Correlation between hematological parameters and ancylostomiasis: A retrospective study

Abstract

Objective Our aim intended to determine the relationship between hematological parameters (neutrophil‐to‐lymphocyte ratio [NLR], platelet‐to‐lymphocyte ratio [PLR], and eosinophil‐to‐lymphocyte ratio [ELR]) and ancylostomiasis. Methods There were 140 patients with ancylostomiasis and 159 healthy controls enrolled in this study. All data were collected from electronic medical records of the First Affiliated Hospital of Guangxi Medical University. Results The levels of NLR, PLR, and ELR in ancylostomiasis patients were significantly higher than those in the healthy controls (all P = 0.000). A receiver operating characteristic curve was generated to assess the diagnostic efficacy of these three hematological parameters. ELR (AUC = 0.850; sensitivity = 75.00%; specificity = 86.80%) showed the superior AUC than those of NLR (AUC = 0.718; sensitivity = 53.57%; specificity = 88.68%) and PLR (AUC = 0.806; sensitivity = 68.57%; specificity = 86.79%), respectively. A multivariate regression model using the two selected indices (RBC and ELR) was established with the model's sensitivity and specificity reached 82.86% and 96.23%, respectively. In the ancylostomiasis patient group, NLR (r = −0.452, P = 0.000) and PLR (r = −0.357, P = 0.000) were reversely associated with eosinophils. Conclusion The pretreatment levels of the three hematological parameters (NLR, PLR, and ELR) may serve as valuable indicators for distinguishing patients with ancylostomiasis from healthy controls. NLR and PLR are negatively associated with the previous indicator, eosinophils.

The relationship between food quality score with inflammatory biomarkers, and antioxidant capacity in young women

“…There is growing evidence that systemic inflammatory responses can be evaluated by hematological parameters that are easily measured in the clinic; for example white blood cells (WBC), neutrophils, red blood cell distribution width (RDW), mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and RDW/platelet ratio (RPR; Fu et al, 2015 ; Hu et al, 2013 ; Yang et al, 2017 ). The predictive or prognostic value of these parameters has been studied in a variety of conditions such as cancers (Wang et al, 2017 ; Bao et al, 2018 ), CVDs (Kamińska et al, 2018 ), autoimmune (Yang et al, 2015 ), and parasitic diseases (Hu et al, 2019 ).…”