Serum Alpha-1-Antitriypsin Levels in Patients with Pseudoexfolative Syndrome

Cumurcu, Tongabay; Özyurt, Hüseyın; Demir, Helin Deniz; Yardım, Hüseyin

doi:10.1080/02713680701861752

Cited by 14 publications

(4 citation statements)

References 30 publications

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“… 13 By contrast, Sorkhabi et al has reported increased level of serum TNF-α to be risk a factor for systemic and ocular manifestations in patients with XFS (without glaucoma). 19 Similarly, there have been investigations where systemic inflammatory markers such as serum alpha 1-antitrypsin activity, 20 YKL-40, 21 high-sensitivity C-reactive protein 19 and neutrophil-to-lymphocyte ratio 22 have been associated with XFS/PEG.…”

Section: Discussionmentioning

confidence: 99%

Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma

Kondkar¹,

Azad²,

Almobarak³

et al. 2018

OPTH

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BackgroundTumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine, which plays a role in glaucomatous neurodegeneration. Based on the plausible role of inflammation in the pathogenesis of pseudoexfoliation glaucoma (PEG), we investigated whether there is any relationship between the levels of plasma TNF-α and PEG or any of its clinical indices in comparison to normal controls.MethodsThe study was designed as a retrospective analysis. Plasma samples from 49 PEG patients and 88 non-glaucomatous controls were evaluated for TNF-α levels using an enzyme-linked immunosorbent assay (ELISA). The assay was performed in duplicates on a biochemical/ELISA analyzer.ResultsThe two study groups were similar in age, sex and systemic disease distribution. The mean TNF-α concentration was significantly higher in the PEG patients (5.54±4.58 pg/mL) than in the control subjects (0.93±1.49 pg/mL; 95% confidence interval [CI] =3.50–5.72; p=0.000). The overall dose–response trend was significant (χ2=57.07, df=2; p=0.000). A moderate positive and significant correlation was seen between TNF-α level and cup/disc ratio, an important clinical index for PEG. Besides, binary logistic regression analysis showed that the risk of PEG was most significantly affected by TNF-α level as compared to no association with age and sex. In receiver operating characteristic analysis, the area under the curve was 0.777 (95% CI =0.682–0.872) and statistically significant (p=0.000).ConclusionElevated systemic levels of inflammatory marker, TNF-α, are associated with PEG and may possibly serve as a biomarker for undiagnosed early glaucoma and/or as a marker for disease progression.

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Section: Discussionmentioning

confidence: 99%

Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma

Kondkar¹,

Azad²,

Almobarak³

et al. 2018

OPTH

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“…21 Elevated levels of homocysteine in PEX patients with and without glaucoma may partly explain the increased risk of vascular disease among patients with PEX. 13,17,18 Cumurcu et al 22 reported that serum a-1 antitrypsin, an acute phase protein associated with inflammatory processes, is increased in patients with PEX. However, the results of our study showed no statistically significant difference in hsCRP levels between the XFS, XFG, and control participants.…”

Section: Discussionmentioning

confidence: 99%

Systemic High-sensitivity C-reactive Protein Level in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Yüksel

Pirhan

Altntaş

et al. 2010

Journal of Glaucoma

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“…Similarly, Turkyilmaz et al 24 have shown a relationship between PES and elevated serum levels of YKL-40 (chitinase-3-like protein 1), which has a role in endothelial dysfunction and inflammation. To date, elevated serum levels of several other molecules that have definitive roles in inflammatory processes (eg, cardiovascular and cerebrovascular disease, endothelial dysfunction), including high-sensitivity C-reactive protein, 25 tumor necrosis factora, 25 antiphospholipid antibody, 26 a 1-antitrypsin, 27 homocysteine, 28 and hydroxyproline 29 have been studied in the serum of patients with PES. In the present study, serum omentin levels were found to be lower in patients with PES compared with healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Omentin in Pseudoexfoliation Syndrome

Bucak

Tosun

Simavlı

et al. 2016

Journal of Glaucoma

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Serum Alpha-1-Antitriypsin Levels in Patients with Pseudoexfolative Syndrome

Abstract: Serum AAT levels were found to be increased in patients with PEX. Increased serum AAT levels in PEX may explain the role of inflammation in this group of patients.

Cited by 14 publications

References 30 publications

Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma

Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma

Systemic High-sensitivity C-reactive Protein Level in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Serum Levels of Omentin in Pseudoexfoliation Syndrome

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