An ecological study of the association of environmental chemicals on breast cancer incidence in Texas

Coyle, Yvonne M.; Hynan, Linda S.; Euhus, David M.; Minhajuddin, Abu

doi:10.1007/s10549-004-8268-z

Cited by 47 publications

(39 citation statements)

References 43 publications

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“…This result is consistent with previous findings from ecological 21) and cohort studies 22) , with particular regard to female workers in the electronics industry 13,14,23) . In particular, Sung et al showed an increased Standardized Incidence Ratio (SIR 1.38, 95% CI 1.11−1.70) among women first employed prior to 1974, which is when the Taiwan government promulgated a regulation on solvent use, and Peplonska et al found a significantly increased risk of breast cancer (OR 1.7, 95% CI 1.1−2.7) among electronic and electric equipment manufacturers.…”

Section: Discussionsupporting

confidence: 92%

Female Breast Cancer and Electrical Manufacturing: Results of a Nested Case‐control Study

Oddone

Edefonti²,

Scaburri

et al. 2014

Journal of Occupational Health

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Section: Discussionsupporting

confidence: 92%

Female Breast Cancer and Electrical Manufacturing: Results of a Nested Case‐control Study

Oddone

Edefonti²,

Scaburri

et al. 2014

Journal of Occupational Health

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“…An ecological study of the association between exposure to environmental chemicals and incidence of breast cancer in Texas showed a higher rate of breast cancer in counties in which Cr was released in the environment from industry, in comparison with other counties. In addition, the mean elemental contents of scalp hair of breast cancer patients showed higher levels of Cr compared to controls [49].…”

Section: Discussionmentioning

confidence: 90%

Occupational exposure to metals and risk of meningioma: a multinational case-control study

et al. 2016

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The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study.INTEROCC is a seven-country population-based case-control study including 1,906 adult meningioma cases and 5,565 population controls. Incident cases were recruited between 2000 and 2004. A detailed occupational history was completed and job titles were coded into standard international occupational classifications. Estimates of mean workday exposure to individual metals and to welding fumes were assigned based on a job-exposure-matrix. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression.Although more controls than cases were ever exposed to metals (14% vs. 11%, respectively), cases had higher median cumulative exposure levels. The ORs for ever vs. never exposure to any metal and to individual metals were mostly greater than 1.0, with the strongest association for exposure to iron (OR=1.26, 95%CI 1.0-1.58). In women, an increased OR of 1.70 (95%CI 1.0-2.89) was seen for ever vs never exposure to iron (OR in men 1.19 (95% CI 0.91-1.54), with positive trends in relation with both cumulative and duration of exposure. These results remained after consideration of other occupational metal or chemical co-exposures.In conclusion, an apparent positive association between occupational exposure to iron and meningioma risk was observed, particularly among women. Considering the fact that meningioma is a hormone dependent tumor, the hypothesis that an interaction between iron and estrogen metabolism may be a potential mechanism for a carcinogenic effect of iron should be further investigated.6

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“…The number of malignant mammary tumors increased in females treated with 100 mg/L formaldehyde or methyl alcohol alone. Some malignant mammary tumors were also found in treated males [Soffritti et al (2002)] Formaldehyde in the environment has been positively associated with breast cancer risk [Coyle et al (2005)]. Greater numbers of DNA-protein cross-links were found in the white cells of breast cancer patients than in matched controls [Wu et al (2002)].…”

Section: Relative Risk Data Linking Acetaldehyde/alcohol and Leukemiasmentioning

confidence: 99%

Preventing hereditary cancers caused by opportunistic carcinogens

Friedenson¹

2011

Nat Prec

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ObjectivesPrevious studies reported inherited BRCA1/2 deficits can cause cancer by impairing normal protective responses. Opportunistic carcinogens can exploit these deficits by causing chronic inflammation, constant cell death and replacement in a mutagenic environment, DNA crosslinking or double strand breaks. Some of the resulting cancers may be prevented if opportunistic carcinogens are identified. MethodsThe literature was systematically searched for carcinogens capable of exploiting deficits in BRCA1/2 pathways. Search criteria were common exposure, available information, required BRCA1/2 pathway repairs, increased risks for any cancer, and effects on stem cells. ResultsFormaldehyde and acetaldehyde are closely related carcinogens and common pollutants that seem everywhere. Alcohol metabolism also produces acetaldehyde. High levels of either carcinogen overwhelm normal detoxification systems, cause inflammation, inhibit DNA repair and produce DNA cross links as critical carcinogenic lesions. Searching model system studies revealed both carcinogens activate stem cells, BRCA1/2 pathways and connected BRCA1/2 pathways to myeloid leukemia. For example, the BRCA1-BARD1 complex is required for proper nucleophosmin functions. Nucleophosmin prevents a major subset of acute myeloid leukemia (AML). Next, these concepts were independently tested against risks for myeloid leukemia. Epidemiologic results showed that BRCA2 gene defects inherited on both chromosomes increased risks so dramatically that AML occurs in most children. Using data from 14 studies, known/potential heterozygous BRCA1/BRCA2 mutations increased risks for myeloid leukemias by at least 3 fold in 7 studies and by at least 50% in 12.Acetaldehyde occurs in breast milk. In model studies, excessive acetaldehyde/alcohol exposure affects estrogen metabolism and stimulates alternate alcohol detoxification pathways. These pathways can also cause DNA cross linking by releasing oxygen species and activating procarcinogens. Acetaldehyde in rats' drinking water increased incidence of leukemias, lymphomas, pancreatic tumors and fibroadenomas. Six human epidemiologic studies support an association between alcohol related genotype or alcohol consumption and early onset breast cancers, including those in BRCA1/2 mutation carriers. ConclusionsAlthough it is difficult to prove direct causation, BRCA1/2 mutation carriers may reduce cancer risks by avoiding excessive formaldehyde and acetaldehyde. Broader genetic testing and pharmacologic/nutritional detoxification are possible.

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An ecological study of the association of environmental chemicals on breast cancer incidence in Texas

Cited by 47 publications

References 43 publications

Female Breast Cancer and Electrical Manufacturing: Results of a Nested Case‐control Study

Female Breast Cancer and Electrical Manufacturing: Results of a Nested Case‐control Study

Occupational exposure to metals and risk of meningioma: a multinational case-control study

Preventing hereditary cancers caused by opportunistic carcinogens

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