Serum copper and ceruloplasmin concentrations in patients with primary breast cancer

Yenisey, Çiğdem; Fadiloğlu, Meral; Onvural, Banu

doi:10.1042/bst024321s

Cited by 8 publications

(8 citation statements)

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“…The concentrations of copper, cobalt, and tin are significantly elevated in the serum of breast cancer patients and vary with the stage of the disease, the highest concentrations being observed in advanced stages [107-113]. Serum levels of copper are also higher in premenopausal than in postmenopausal breast cancer patients.…”

Section: Environmental Exposure To Metals and Breast Cancermentioning

confidence: 99%

Metals and Breast Cancer

Byrne

Divekar

Storchan

et al. 2013

J Mammary Gland Biol Neoplasia

166

115

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Metalloestrogens are metals that activate the estrogen receptor in the absence of estradiol. The metalloestrogens fall into two subclasses: metal/metalloid anions and bivalent cationic metals. The metal/metalloid anions include compounds such as arsenite, nitrite, selenite, and vanadate while the bivalent cations include metals such as cadmium, calcium, cobalt, copper, nickel, chromium, lead, mercury, and tin. The best studied metalloestrogen is cadmium. It is a heavy metal and a prevalent environmental contaminant with no known physiological function. This review addresses our current understanding of the mechanism by which cadmium and the bivalent cationic metals activate estrogen receptor-α. The review also summarizes the in vitro and in vivo evidence that cadmium functions as an estrogen and the potential role of cadmium in breast cancer.

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Section: Environmental Exposure To Metals and Breast Cancermentioning

confidence: 99%

Metals and Breast Cancer

Byrne

Divekar

Storchan

et al. 2013

J Mammary Gland Biol Neoplasia

166

115

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“…Both hypercupraemia and increased levels of serum ceruloplasmin have been reported in human cancer patients (Yenisey et al . 1996; Vaidya and Kamalakar 1998).…”

Section: Hypercupraemiamentioning

confidence: 99%

Paraneoplastic manifestations of cancer in horses

Axiak

Johnson

2011

Equine Veterinary Education

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SummaryParaneoplastic manifestations of cancer, probably under-recognised in equine clinical practice, are often observed before the underlying primary disease is identified. This review provides a summary of paraneoplastic phenomena that have been reported in horses. The inclusion of paraneoplastic explanations in the differential diagnosis of common and challenging clinical problems should lead to earlier diagnosis and greater chance for successful therapeutic outcomes. In some cases, alterations in the clinical severity of paraneoplastic signs can be used as indicators of disease progression or response to treatment.

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“…We identified 12 toxicants that are released into the environment by industry (carbon tetrachloride, formaldehyde, methylene chloride, styrene, tetrachloroethylene, trichloroethylene, arsenic, cadmium, chromium, cobalt, copper, and nickel) for this study based on the criteria that they: (1) had been shown to be positively associated with breast cancer in epidemiological studies [25][26][27], (2) were TRI chemicals that met the OSHA carcinogen standard for any neoplasm [28] or were agents with estrogenic effects associated with breast cancer risk [29][30][31][32][33][34][35][36], (3) had release levels reported to TRI [20] using consistent release-reporting calculation methods during the study period, (4) had reported releases to TRI [20] for all years of the study period in Texas, and (5) had reported releases to TRI [20] for multiple counties in Texas during the study period.…”

Section: Environmental Toxicantsmentioning

confidence: 99%

“…Of the grouped chemicals (metals, metal oxides, and acid mists) in this study, only the metals; arsenic, cadmium, chromium, cobalt, lead, and nickel, met the OSHA carcinogen standard [28]. However, it is thought that copper may also be a breast carcinogen, since several past studies have shown that concentrations of copper along with cobalt have been shown to be significantly elevated in the serum of breast cancer patients, with higher levels observed in the advanced stages of breast cancer [30][31][32][33][34][35][36]. Furthermore, copper as well as cobalt, nickel, chromium, and lead have been shown to bind to the estrogen receptor-a with high affinity and to stimulate the proliferation of Mcf-7 breast cancer cells [29].…”

Section: Introductionmentioning

confidence: 99%

“…We began the selection process for these chemicals based on a recent literature review in which they were found to be positively associated with breast cancer in epidemiological studies [25][26][27], and were TRI chemicals that met the Occupational Safety and Health Administration (OSHA) carcinogen standard for any neoplasm [28] or were agents with estrogenic effects [29][30][31][32][33][34][35][36] associated with breast cancer risk. OSHA uses the most current National Toxicology Program [37] and International Agency for Cancer Research (IARC) [38] sources to compile a list of individual chemicals that are designated as known or suspect carcinogens.…”

Section: Introductionmentioning

confidence: 99%

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