Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area

Gantuya, Boldbaatar; Oyuntsetseg, Khasag; Bolor, Dashdorj; Erdene-Ochir, Yansan; Sanduijav, Ruvjir; Duger, Davaadorj; Tegshee, Tserentogtokh; Uchida, Tomohisa; Yamaoka, Yoshio

doi:10.1007/s10120-018-0844-8

Cited by 25 publications

(19 citation statements)

References 45 publications

(70 reference statements)

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“…For the GC precursor diseases, we previously reported that the extension of IM in the corpus was associated with an increased GC risk in Mongolian population . In our current study, H pylori was the predominant species in the gastritis and atrophy groups but was lower in IM group.…”

Section: Discussionsupporting

confidence: 50%

Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions

Gantuya

Serag

Matsumoto

et al. 2020

Aliment Pharmacol Ther

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Summary Background Incidence and mortality of gastric cancer (GC) are high in Mongolia despite Helicobacter pylori in the Mongolian population being less virulent. Aim To evaluate gastric bacterial microbiota profiles in patients with GC and its precursor histological conditions. Methods We conducted a case‐control study among 48 GC and 120 noncancer patients (20 normal gastric mucosa [control], 20 gastritis, 40 with atrophy and 40 intestinal metaplasia [IM]). We performed 16S rRNA gene amplicon sequencing and compared taxonomic and functional prediction profiles based on the diagnosis group and H pylori infection status. Results The highest overall bacterial alpha diversity metrics were observed in the control group, followed by the IM and cancer groups. The gastritis and atrophy groups had the least diversity. Lactobacilli and Enterococci were the dominant genus in several cancer patients especially in the absence of H pylori. In addition, Carnobacterium, Glutamicibacter, Paeniglutamicibacter, Fusobacterium and Parvimonas were associated with GC regardless of H pylori infection. Firmicutes were decreased in the gastritis and atrophy groups and increased in the IM and cancer groups. The functional metabolic activity of the Embden‐Meyerhof‐Parnas pathway and the utilization of sugar, were significantly increased in cancer group compared with the noncancer group. Conclusion Microbial factors other than H pylori may play a role in Mongolian GC. We identified novel associations between GC and the genera Enterococcus, Lactobacillus, Carnobacterium, Glutamicibacter, Paeniglutamicibacter, Fusobacterium, and Parvimonas.

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Section: Discussionsupporting

confidence: 50%

Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions

Gantuya

Serag

Matsumoto

et al. 2020

Aliment Pharmacol Ther

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“…At present, there are many methods for screening those at high-risk of gastric cancer, such as pepsinogen combined with H. pylori antibody testing for predicting and screening [33]. OLGA staging for gastritis can also predict the risk of gastric cancer [22], magnetic capsule endoscopy is used to diagnose superficial gastric mucosal lesions [34], and gene screening [35] and vaccine development [36] are all important research methods for improving the detection rate of LGIN.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination

Liu

Cai

Chen

et al. 2020

Gastroenterology Research and Practice

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Secondary prevention is an important strategy in gastric cancer. Low-grade intraepithelial neoplasia (LGIN) is the last stage of precancerous lesion, and its timely diagnosis can greatly improve the detection rate of early gastric cancer. We performed a prospective study to analyze the risk factors of gastric LGIN in asymptomatic subjects undergoing physical examination. A total of 3437 subjects were included in this study, and 2259 asymptomatic subjects were investigated from March 2015 to April 2018. Risk factors were evaluated, and the endoscopic features of LGIN and prognosis were described. The overall incidence of LGIN was 19.73% (678/3437), while the incidence of LGIN in the asymptomatic and symptomatic groups was 19.65% (444/2259) and 19.86% (234/1178), respectively (P = 0:884). The rate of Helicobacter pylori infection in this physical examination population was 39.13% (35.8% asymptomatic group, 45.5% symptomatic group; P ≤ 0:001). Risk factors including age, H. pylori infection, history of antibiotic misuse, and spicy and high-fat diet (all P < 0:05) were further verified by multivariate analysis as independent risk factors. History of antibiotic misuse and H. pylori infection showed significant associations with LGIN (odds ratio ðORÞ = 6:767, 95% confidence interval (CI) 3.873-11.825 and OR = 3:803, 95% CI 3.009-4.808, respectively). The most common endoscopic classification of LGIN was erosive gastritis (50.78%), and the major endoscopic appearance was Paris IIa (flat with slight elevation located mostly in the antrum). During the mean follow-up period of 15.02 months, 49.4% of LGIN regressed, 0.61% of LGIN progressed, and 50% of LGIN remained unchanged. History of antibiotic misuse and H. pylori infection were predominant risk factors of LGIN in asymptomatic subjects, and those individuals should consider early screening for gastric cancer.

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“…Gastric atrophy and IM are thought to be the precursor diseases for gastric cancer development [25]. According to our previous study, in addition to atrophy or IM, corpus predominant gastritis was associated with a higher risk for gastric cancer in the Mongolian population [26]. Therefore, the mechanisms contributing to the development of gastric cancer in Mongolia might differ from those in other countries with high incidence of gastric cancer where H. pylori , especially CagA types, play important roles.…”

Section: Discussionmentioning

confidence: 99%

Western-Type Helicobacter pylori CagA are the Most Frequent Type in Mongolian Patients

Tegshee

Gantuya

Subsomwong

et al. 2019

Cancers

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Helicobacter pylori infection possessing East-Asian-type CagA is associated with carcinogenesis. Mongolia has the highest mortality rate from gastric cancer. Therefore, we evaluated the CagA status in the Mongolian population. High risk and gastric cancer patients were determined using endoscopy and histological examination. H. pylori strains were isolated from different locations in Mongolia. The CagA subtypes (East-Asian-type or Western-type, based on sequencing of Glu-Pro-Ile-Tyr-Ala (EPIYA) segments) and vacA genotypes (s and m regions) were determined using PCR-based sequencing and PCR, respectively. In total, 368 patients were examined (341 gastritis, 10 peptic ulcer, and 17 gastric cancer). Sixty-two (16.8%) strains were cagA-negative and 306 (83.1%) were cagA-positive (293 Western-type, 12 East-Asian-type, and one hybrid type). All cagA-negative strains were isolated from gastritis patients. In the gastritis group, 78.6% (268/341) had Western-type CagA, 2.9% (10/341) had East-Asian-type, and 18.2% (61/341) were cagA-negative. However, all H. pylori from gastric cancer patients possessed Western-type CagA. Histological analyses showed that East-Asian-type CagA was the most virulent strains, followed by Western-type and cagA-negative strains. This finding agreed with the current consensus. CagA-positive strains were the most virulent type. However, the fact that different CagA types can explain the high incidence of gastric cancer might be inapplicable in Mongolia.

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Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area

Abstract: The serum diagnosis using PGI/II < 3.1 cut-off value is valuable marker to predict high risk patients for population based massive screening.

Cited by 25 publications

References 45 publications

Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions

Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions

Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination

Western-Type Helicobacter pylori CagA are the Most Frequent Type in Mongolian Patients

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