2018
DOI: 10.2147/opth.s155168
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Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma

Abstract: BackgroundTumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine, which plays a role in glaucomatous neurodegeneration. Based on the plausible role of inflammation in the pathogenesis of pseudoexfoliation glaucoma (PEG), we investigated whether there is any relationship between the levels of plasma TNF-α and PEG or any of its clinical indices in comparison to normal controls.MethodsThe study was designed as a retrospective analysis. Plasma samples from 49 PEG patients and 88 non-glaucomatous contro… Show more

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Cited by 31 publications
(25 citation statements)
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“… 15 In addition, based on a similar mechanism of an activated immune response, we recently demonstrated an association between plasma TNF-α and pseudoexfoliation glaucoma. 18 …”
Section: Discussionmentioning
confidence: 99%
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“… 15 In addition, based on a similar mechanism of an activated immune response, we recently demonstrated an association between plasma TNF-α and pseudoexfoliation glaucoma. 18 …”
Section: Discussionmentioning
confidence: 99%
“…However, the elevated level of TNF-α in the plasma (in this study) and the AH (previous studies) is a clear indication of an activated immune response triggered by inflammation and its plausible association with glaucomatous degeneration, 12 which is in accordance to our previous observation in pseudoexfoliation glaucoma. 18 …”
Section: Discussionmentioning
confidence: 99%
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“…PACG patients (n = 101) were diagnosed based on clinical evidence of anatomically closed angle showing the occurrence of appositional or synnechial closure of the anterior chamber angle (at least 270 o of the angle is occluded); raised IOP (≥21 mmHg); presence of optic disk damage with cup/disc ratio of at least 0.7 (in at least one eye); and loss of peripheral or advanced visual field [18]. PXG patients (n = 95) showed the presence of flaky exfoliation material along the pupil edges or anterior lens capsule, glaucomatous optic neuropathy and associated visual field loss, and high IOP in either or both the eyes as described previously [19]. Patients harboring secondary forms of glaucoma, history of optic neuropathies or visual impairment unrelated to glaucoma, steroid usage, ocular trauma, absence of sufficient fundus visualization for disk assessment, or refusal to enroll were excluded.…”
Section: Study Design and Populationmentioning
confidence: 62%