Serum pepsinogen II is a better diagnostic marker in gastric cancer

Cao, Xueyuan; Jia, Zhifang; Jin, Meishan; Cao, Donghui; Kong, Fei; Suo, Jian; Jiang, Jing

doi:10.3748/wjg.v18.i48.7357

Cited by 30 publications

(23 citation statements)

References 30 publications

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“…In a study with a middle-aged male cohort of Japanese and following-up for 10 years, the results showed that the sensitivity and specificity of serum PG were low for the diagnosis of gastric cancer (Iino et al, 2012). The study in Chinese also showed a similar conclusion (Cao et al, 2012). Actually, PG is a serum marker of chronic atrophic gastritis, not an ideal indicator for the screening and diagnosis of gastric cancer.…”

Section: Pepsinogens (Pg)supporting

confidence: 51%

Serum Protein and Genetic Tumor Markers of Gastric Carcinoma

He¹,

Zhang²

2013

Asian Pacific Journal of Cancer Prevention

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The high incidence of gastric cancer and consequent mortality pose severe threats to human health. Early screening, diagnosis and treatment are the key to improve the prognosis of the patients with gastric cancer. Gastroscopy with biopsy is an efficient method for the diagnosis of early gastric cancer, but the associated discomfort and high cost make it difficult to be a routine method for screening gastric cancer. Serum tumor marker assay is a simple and practical method for detection of gastric cancer, but it is limited by poor sensitivity and specificity. Therefore, people have been looking for novel serum markers of gastric cancer in recent years. Here we review the novel serum tumor markers of gastric cancer and their diagnostic significance, focusing on the discoveries from serum proteomics analyses and epigenetics researches.

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Section: Pepsinogens (Pg)supporting

confidence: 51%

Serum Protein and Genetic Tumor Markers of Gastric Carcinoma

He¹,

Zhang²

2013

Asian Pacific Journal of Cancer Prevention

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“…On the basis of physiological aspect, both PGI and PGII were important to reflect gastric mucosal status. Increasing serum PGII level is noted in the status of active inflammation [37][38][39][40]. Longstanding chronic active gastritis gastric mucosal glands are destroyed and turned to atrophic gastritis that initially lead serum PGI decline, by the time progression further PGII is gradually decreased [27,41].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area

Gantuya

Oyuntsetseg

Bolor³

et al. 2018

Gastric Cancer

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“…The quest for noninvasive methods to diagnose GC, the most feared complication of H. pylori infection, is one of the most active areas of research. Cao et al [15] deter-mined serum anti-H. pylori immunoglobulin G (IgG), pepsinogen I (PGI), and pepsinogen II (PGII) by ELISA in 450 patients with GC, 111 individuals with gastric atrophy, and 961 healthy controls. PGII levels were higher in patients with GC or gastric atrophy than in controls.…”

Section: Noninvasive Diagnosis Of Gastric Cancermentioning

confidence: 99%

Diagnosis and Epidemiology of Helicobacter pylori Infection

et al. 2013

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A limited amount of new information was published in the field of diagnosis and epidemiology of Helicobacter pylori this last year. Besides some improvement in current tests, it is interesting to note the attempts to identify severe disease, for example gastric cancer, by breath analysis using nanomaterialbased sensors. In contrast, the predictive value for gastric cancer and atrophy of pepsinogen determinations was found inadequate.Prevalence studies of H. pylori infection have been carried out in adults and children around the world in the general population but also in specific communities. The usual risk factors were found. In addition, a Japanese study highlighted the role of grandmothers in the familial transmission of H. pylori.A study showed that the infection may not always readily establish itself in children, given the number of transient infections observed. It was also noted that after eradication, a first-year relapse is likely to be a recurrence of the previous infection, while later on it is probably a reinfection with a new strain. Diagnosis General Evaluation of Helicobacter pylori Diagnostic TestsTwo studies evaluating different diagnostic methods in specific settings concluded that histology was the most accurate test: Choi et al.[1] evaluated several tests for detecting H. pylori in Korean patients with bleeding (n = 157) and nonbleeding (n = 247) peptic ulcer. In bleeding patients, the sensitivity and specificity were 92.5 and 96% for histology, 40 and 100% for culture, 85 and 92% for rapid urease test (RUT), and 97 and 56% for serology, respectively. The sensitivities of culture and RUT in bleeding patients were significantly lower than in nonbleeding patients. By contrast, histology was reliable regardless of bleeding. Tian et al. [2] reported a meta-analysis evaluating H. pylori diagnostic methods in patients with partial gastrectomy. The pooled sensitivity and specificity were 93 and 85% for histology, 77 and 89% for urea breath test (UBT), and 79 and 94% for RUT, respectively. They concluded that histology was the most reliable test in this setting. Invasive TestsEndoscopy A multicenter Japanese study evaluated the possibility to diagnose H. pylori by conventional endoscopy and chromoendoscopy using indigo carmine in comparison with histology performed according to the Sydney System, on 275 patients [3].Based on a set of indices including diffuse and spotted redness, enlarged and tortuous folds, and swelling, they achieved a sensitivity of 94% in the corpus and 88% in the antrum. However, the specificity was only 62 and 52%, respectively. Rapid urease testMoon et al. [4] studied 240 patients to compare the efficacy of RUT performed on separate gastric antrum and corpus tissue specimens versus on combined specimens, using histology as a gold standard. Combining tissues prior to RUT increased the detection of H. pylori from 137 (64%) in separate specimens to 148 (69.2%)

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Serum pepsinogen II is a better diagnostic marker in gastric cancer

Abstract: Serum PG II concentration and PGI/PG II ratio are potential biomarkers for H. pylori-infected gastric disease. PG II is independently associated with risk of gastric cancer.

Cited by 30 publications

References 30 publications

Serum Protein and Genetic Tumor Markers of Gastric Carcinoma

Serum Protein and Genetic Tumor Markers of Gastric Carcinoma

Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area

Diagnosis and Epidemiology of Helicobacter pylori Infection

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