Measurements of blood and plasma volumes using 131I-albumin, and of red cell volume using 51Cr in goats and sheep infected with Trypanosoma vivax for 1 to 2 months (at which time the anaemia was severe) showed statistically significant increases in blood volume (29 per cent and 57 per cent) and plasma volume (44 per cent and 59 per cent), and decreases in red cell volume per kilogram body weight (49 per cent and 50 per cent) in goats and sheep respectively. Total serum proteins and gamma globulins increased, while serum albumin decreased, in T. vivax infected sheep and goats. These findings indicate that the anaemia manifested, with mean packed cell volume decreased by 60 per cent and 47 per cent in goats and sheep respectively at the time of red cell volume measurements, is attributable partly to haemodilution and partly to an actual decrease in total volume oc circulating red blood cells.

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SummaryWild-caught shrews (Urocidura sp.), the only known wildlife host of the rabiesrelated agent Mokola virus, were given various dose levels of Mokola virus by different routes (subcutaneous, intramuscular, and oral), and then were examined for recovery of virus, presence of histopathologic lesions, and ability to transmit virus by bite to laboratory mice. Thirteen shrews, given virus by each of the routes, showed evidence of having become infected. Eleven of these became ill and yielded virus from multiple tissues, in which lesions were observed. Of the two infected shrews that remained asymptomatic, both showed histopathologic lesions and one also yielded virus, while the other was virus-negative (only brain was tested) but transmitted virus to a mouse. Four of the shrews that were virus-positive also transmitted the virus to mice. Thirty other inoculated shrews, as well as control shrews, did not yield virus and failed either to show lesions compatible with Mokola virus infection or to transmit virus.

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