Sexual risk behavior in women with cervical human papillomavirus infection

Sikström, Bo; Hellberg, Dan; Nilsson, Staffan; Brihmer, Christina; Mårdh, Per‐Anders

doi:10.1007/bf02437579

Cited by 10 publications

(14 citation statements)

References 33 publications

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“…7,9,19,22,25 Our study confirmed that history of genital infection is an increased risk of developing cervical cancer. In parallel to our study's results, there are some case-control studies that reported positive associations between history of genital infection and cervical cancer.…”

supporting

confidence: 79%

“…14,18 According to our study results, non-use of alcohol had a decreased risk for cervical cancer, the OR being 0.30, which was parallel with other study results. 19,20,21 Sikstrom et al 22 reported that smoking, alcohol and drug abuse are risk markers for cervical human papillomavirus infection. However, there are some studies that could not find such a relationship.…”

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confidence: 99%

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Risk Factors for Cervical Cancer: Results from a Hospital-Based Case-Control Study

Reis¹,

Beji²,

Kılıç³

2011

UHOD

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The aim of this study was to investigate risk factors for cervical cancer in Turkish women. In a hospital-based case-control study in ‹stanbul, 209 patients with histologically confirmed cervical cancer were compared with 1050 controls, who were admitted to the different departments of the same hospital. Odds ratios (OR) and 95% confidence intervals (CI) were obtained from multivariate logistic regression analysis, fitted by the method of maximum likelihood. Risk factors for cervical cancer were found to be early age at first sexual intercourse (OR = 58.07, 95% CI: 27.88-120.95) and history of genital infection (OR = 5.17, 95% CI: 3.51-7.60). However, compared with controls, it was found that cases including higher education (OR = 0.18, 95% CI: 0.10-0.30), non-married (OR = 0.07, 95% CI: 0.04-0.12) and non-use of alcohol (OR = 0.30, 95% CI: 0.14-0.65) had a decreased risk for cervical cancer. Our results are supportive of the hypothesis that early age at first sexual intercourse and history of genital infection is related with the risk factors for cervical cancer. Therefore, monogamy, late commencement of sexual activity, personal hygiene and use of barrier contraceptive methods help towards primary prevention. Keywords: Cervical cancer, Risk factors ABSTRACT Servikal Kanser ‹çin Risk Faktörleri: Hastane Temelli Vaka-Kontrol Çal›flmas›n›n Sonuçlar›Bu araflt›rman›n amac›, Türk kad›nlar›'ndaki servikal kanser risk faktörlerini belirlemektir. ‹stanbul'da yürütülen hastane temelli vaka-kontrol çal›flmas›nda, histolojik olarak servikal kanser tan›s› konulmufl 209 hasta, ayn› hastanenin farkl› bölümlerine baflvuran 1050 kontrol grubuyla karfl›laflt›r›ld›. Göreli risk oranlar› (ORs) ve %95 güven aral›¤› (CI), maksimum benzerlik metoduyla uygunlu¤u sa¤lanan, çok de¤iflkenli lojistik regression analizinden elde edildi. Servikal kanser için risk faktörleri, erken yafllarda ilk cinsel iliflki (OR = 58.07, 95% CI: 27.88-120.95) ve genital infeksiyon öyküsü (OR = 5.17, 95% CI: 3.51-7.60) olarak bulundu. Buna ragmen kontrol grubuyla karfl›laflt›r›ld›¤›nda, yüksek e¤itim (OR = 0.18, 95% CI: 0.10-0.30), evli olmama (OR = 0.07, 95% CI: 0.04-0.12) ve sigara kullanmama (OR = 0.30, 95% CI: 0.14-0.65), servikal kanser için azalt›c› risk faktörü olarak belirlendi. Araflt›rma sonucu, erken yaflta ilk cinsel iliflkinin ve genital infeksiyon öyküsünün servikal kanser için risk faktörü oldu¤unu göstermektedir. Bu nedenle primer korunmada tek efllilik, seksüel aktivitenin uygun yaflta bafllat›lmas› ve bariyerli kontraseptif yöntem kullan›m› önemlidir. Anahtar Kelimeler: Serviks kanseri, Risk faktörleriULUSLARARASı HEMATOLOJI-ONKOLOJI DERGISI ARTICLE

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confidence: 79%

mentioning

confidence: 99%

Risk Factors for Cervical Cancer: Results from a Hospital-Based Case-Control Study

Reis¹,

Beji²,

Kılıç³

2011

UHOD

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“…14,15,[32][33][34][35] Other risk behaviors that have been associated with HPV infection include smoking and alcohol use. 14,15 Black race has also been associated with HPV infection.…”

Section: Discussionmentioning

confidence: 99%

“…After the Pap smear, exfoliated cervicovaginal cells were obtained by lavage for HPV determination. 28 Samples were tested by polymerase chain reaction for the following HPV types: 2,6,11,13,16,18,26,[31][32][33][34][35]39,40,42,45,[51][52][53][54][55][56][57][58][59] 61, 62, 64,[66][67][68][69][70] 72, 73 (PAP238A), 81 (AE7), 82 (W13B), 83 (PAP291), 85 (PAP155), AE2, AE6, and AE8. Samples were tested by Southern blot hybridization using 32 P-labeled HPV DNA types 11, 16, 18, 51, 52, and 53.…”

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Mediators of the Association Between Age of First Sexual Intercourse and Subsequent Human Papillomavirus Infection

et al. 2002

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ABSTRACT.Objective. Previous studies have demonstrated that early age of first sexual intercourse is associated with human papillomavirus (HPV) infection. The objective of this study was to identify a set of risk behaviors and partner characteristics that mediate the association between age of first sexual intercourse and subsequent HPV infection in adolescent and young adult women.Methods. Female university students completed surveys and underwent HPV testing every 6 months for up to 3 years. HPV-positive participants were matched to HPV-negative participants (252 pairs, total N ‫؍‬ 504). Associations were examined between risk behaviors/partner characteristics and both age of first sexual intercourse and HPV infection. Those variables associated with either age of first sexual intercourse or HPV infection were entered into a generalized estimating equation (to account for the matched study design) modeling the association between age of first sexual intercourse and HPV infection.Results. Mean age of first sexual intercourse was 16.7 (؎1.8) years, and early age of first sexual intercourse was associated significantly with HPV infection (␤ ‫؍‬ ؊0.20; odds ratio: 0.82; 95% confidence interval: 0.74 -0.90). The association was mediated by number of sexual partners in the past 6 months, history of sexually transmitted infection, alcohol and drug use related to sexual behaviors, and partner's number of sexual partners.Conclusion. A set of behavioral risk factors and partner characteristics partially mediate the association between age of first sexual intercourse and subsequent HPV infection. Pediatrics 2002;109(1). URL: http://www. pediatrics.org/cgi/content/full/109/1/e5; human papillomavirus, sexual intercourse, adolescent, risk behaviors, mediator.ABBREVIATIONS. HPV, human papillomavirus; STI, sexually transmitted infection; GEE, generalized estimating equation. G enital human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in the United States, with a prevalence of approximately 50% in sexually active adolescent and young adult women. 1,2 Infection with certain HPV types, particularly types 6 and 11, is associated with the development of anogenital warts, which has a prevalence of approximately 2% in sexually active men and women. 3 HPV infection with high-risk oncogenic types, such as 16, 18, 31, and 45, may progress from infection to cervical dysplasia, carcinoma in situ, and invasive cervical cancer. 4 -8 Although HPV infection is frequently transient in adolescent and young adult women and the natural history of HPV infection and cytologic abnormalities is still being defined, 9 this population has a relatively high incidence of abnormal Papanicolaou (Pap) smears. Mount and Papillo 10 reported that the incidence of Pap smears with squamous intraepithelial lesion was higher in adolescents 10 to 19 years of age than in adult women, and other investigators 11,12 have proposed that the prevalence of abnormal Pap smears and cervical dysplasia is increasing worldwide in y...

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Smoking, alcohol, sexual behaviour and drug use in women with cervical human papillomavirus infection

Sikström

Hellberg

Nilsson

et al. 1995

Arch Gynecol Obstet

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Sexual risk behavior in women with cervical human papillomavirus infection

Cited by 10 publications

References 33 publications

Risk Factors for Cervical Cancer: Results from a Hospital-Based Case-Control Study

Risk Factors for Cervical Cancer: Results from a Hospital-Based Case-Control Study

Mediators of the Association Between Age of First Sexual Intercourse and Subsequent Human Papillomavirus Infection

Smoking, alcohol, sexual behaviour and drug use in women with cervical human papillomavirus infection

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