Serum lipid and apolipoprotein concentrations in healthy men on diets enriched in either canola oil or safflower oil

Wardlaw, Gordon M.; Snook, Jean T.; Lin, Min-Chieh; Puangco, M. A.; Kwon, Jae-Sool

doi:10.1093/ajcn/54.1.104

Cited by 74 publications

(31 citation statements)

References 22 publications

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“…Effects on serum lipids, lipoproteins, and apolipoproteins are in line with earlier intervention studies with rapeseed oil (McDonald et al, 1989;Wardlaw et al, 1991;Valsta et al, 1992;Nydahl et al, 1994). Even with the relatively high fat content of the test diets, we found lower total and LDL cholesterol levels, apo B concentrations, and LDL=HDL ratios and no differences in HDL cholesterol levels after the RO diet compared to the SAT diet.…”

Section: Discussionsupporting

confidence: 85%

“…This development may lead to an increased dietary intake of MUFAs and PUFAs, especially a-linolenic acid (18:3 n-3). Several intervention studies with rapeseed oil-rich diets have shown favourable effects on the blood lipid profile in healthy volunteers (McDonald et al, 1989;Wardlaw et al, 1991;Valsta et al, 1992;Nydahl et al, 1994) and in hyperlipidemic patients (Lichtenstein et al, 1993;Gustafsson et al, 1994;Nydahl et al, 1995). In these studies, serum levels of total and low-density lipoprotein (LDL) cholesterol were reduced, while serum levels of triglycerides and highdensity lipoprotein (HDL) cholesterol remained unchanged.…”

Section: Introductionmentioning

confidence: 99%

“…However, epidemiological studies investigating effects of dietary monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) on the outcome of CHD are less conclusive (Caggiula & Mustad, 1997). Several intervention studies have demonstrated that the lipoprotein profile could be improved by substituting MUFA and PUFA for SAFA (McDonald et al, 1989;Wardlaw et al, 1991;Valsta et al, 1992;Nydahl et al, 1994). However, intervention studies with PUFA-rich diets have also shown that the susceptibility of lipoproteins to oxidation was increased and that very high intakes of PUFAs may carry nonfavourable effects on the development of atherosclerosis (Tsimikas & Reaven, 1998;Eritsland, 2000).…”

Section: Introductionmentioning

confidence: 99%

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A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids

Södergren¹,

Gustafsson²,

Basu³

et al. 2024

Eur J Clin Nutr

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Objective: To compare the effects of a rapeseed oil-based diet containing an increased proportion of easily oxidised polyunsaturated fatty acids such as a-linolenic acid with a diet rich in saturated fatty acids on the degree of lipid peroxidation in the human body. Design: A randomised cross-over study. Subjects and interventions: Nineteen healthy moderately hyperlipidemic subjects (six women and 13 men, age 50 AE 8 y and body mass index (BMI) 24.5 AE 2.6 kg=m 2 ) were given a rapeseed oil-based diet (RO) and a control diet (SAT) rich in saturated fatty acids during two consecutive 4 week periods separated by a 4 week wash-out period. Biomarkers of lipid peroxidation and antioxidants were analysed in plasma and urine. Results: No significant differences in plasma or urinary levels of free 8-iso-prostaglandin F 2a , plasma total 8-isoprostaglandin F 2a plasma hydroperoxides or plasma malondialdehyde were observed between the RO and SAT diets (P ¼ 0.14 -0.95). A higher concentration of serum g-tocopherol was detected after the RO diet compared to the SAT diet (P < 0.001), whereas the serum a-tocopherol concentration and plasma antioxidative capacity did not differ between the two test diets. The total cholesterol, LDL cholesterol and LDL=HDL ratio were lower after the RO diet compared to the SAT diet (P < 0.001), while HDL cholesterol and total triglyceride levels were similar after the two diets. Conclusion: These results suggest that a rapeseed oil-based diet rich in a-linolenic acid does not seem to increase the degree of lipid peroxidation in plasma and urine compared to a diet rich in saturated fats. This is possibly due to a sufficient content of antioxidants in the rapeseed oil diet to increase circulating concentrations of antioxidants that may protect unsaturated fatty acids from oxidation.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids

Södergren¹,

Gustafsson²,

Basu³

et al. 2024

Eur J Clin Nutr

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“…. , 27)ondiet</(<2=l 65) with the composition of that particular diet was modeled as follows: 33 Grundy et aP 4 Katan et al 35 McDonald et al 36 Mensink and Katan 10 Ginsberg et al 37 Mensink and Katan 38 Wardlaw and Snook 39 Berry et al 40 Chan et al 41 Wardlaw et al 42 VaJsta et al 43 Sat, saturated fatty acids; mono, monounsaturated fatty acids; poly, polyunsaturated fatty acids. ' x, Rotating-diet, crossover, or Latin square design; //, parallel design.…”

Section: Methodsmentioning

confidence: 99%

Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials.

Mensink¹,

Katan²

1992

Arterioscler Thromb

1,276

687

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To calculate the effect of changes in carbohydrate and fatty acid intake on serum lipid and lipoprotein levels, we reviewed 27 controlled trials published between 1970 and 1991 that met specific inclusion criteria. These studies yielded 65 data points, which were analyzed by multiple regression analysis using isocaloric exchanges of saturated (sat), monounsaturated (mono), and poly unsaturated (poly) fatty acids versus carbohydrates (carb) as the independent variables. For high density lipoprotein (HDL) we found the following equation: AHDL cholesterol (mmol/1) =0.012x(carb->sat) + 0.009x (carb-'mono) + 0.007 x(carb-»poly) or, in milligrams per deciliter, 0.47x(carb-»sat) + 034 x (carb-»mono) + 0.28x (carb-*poly). Expressions in parentheses denote the percentage of daily energy intake from carbohydrates that is replaced by saturated, cis-monounsaturated, or polyunsaturated fatty acids. All fatty acids elevated HDL cholesterol when substituted for carbohydrates, but the effect diminished with increasing unsaturation of the fatty acids. For low density lipoprotein (LDL) the equation was ALDL cholesterol (mmol/1) =0.033 x(carb-»sat) -0.006 x (carb->mono) -0.014 x (carb-»pory) or, In milligrams per deciliter, L28x(carb->sat) -0.24x(carb-»mono) -0.55x(carb-»poly). The coefficient for polyunsaturates was significantly different from zero, but that for monounsaturates was not For triglycerides the equation was Atriglycerides (mmol/1) = -0.025 x (carb-»sat) -0.022 x (carb-»-mono) -0.028 x (carb->poly) or, in milligrams per deciliter, -2.22x(carb-»sat) -1.99x(carb->mono) -2.47 x (carb-•poly). Thus, replacement of carbohydrates by fat lowered serum triglycerides independent of the nature of the fat Replacement of saturated by unsaturated fatty acids raised the HDL to LDL cholesterol ratio, whereas replacement by carbohydrates had no effect Thus, under isocaloric, metabolicward conditions the most favorable lipoprotein risk profile for coronary heart disease was achieved if saturated fatty acids were replaced by unsaturated fatty acids, with no decrease in total fat intake. Extrapolation of our data to free-living populations requires more insight into effects of diet on body weight; if high-oil diets promote obesity, then their favorable effects on serum lipids will be lost (Arteriosclerosis and Thrombosis 1992;12:911- gested that the cholesterol-decreasing effect of (n-6) polyunsaturated fatty acids is not limited to LDL but extends to HDL cholesterol. 7 -8 Second, recent studies have failed to show any effect of polyunsaturates on serum total and LDL cholesterol beyond that which could be accounted for by the displacement of saturates from the diet. 910For these reasons, we have screened the literature for well-controlled trials on the effect of dietary fatty acids on serum lipoproteins in humans. Results were combined to derive equations that relate changes in the dietary fatty acid intake to changes in serum HDL, LDL, and total cholesterol and trigh/ceride concentrations. We focused on the most common types of fatty a...

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“…Considering the economic aspect, in Brazil, safflower oil has a higher commercial value than soybean oil since the former is an imported product. Some studies have shown the beneficial effects of PUFA of safflower oil on energy metabolism and its contribution to reducing body fat (WARDLAW et al, 1991). However, these results can also be observed with the intake of other polyunsaturated oils such as soybean oil (RAMADAN et al, 2009; RUIZ-RODRIGUEZ; REGLERO; IBAÑEZ, 2010).…”

Section: Resultsmentioning

confidence: 99%

Encapsulated specialty oils commercialized in São Paulo state, Brazil: evaluation of identity (fatty acid profile) and compliance of fatty acids and Vitamin E contents with nutrition labeling

et al. 2013

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Encapsulated specialty oils commercialized in São Paulo state, Brazil, were evaluated for their identity (fatty acids profile) and compliance with nutrition labeling (fatty acids and Vitamin E (alpha tocopherol) contents). Twenty one samples [flaxseed oil (6), evening primrose (5), safflower (8), borage (1), and black currant (1)] purchased from local markets or collected by the health surveillance agency were analyzed. The fatty acids and vitamin E contents were analyzed by gas chromatography with flame ionization detector and liquid chromatography with UV detector, respectively. Nine samples were adulterated (5 samples of safflower oil, 3 of flaxseed oil, and one of evening primrose). Among them, 3 flaxseed and 2 safflower oil samples were probably adulterated by the addition of soybean oil. Conjugated linoleic acid (CLA) was found in two safflower oils samples although the sale of oils with conjugated linoleic acid (CLA) is not permitted by the National Health Surveillance Agency in Brazil (ANVISA). Only two samples presented all values in compliance with nutrition labeling (one safflower oil sample and one borage oil sample). The results show that a continuous monitoring of encapsulated specialty oils commercialized in Brazil is necessary including a greater number of samples and sanitary surveillance.

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Serum lipid and apolipoprotein concentrations in healthy men on diets enriched in either canola oil or safflower oil

Cited by 74 publications

References 22 publications

A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids

A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids

Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials.

Encapsulated specialty oils commercialized in São Paulo state, Brazil: evaluation of identity (fatty acid profile) and compliance of fatty acids and Vitamin E contents with nutrition labeling

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