Serum prolidase enzyme activity in obese subjects and its relationship with oxidative stress markers

Aslan, Mehmet; Düzenli, Ufuk; Esen, Ramazan; Soyoral, Yasemin Usul

doi:10.1016/j.cca.2017.08.039

Cited by 17 publications

(10 citation statements)

References 35 publications

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“…They reported that serum prolidase enzyme activity and oxidative stress were both significantly higher in Behçet’s disease patients. In another study, increased serum prolidase activity and decreased antioxidant levels were closely associated with increased oxidative stress levels in obese patients [12]. Similar to other studies, in our article, prolidase activities in AA patients were higher than in the healthy control group.…”

Section: Discussionsupporting

confidence: 79%

Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata

Dizen-Namdar

Koçak

Kıdır³

et al. 2018

Skin Pharmacol Physiol

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Background: Alopecia areata (AA) is a disease characterized by the hair loss sharply limited in any part of the body, especially on the scalp, in circular or oval areas. The purpose of this study is to search the serum paraoxonase 1 (PON1), arylesterase and oxidative status with serum prolidase activities in people with AA. Methods: The study included 60 AA and 50 healthy control subjects. In both groups, serum PON1, prolidase, arylesterase activities, total oxidative status (TOS) and total antioxidant capacity (TAS) levels and oxidative stress index (OSI) were calculated. Results: TOS, OSI levels and prolidase activity in patients with AA were found to be significantly higher compared to the control group (p = 0.02, p = 0.004, p < 0.001, respectively), whereas PON1 and arylesterase activities were significantly lower (p < 0.001, p = 0.005, respectively). There was no difference in serum TAS levels between the two groups. Conclusion: This comprehensive work shows that the role of oxidative stress is very important in the pathogenesis of AA. In this study, we believe that we clarified the pathogenesis of oxidative stress for AA patients by investigating the TAS, TOS, OSI levels, PON1, arylesterase and prolidase enzyme activity parameters.

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Section: Discussionsupporting

confidence: 79%

Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata

Dizen-Namdar

Koçak

Kıdır³

et al. 2018

Skin Pharmacol Physiol

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“…Post-translational modifications of prolidase have been shown to regulate its enzymatic abilities and in humans, deficiency in prolidase can cause a range of chronic, debilitating health conditions (Viglio et al, 2006;Kitchener et al, 2012). Increased serum proloidase activity has also been associated with oxidative stress in humans in relation to obesity (Aslan et al, 2017). Increased levels of prolidase activity are associated to some cancers, leading to the development of proline prodrugs (Mittal et al, 2005).…”

Section: -3-3 Protein Epsilon Isoform X1mentioning

confidence: 99%

Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca

Magnadóttir

Uysal-Onganer

Kraev

et al. 2020

Comparative Biochemistry and Physiology Part D: Genomics and Pr

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“…Aslan et al 28 showed that while the serum TAC levels were low in obese patients, serum TOS and prolidase activity were high. So they commented that increased serum prolidase activity and decreased antioxidant levels seem to be a result of increased of oxidative stres levels in obese patients.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress And Prolidase Enzyme Activity In The Pathogenesis Of Primary Varicose Veins

et al. 2017

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Objectives Vascular endothelial dysfunction leads to the emerging of free oxygen radicals, deficiency of antioxidant system, forming of oxidative stress, inflammatory processes and release of proinflammatory cytokines. These things play big role in the development of primary varicose veins. Prolidase has been reported as an indicator of oxidative stress in diabetes, diabetic neuropathy, non-ulcerous dyspepsia, osteoporosis, polycystic over syndrome and many other diseases. The aim of this study is to evaluate the oxidative stress at venous insufficiency and to provide preliminary knowledge about the role of prolidase enzyme in varicose vein formation. Methods Ninety patients aged between 22 and 80 (47.35 ± 17.69) were included in the study and divided into 3 groups. Group1(n:30)(Serum control group): Patients without venous insufficiency. Group 2(n:30)(Tissue control group(healthy vein group): Patients underwent coronary artery bypass surgery (the remaining portion of great saphenous vein used as coronary artery bypass graft used as normal tissue) . Group 3(n:30)(Varicose vein group): Patients underwent varicose vein surgery (varicose vein and serum of these patients were used for study). Total Oxidant Status (TOS), Total Antioxidant Status (TAS), Oxidative Stress Index (OSI) and Prolidase enzyme levels were detected in tissue and serum samples. Results No significant changes were detected between three groups' serum samples in oxidative stress parameters and in the prolidase enzyme activity. The tissue TOS and OSI were higher in varicose vein group according to normal vein group and this was found statistically significant. And TAC levels in varicose vein group were significantly lower than normal vein group. Prolidase enzyme activity in varicose vein group was found higher according to normal vein group. Conclusion Oxidative stress plays a role at the development of primary varicose veins at biochemical level. Prolidase enzyme related with oxidative stress may play an important role in the pathogenesis of primary varicose veins.

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Serum prolidase enzyme activity in obese subjects and its relationship with oxidative stress markers

Cited by 17 publications

References 35 publications

Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata

Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata

Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca

Oxidative Stress And Prolidase Enzyme Activity In The Pathogenesis Of Primary Varicose Veins

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