in mean platelet volume and platelet distribution width values. Therefore, the mean platelet volume and platelet distribution width values are considered to be beneficial parameters for the diagnosis and treatment of many inflammatory diseases. The aim of the study was to evaluate platelet volume indices in children with acute bronchiolitis. Material and Methods:A total of 514 infants who were below the age of 2 years old were evaluated in this study. Three hundred thirteen of these infants were diagnosed with acute bronchiolitis patients and 201 were healthy children. The patients were separated into four groups as mild, moderate, severe bronchiolitis and the control patient group. The groups were evaluated in terms of significant differences in the values of mean platelet volume and platelet distribution width. A p value of <0.05 was considered statistically significant for all results. Results:The mean platelet volume was found to be 6.8±0.6 fL in the patients with mild bronchiolitis attack, 6.7±0.6 fL in the patients with moderate bronchiolitis attack, 6.5±0.5 fL in the patients with severe bronchiolitis attack and 7.3±1.1 fL in the control group. The mean platalet volume was statistically significantly lower in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000). The platelet distribution width was found to be 17.2%±0.83 in the mild bronchiolitis attack group, 17.1%±0.96 in the moderate bronchiolitis attack group, 17.3%±0.87 in the severe bronchiolitis attack group and 16.9±1.6% in the control patient group. This difference was not statistically significant (p=0.159). The platelet count was statistically significantly higher in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000).

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“…In a previous study, some patients with respiratory syncytial virus (RSV) infections had relatively low MPVs. In a study that measured MPVs in a series of consecutive patients in various settings, RSV infections were found to have a strong correlation with a decrease in mean platelet volume [9]. Previous viral studies have supported the findings that MPV levels are elevated in some chronic viral diseases, such as chronic hepatitis B and C, whereas MPV levels decrease in some acute viral diseases, such as rotavirus gastroenteritis, HIV, and RSV.…”

Section: Introductionmentioning

confidence: 86%

“…Higher MPV levels were independently associated with high hospital mortality after admission to intensive care units [8]. There are many studies in which MPV values are investigated in viral infections [9,10,11,12,13,14,15,16]. In a previous study, some patients with respiratory syncytial virus (RSV) infections had relatively low MPVs.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of hematological parameters

Özyurt¹

2018

Ann Clin Anal Med

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Aim: Acute bacterial and viral infections are usually associated with elevations of the mean platelet volume. We correlated infection with influenza changes in mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), to determine whether these might be predictors for the duration of hospitalization or mortality. Material and Method: A total of 122 influenza patients (54 males and 68 females), including 87 children and 35 adults, and 42 age-gender-matched healthy individuals (18 males and 24 females) including 25 children and 17 adults were included in the study. Hematologic tests were conducted on the patients and controls. Linear regression analysis was used to determine independent predictors of hospitalization. Results: The MPV was significantly higher in influenza patients [10.7 (min/max 7.5-15) fL] than in the healthy control group [7.8(min/max 5.7-10.8)fL, p<0.001]. The NLR and PLR were similar in both groups. There was no correlation between MPV, NLR, or PLR and mortality. Predictors of hospitalization were determined to be neutrophil level (NL) and NLR and PLR ratios (p = 0.00, p = 0.035 and p = 0.041, respectively). Discussion: Neutrophil, MPV, NLR, and PLR were significantly higher in the influenza group. While the MPV was not determined to correlate with the length of stay and mortality in the patient group, the higher levels of NLR and PLR and increased neutrophil levels predicted the duration of hospitalization.

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Respiratory syncytial virus infection is strongly correlated with decreased mean platelet volume

Abstract: We conclude that infection with RSV is associated with decreased MPV and this may be clinically useful in children undergoing bronchoscopy.

Cited by 31 publications

References 29 publications

Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis

Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis

Reduction in mean platelet volume in children with acute bronchiolitis

Prognostic value of hematological parameters

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