Systemic High-sensitivity C-reactive Protein Level in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Abstract

Our findings indicated no difference in the hsCRP level between XFS, XFG, and controls. This study suggests that CRP is not a predictive marker of inflammation and peripheral endothelial dysfunction in XFS, which is accepted as a systemic disorder.

What is the Effect of Pseudoexfoliation Syndrome on Renal Function in Patients without Glaucoma?

“…29 In a study by Yuksel et al, serum creatinine levels of patients with PEX and control groups were reported to be similar. 30 In our study, no statistically significant difference was observed between biochemical data obtained from patients with PEX and the control group.…”

Elevated neutrophil-to-lymphocyte ratio in pseudoexfoliation syndrome

“…13 In contrast, high-sensitivity C-reactive protein had not been found as a predictive marker of inflammation and peripheral endothelial dysfunction in PEXS and PEXG. 14 The inflammation is an important component of other ocular diseases such as age-related macular degeneration (AMD) and vascular diseases of retina. [15][16][17] The relationship between NLR and diabetic retinopathy was shown.…”

Analysis of Genetically Determined Gene Expression Suggests Role of Inflammatory Processes in Exfoliation Syndrome

“…88,89 However, there are conflicting results for high sensitivity C-reactive protein. 90,91 In addition, the XFS gene sets are enriched for genes that map to variants implicated in coffee and caffeine intake. Effects of caffeine consumption in the etiology of XFS have been studied, on the premise that coffee consumption increases plasma homocysteine levels that are speculated to enhance XFS material formation by contributing to vascular damage, oxidative stress, and extracellular matrix alterations.…”