Smoking, alcohol, sexual behaviour and drug use in women with cervical human papillomavirus infection

Sikström, Bo; Hellberg, Dan; Nilsson, Staffan; Mårdh, Per‐Anders

doi:10.1007/bf01314641

Cited by 11 publications

(3 citation statements)

References 26 publications

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“…Conversely, two studies found no relationship between alcohol intake and HPV endpoints. A cross-sectional analysis of women seeking contraceptive advice in three Swedish clinics reported that recent use of alcohol was not associated with cervical HPV infection after adjustment for sexual/behavioral factors (25). In a separate study among high-risk HPV-positive women, alcohol intake was not associated with risk of high-grade squamous intraepithelial lesions (26).…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and prevalence of human papillomavirus (HPV) infection among US men in the HPV in Men (HIM) study

et al. 2014

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Objectives Moderate alcohol consumption can impair host defense against viral infections. The objective of this cross-sectional analysis was to assess the association between alcohol intake and prevalent HPV infection among U.S. men enrolled in the HIM (HPV in Men) Study utilizing quantitative alcohol intake measured from a food frequency questionnaire. Methods The HIM study is a prospective, multinational study of the natural history of HPV infection. For this report we restricted our analyses to men from the US cohort (No. = 1,313). Samples from the corona of glans penis, penile shaft, and scrotum were combined for HPV DNA testing. Self-reported alcohol intake was quantified by grams of alcohol intake per day. Multivariable prevalence ratios (mPR) were used to assess the association between alcohol intake and HPV infections. Results Prevalent infections were significantly higher among men in the highest quartile of alcohol intake and multivariable models revealed that the highest quartile of alcohol intake was associated with significantly increased risks for any- (mPR=1.13; 95% CI 1.00–1.27) and oncogenic (mPR=1.35; 95% CI 1.08–1.68) HPV types. The fourth quartile of alcohol intake was associated with elevated risks for prevalent HPV infection across all strata of number of sexual partners and among never- and current smokers, but not among former smokers. Conclusions These results demonstrate that high intake of alcohol is associated with an increased risk for prevalent HPV infections among men. The biological role that alcohol plays in genital HPV infection remains understudied and limited epidemiologic data exist especially among men.

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Section: Discussionmentioning

confidence: 99%

Alcohol consumption and prevalence of human papillomavirus (HPV) infection among US men in the HPV in Men (HIM) study

et al. 2014

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“…However, the literature data regarding the potential relationship between alcohol consumption and HPV infection are conflicting. A previous study showed that there is a positive relationship between alcohol and HPV infection [39], while a recent one showed no relationship [40]. On the contrary, HPV infection declined with increasing age.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HPV infection among Greek women attending a gynecological outpatient clinic

et al. 2010

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BackgroundHuman papillomavirus (HPV) infection is a causative factor for cervical cancer. Early detection of high risk HPV types might help to identify women at high risk of cervical cancer. The aim of the present study was to examine the HPV prevalence and distribution in cervical smears in a sample of Greek women attending a gynecological outpatient clinic and to explore the determinants of the infection.MethodsA total of 225 women were studied. All women underwent a regular gynecological control. 35 HPV types were studied; 6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 43, 44, 45, 51, 52, 53, 54, 56, 58, 59, 61, 62, 66, 68, 70, 71, 72, 73, 81, 82, 83, 84, 85 and 89. Also, basic demographic information, sociodemographic characteristics and sexual behavior were recorded.ResultsHPV was detected in 22.7% of the study population. The percentage of the newly diagnosed women with HPV infection was 17.3%. HPV-16 was the most common type detected (5.3%) followed by HPV-53 (4.9%). 66.2% of the study participants had a Pap test during the last year without any abnormalities. HPV infection was related positively with alcohol consumption (OR: 2.19, 95% CI: 1.04-4.63, P = 0.04) and number of sexual partners (OR: 2.16, 95% CI: 1.44-3.25, P < 0.001), and negatively with age (OR: 0.93, 95% CI: 0.87-0.99, P = 0.03), and monthly income (OR: 0.63, 95% CI: 0.44-0.89, P = 0.01).ConclusionThe prevalence of HPV in women attending an outpatient clinic is high. Number of sexual partners and alcohol consumption were the most significant risk factors for HPV infection, followed by young age and lower income.

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“…Factors which influence risk for cervical cancer such as infection with HPV, smoking, multi parity, oral contraceptives usage, early onset of sexual intercourse and multiple sexual partners may very well be confounders in the current study. [44][45][46][47][48] Incorporating these socio-demographic factors will thereby also justify an increase in the sample size but overcoming these limitations in future studies may greatly improve the results, potentially providing more clarity in identifying SNP-malignancy associations.…”

Section: Discussionmentioning

confidence: 99%

Fas promoter -670 polymorphism and the risk of cervical cancer: A case-control study in multi-ethnic Malaysia

Tan

Husain

Sidik

et al. 2018

JER

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Background/Objective: Single nucleotide polymorphism (SNP) is a commonly occurring DNA sequence variation within the human population. The prevalence of these sequence variations differs in various populations and may lead to the suboptimal regulation of genes, including those of the apoptosis pathway. The regulation of cellular death is partially controlled by the interaction between tumor necrosis factor receptor family gene, Fas and its ligand, FasL. A base substitution in Fas -670 A>G (rs1800682) has been found to alter the binding affinity of the Fas protein to its activators, potentially altering its apoptotic potential. The lack of proper apoptosis regulation can lead to a wide plethora of human conditions involving uncontrolled cellular growth such as cancer. The purpose of the study was to investigate whether there was any association between the Fas -670 polymorphism and risk of cervical cancer in multi-ethnic Malaysian women.Methods: Using restriction fragment length polymorphism (RFLP-PCR), Chi-square and logistic regression analysis, this study investigated the Fas -670 SNP and its associations with cervical cancer in the multi-ethnic population of Malaysia.Results: No significant associations were found between Fas -670 A>G SNP and risk of cervical cancer using the genotype model, dominant model and allele frequency model analysis, even after stratification into the Malay, Chinese and Indian ethnic subgroups; and cancer types.Conclusions: Our results showed that the A>G SNP of Fas -670 does not affect the risk of cervical carcinogenesis in Malaysian females.

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Smoking, alcohol, sexual behaviour and drug use in women with cervical human papillomavirus infection

Abstract: The results of this study indicate that smoking, alcohol and drug abuse are risk markers, but not causal factors, for CHPI.

Cited by 11 publications

References 26 publications

Alcohol consumption and prevalence of human papillomavirus (HPV) infection among US men in the HPV in Men (HIM) study

Alcohol consumption and prevalence of human papillomavirus (HPV) infection among US men in the HPV in Men (HIM) study

Prevalence of HPV infection among Greek women attending a gynecological outpatient clinic

Fas promoter -670 polymorphism and the risk of cervical cancer: A case-control study in multi-ethnic Malaysia

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