Serum proteins, blood and plasma volumes in experimentalTrypanosoma vivax infections of sheep and goats

Abstract

Measurements of blood and plasma volumes using 131I-albumin, and of red cell volume using 51Cr in goats and sheep infected with Trypanosoma vivax for 1 to 2 months (at which time the anaemia was severe) showed statistically significant increases in blood volume (29 per cent and 57 per cent) and plasma volume (44 per cent and 59 per cent), and decreases in red cell volume per kilogram body weight (49 per cent and 50 per cent) in goats and sheep respectively. Total serum proteins and gamma globulins increased, while serum albumin decreased, in T. vivax infected sheep and goats. These findings indicate that the anaemia manifested, with mean packed cell volume decreased by 60 per cent and 47 per cent in goats and sheep respectively at the time of red cell volume measurements, is attributable partly to haemodilution and partly to an actual decrease in total volume oc circulating red blood cells.

The Trypanosoma brucei gambiense Secretome Impairs Lipopolysaccharide-Induced Maturation, Cytokine Production, and Allostimulatory Capacity of Dendritic Cells

“…lism, protein synthesis, signaling, and cell cycle and cell organization. Moreover, the secretome appeared to be unexpectedly rich in various peptidases covering more than 10 peptidase families or subfamilies, among which some could play a role in pathology (52)(53)(54). Even though the functions of the secretome identified are not involved in parasite physiology, previous evidence exists for their potential involvement in mechanisms of enslavement of the host.…”

Influence of an experimental Trypanosoma congolense infection and plane of nutrition on milk production and some biochemical parameters in West African Dwarf goats

“…An increase of serum total protein mainly due to the increase of the gamma globulin fraction was also reported by Van Dam (1996) in West African Dwarf goats and this was linked to the initiation of the immune response. The decline in albumin could also be due to the initiation of the immune response and synthesis of immunoglobulins as well as to a probable haemodilution (Katunguka-Rwakishaya et al, 1992;Anosa and Isoun, 1976). A significantly lower level of albumin has also been reported in T. evansi-infected camels whilst no alterations of urea and total protein concentration were noticed (Chaudhary and Iqbal, 2000).…”

Host-Parasite Interactions in Trypanosomiasis: on the Way to an Antidisease Strategy

“…Thus, OPs are strongly thought to be responsible for the observed endocrine dysfunctions following parasite lysis (144) and more precisely, for the reduction in plasma levels of atrial natriuretic factor (107). This reduction would explain the reported hypervolemia (3,155), and thereby the cardiomyopathy, known to occur in early AT (19). In vivo treatments with OP inhibitors have been shown to improve the survival rate during T. brucei brucei infection.…”