Serum Protein and Genetic Tumor Markers of Gastric Carcinoma

He, Chuanchao; Zhang, Kun‐He

doi:10.7314/apjcp.2013.14.6.3437

Cited by 13 publications

(7 citation statements)

References 41 publications

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“…Selective screening such following up patient with documented gastric intestinal atrophy and metaplasia may be more cost effective. Use of non-endoscopic screening as such using serum markers (gastrin and pepsinogen I/II ratio) (Shafaghi et al, 2013) or other novel markers can be further studied and considered (He et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Chong

Telisinghe²,

Abdullah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Gastric cancer is the second most common gastrointestinal cancer and is more common in the East, compared to the West. This study assesses the trend of gastric cancers in Brunei Darussalam, a developing nation with a predominantly Malay population. Materials and Methods: The cancer registry from 1986 to 2012 maintained by the Department of Pathology, the only State Laboratory at the RIPAS Hospital, Ministry of Health, was reviewed and data extracted for analyses. The age standardised rate (ASR) and age specific incidence rate were calculated based on the projected population. Cancers diagnosed below 45 years were categorised as young gastric cancer. Results: Over the study period, there were a total of 551 cases of gastric cancer diagnosed. The most common type was adenocarcinoma (87.9%), followed by lymphoma (6.1%) and gastrointestinal stromal tumour (2.8%). The overall mean age at diagnosis was 61.9 years old (range 15 to 98) with an increasing trend observed, but this was not significant (ANOVA). There were differences in the mean age at diagnosis for the different races (p=0.003 for trend), but not the gender (p=0.105). Young gastric cancer accounted for 14.9%, being more common in women, and in Expatriate and Malay populations compared to the Chinese. There was a decrease in the ASR, from 17.3/100,000 in 1986-1990 to 12.5/100,000 in 2006-2010. Chinese had a higher overall ASR (20.2/100,000) compared to the Malays (11.8/100,000). The age specific rates were comparable between men and women until the age group 55-59 years when the rates started to diverge, becoming higher in men. Chinese men had higher rates then Malay men whereas, the rates were higher or comparable between the women until the age group >70 when the rate for Chinese women overtook their Malay counterpart. Conclusions: Our study showed that there is a declining trend in the incidence of gastric cancer and higher rates were observed in men and Chinese.

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Section: Discussionmentioning

confidence: 99%

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Chong

Telisinghe²,

Abdullah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Gastric cancer itself is highly malignant and exhibits an inherited predisposition to infiltrate and metastasize. At present, the mechanisms underlying gastric cancer initiation, progression and metastasis are not fully understood (3). …”

Section: Introductionmentioning

confidence: 99%

Role of c-Src activity in the regulation of gastric cancer cell migration

et al. 2014

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Gastric cancer is associated with increased migration and invasion. In the present study, we explored the role of c-Src in gastric cancer cell migration and invasion. BGC-823 gastric cancer cells were used to investigate migration following treatment of these cells with the c-Src inhibitors, PP2 and SU6656. Migration and invasion were analyzed by wound healing and Transwell assays. Western blot analysis was used to detect the expression of MT1-MMP and VEGF-C, while the activity of MMP2 and MMP9 was monitored with gelatin zymography assay. Immunoprecipitation was used to detect interactions among furin, pro-MT1-MMP and pro-VEGF-C. MT1-MMP and VEGF-C expression levels were inhibited by PP2 and SU6656 treatment, in accordance with decreased c-Src activity. Similarly, the zymography assay demonstrated that the activity of MMP2 and MMP9 was decreased following PP2 or SU6656 treatment. Blockade of c-Src also inhibited the invasive and migratory capacity of BGC-823 cells. Notably, c-Src interacted with furin in vivo, while interactions between furin and its substrates, pro-MT1-MMP and pro-VEGF-C, were decreased by c-Src inhibitors. In conclusion, the interaction among furin and pro-MT1-MMP or pro-VEGF-C or other tumor-associated precursor enzymes can be regulated by c-Src activity, thus reducing or changing the expression of these enzymes in order to reduce the development of gastric cancer, invasion and metastasis.

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“…Ideally, good screening biomarkers should be associated with gastric cancer, regardless of H. pylori status ( 99 ), detectable in easily accessible body fluids, such as blood or urine, unrelated to the gender and age, and specific for detecting early stages of the disease ( 35 , 100 ). Although several epimarkers, such as CDH1 , CHFR , DAPK , GSTP1 , MLH1 , p15 , p16 , RUNX3 , RARβ , RASSF1A , and TFFPI2 have emerged as potential screening biomarkers that are detectable in serum or plasma of patients; none has yet reached a sufficiently high level of specificity and reliability for early detection of gastric cancer ( 89 , 96 ).…”

Section: Gastric Cancermentioning

confidence: 99%

Aberrant methylation patterns in cancer: a clinical view

Paska

Hudler

2015

Biochem Med

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Epigenetic mechanisms, such as DNA methylation, DNA hydroxymethylation, post-translational modifications (PTMs) of histone proteins affecting nucleosome remodelling, and regulation by small and large non-coding RNAs (ncRNAs) work in concert with cis and trans acting elements to drive appropriate gene expression. Advances in detection methods and development of dedicated platforms and methylation arrays resulted in an explosion of information on aberrantly methylated sequences linking deviations in epigenetic landscape with the initiation and progression of complex diseases. Here, we consider how DNA methylation changes in malignancies, such as breast, pancreatic, colorectal, and gastric cancer could be exploited for the purpose of developing specific diagnostic tools. DNA methylation changes can be applicable as biomarkers for detection of malignant disease in easily accessible tissues. Methylation signatures are already proving to be an important marker for determination of drug sensitivity. Even more, promoter methylation patterns of some genes, such as MGMT, SHOX2, and SEPT9, have already been translated into commercial clinical assays aiding in patient assessment as adjunct diagnostic tools. In conclusion, the changes in DNA methylation patterns in tumour cells are slowly gaining entrance into routine diagnostic tests as promising biomarkers and as potential therapeutic targets.

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Serum Protein and Genetic Tumor Markers of Gastric Carcinoma

Cited by 13 publications

References 41 publications

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Role of c-Src activity in the regulation of gastric cancer cell migration

Aberrant methylation patterns in cancer: a clinical view

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