Background: Alopecia areata (AA) is a disease characterized by the hair loss sharply limited in any part of the body, especially on the scalp, in circular or oval areas. The purpose of this study is to search the serum paraoxonase 1 (PON1), arylesterase and oxidative status with serum prolidase activities in people with AA. Methods: The study included 60 AA and 50 healthy control subjects. In both groups, serum PON1, prolidase, arylesterase activities, total oxidative status (TOS) and total antioxidant capacity (TAS) levels and oxidative stress index (OSI) were calculated. Results: TOS, OSI levels and prolidase activity in patients with AA were found to be significantly higher compared to the control group (p = 0.02, p = 0.004, p < 0.001, respectively), whereas PON1 and arylesterase activities were significantly lower (p < 0.001, p = 0.005, respectively). There was no difference in serum TAS levels between the two groups. Conclusion: This comprehensive work shows that the role of oxidative stress is very important in the pathogenesis of AA. In this study, we believe that we clarified the pathogenesis of oxidative stress for AA patients by investigating the TAS, TOS, OSI levels, PON1, arylesterase and prolidase enzyme activity parameters.
<b><i>Background:</i></b> Psoriasis known as a chronic inflammatory skin disease is accompanied by metabolic disorders such as obesity, diabetes, and dyslipidemia. Vaspin (a serine protease inhibitor derived from visceral adipose tissue) is a newly identified adipokine and a link between inflammation and obesity has been reported. We aimed to determine whether vaspin gene polymorphism is associated with the development and/or clinical features of psoriasis vulgaris. <b><i>Methods:</i></b> Our study group consisted of 96 psoriasis vulgaris patients and 100 matched controls. Vaspin rs2236242 gene was genotyped using PCR. <b><i>Results:</i></b> The vaspin genotypes showed a meaningful difference between psoriasis and control groups (<i>p</i> = 0.02). The frequency of the vaspin rs2236242 TT genotype was lower in psoriasis patients than in control participants (<i>p</i> < 0.05). The TA genotype was associated with a 2.38-fold increased risk of psoriasis compared to the TT genotype (<i>p</i> = 0.007, odds ratio: 2.38; 95% confidence interval: 1.25–4.55), but not the AA genotype. All subjects were the Turkish population, the study in other populations is needed and the sample size was small in number. <b><i>Conclusion:</i></b> Our study demonstrated that vaspin rs2236242 polymorphism is related to psoriasis in the Turkish population. Polymorphisms of the vaspin gene might serve as diagnostic biomarkers of psoriasis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.