Serum autoantibody profiles of <scp>I</scp>g<scp>A</scp>,<scp> I</scp>g<scp>E</scp> and <scp>I</scp>g<scp>M</scp> in canine pemphigus foliaceus

Bizikova, Petra; Olivry, Thierry; Mamo, Lisa B.; Dunston, Stanley M.

doi:10.1111/vde.12143

Cited by 11 publications

(16 citation statements)

References 17 publications

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“…Furthermore, it is important to note that an association between epidermal-specific auto-antibodies and complement proteins has been described previously in human pemphigus (Lessey et al, 2008;Qian et al, 2011); a cross-reaction among IgE, IgM, and IgG4 anti-DSG-1 response has been reported in human PF patients (Qian et al, 2011). In contrast, IgM autoreactivity was not detected when canine PF serum was used against either DSG-1 or DSC-1 (Bizikova et al, 2014), and canine PF showed dominant IgG auto-antibody reactivity (Pérez et al, 2002: Olivry et al, 2009). Moreover, a previous study also detected IgM-producing B-cells in the extracellular matrix of the dermis and in the intercellular epidermis in canine PF (Pérez et al, 2002).…”

Section: Discussionmentioning

confidence: 86%

Expression of keratins, epidermal proteins and inflammatory cells in superficial pemphigus dogs

Theerawatanasirikul¹,

Rungsipipat²,

Banlunara³

et al. 2018

BJVM

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SummaryTheerawatanasirikul, S., A. Rungsipipat, W. Banlunara & P. Pongket, 2018. Expression of keratins, epidermal proteins and inflammatory cells in superficial pemphigus dogs. Bulg. J. Vet. Med., 21, No 2,[186][187][188][189][190][191][192][193][194][195][196][197] Superficial pemphigus in dogs is an autoimmune skin disorder. The disease is characterised by the binding of auto-antibodies to desmosomal molecules including desmocollin-1, a major auto-antigen in dogs. However, data on the expression of epidermal proteins in dogs are still limited. Therefore, the aim of this study was to investigate the keratins and epidermal proteins in dogs with superficial pemphigus using immunohistochemistry. Skin biopsies were performed on dogs with pemphigus foliaceus (n=10), pan-epidermal pustular pemphigus (n=4) and pemphigus erythematosus (n=1). Immunostaining for keratin 5 and keratin 10 showed a premature and discontinuous pattern in the suprabasal layers of all pemphigus skin samples compared to the control group (P<0.05). Filaggrin, desmocollin-1 and claudin-1, but not involucrin, were significantly reduced (P<0.05). Inflammatory cells markedly infiltrated in the dermis and the lower epidermis of all pemphigus skins. This is the first report that associates changes in the expression of keratin 5, keratin 10, filaggrin and claudin-1 with reduced desmocollin-1 expression and subsequent loss of the epidermal barrier in superficial pemphigus.

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Section: Discussionmentioning

confidence: 86%

Expression of keratins, epidermal proteins and inflammatory cells in superficial pemphigus dogs

Theerawatanasirikul¹,

Rungsipipat²,

Banlunara³

et al. 2018

BJVM

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“…The clinical case described demonstrates the occurrence of pemphigus foliaceous due to pharmacodermic reaction after topical administration of Mupirocin. This disease is known as the most common auto-immune skin disease in dogs and involves the synthesis of antikeratinocyte autoantibodies [3,14,15].…”

Section: Discussionmentioning

confidence: 99%

“…PF is known as the most common autoimmune skin disease in dogs, involving naturally or induced autoantibodies production against desmoglein and desmocolin molecules [1,3]. Iatrogenic PF is subdivided in drug-induced, which drug discontinuance leads to disease regression, or drug-triggered, where the drug stimulates the disease natural development and progression [10,24].…”

Section: Introductionmentioning

confidence: 99%

“…With the appearance of such lesions, it was suspected that the patient was developing drug-triggered pemphigus foliaceous. The topical treatment of ocular lesions with 0.1% tacrolimus (Protopic ® ) 2 associated with systemic treatment with 1.2 mg kg -1 , SID, of prednisolone (Alcort ® ) 3 . The patient improved the dermatological clinical picture, however, some side effects have already become evident, such as the presence of telangiectasia, polyuria, polyphagia and polydipsia.…”

Section: Introductionmentioning

confidence: 99%

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Mupirocin Pemphigus-Like Drug Reaction in a Dog

Ferreira

Guedes

Bezerra

et al. 2019

Acta Scientiae. Vet.

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Background: Pharmacodermia is defined as adverse reaction in skin, mucosa and appendages, which generates morphofunctional alterations in cutaneous barrier, inducing autoimmune diseases, such as pemphigus foliaceous, which is known as the most common autoimmune skin disease in dogs. This disease involves autoantibodies against desmoglein and desmocolin molecules, being induced by the use of certain drugs. Mupirocin (pseudomonic acid A) is a broad-spectrum antibiotic with bacteriostatic activity, being effective against Gram-positive pathogens and used to control superficial bacterial folliculitis. Based on that, the aim of this study was to report a pemphigus-like lesions after topical use of mupirocin in dog. Case: An 1-year-old, uncastrated male, Poodle dog, weighing 13.8 kg was treated in a private clinic in Fortaleza. The main complaint was related to pruritus in abdominal and inguinal region, in addition of legs licking. Dermatological examination revealed melanic crusts, epidermal collars and diffuse pustules in inguinal, abdominal, perianal and thoraco-lumbar regions. The therapy was based on topical use of Mupirocin in form of 0.2% aquous spray. After drug administration, the animal presented urticaria, diffuse epidermal collars, papulo-crusted and pustular lesions, which were more evident in abdominal and inguinal region. Nasal erythema, binocular blepharitis, apathy and fever were also observed. Cytological examination and bacterial culture were performed, revealing inflammatory and acantholytic cells and no bacterial growth. Biopsy procedure revealed subcorneal pustule with presence of epithelial acantholytic cells and neutrophils, compatible with canine pemphigus foliaceous. The topical treatment of ocular lesions with 0.1% Tacrolimus associated with systemic treatment with high dose of prednisolone (1.2 mg kg -1 ). The patient improved the dermatological clinical signs, however, some side effects have already become evident, such as the presence of telangiectasia, polyuria, polyphagia and polydipsia. Heterodox therapy based on the use of azathioprine (2 mg kg -1 ) was chosen in order to reduce corticoid dose. After 3 days of therapy, blood material was collected for hepatic evaluation, detecting hepatotoxicity. From the results, azathioprine therapy was suspended, and only high-dose corticosteroid therapy (1.5 mg kg -1 ) was maintained. The patient presented a considerable improvement in the lesion after 10 days of treatment. Discussion: There have been reports that pharmacodermic reactions may be associated with the development of autoimmune diseases, such as pemphigus foliaceus and vulgaris. In some cases, the lesions regress after drug discontination. In others, the medication acts as a triggering factor, activating the genetic predisposition of patient, which develops the pathology even after therapy interruption. The drug related pemphigus-foliaceous is a well-recognized disease in humans, however this disease is limited to sporadic cases in dogs. The therapy was based in use of a high dose of p...

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“…Clinical signs normally consist of pustules that evolve rapidly into erosions covered with crusts . Histologically, PF is characterized by subcorneal acantholysis, due to IgG autoantibodies against the keratinocyte adhesion molecules; Desmoglein‐1 is a minor autoantigen in dogs with PF . A study reported that desmocollin‐1 represents a major canine PF autoantigen .…”

Section: Introductionmentioning

confidence: 99%